Maria de Arriba
NeuropsychologyPsychologySample preparationDementiaLipidome
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Publications 6
#1Katrina M. Moore (UCL: University College London)H-Index: 1
#2Jennifer M. Nicholas (Lond: University of London)H-Index: 20
Last. Daniel H. GeschwindH-Index: 129
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Summary Background Frontotemporal dementia is a heterogenous neurodegenerative disorder, with about a third of cases being genetic. Most of this genetic component is accounted for by mutations in GRN, MAPT, and C9orf72. In this study, we aimed to complement previous phenotypic studies by doing an international study of age at symptom onset, age at death, and disease duration in individuals with mutations in GRN, MAPT, and C9orf72. Methods In this international, retrospective cohort study, we col...
2 CitationsSource
#1Timothy Rittman (University of Cambridge)H-Index: 19
#2Robin J Borchert (University of Cambridge)H-Index: 4
Last. Miren ZulaicaH-Index: 2
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The presymptomatic phase of neurodegenerative diseases are characterized by structural brain changes without significant clinical features. We set out to investigate the contribution of functional network resilience to preserved cognition in presymptomatic genetic frontotemporal dementia. We studied 172 people from families carrying genetic abnormalities in C9orf72, MAPT, or PGRN. Networks were extracted from functional MRI data and assessed using graph theoretical analysis. We found that despit...
3 CitationsSource
#1Ane IriondoH-Index: 2
#2Mikel TaintaH-Index: 4
Last. Beatriz Abad-García (UPV/EHU: University of the Basque Country)H-Index: 11
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Abstract The cerebrospinal fluid (CSF) lipidome is attracting increasing attention due to the importance of lipids in brain molecular signaling and their involvement in several neurological diseases. Different solvent systems have been used for the extraction of multiple lipid classes from CSF but no comparative study of the effectiveness of these protocols has been carried out. To optimize CSF lipid extraction for lipidomic measurements by untargeted ultra-high performance liquid chromatography...
1 CitationsSource
#1Enrico Premi (University of Brescia)H-Index: 18
#2Vince D. Calhoun (UNM: University of New Mexico)H-Index: 93
Last. Miren ZulaicaH-Index: 2
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Abstract Frontotemporal Dementia (FTD) is preceded by a long period of subtle brain changes, occurring in the absence of overt cognitive symptoms, that need to be still fully characterized. Dynamic network analysis based on resting-state magnetic resonance imaging (rs-fMRI) is a potentially powerful tool for the study of preclinical FTD. In the present study, we employed a "chronnectome" approach (recurring, time-varying patterns of connectivity) to evaluate measures of dynamic connectivity in 4...
2 CitationsSource