Trishla Sinha
University Medical Center Groningen
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Publications 4
#1Arnau Vich Vila (UMCG: University Medical Center Groningen)H-Index: 13
#2Valerie Collij (UMCG: University Medical Center Groningen)H-Index: 6
Last. Rinse K. Weersma (UMCG: University Medical Center Groningen)H-Index: 52
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The human gut microbiota has now been associated with drug responses and efficacy, while chemical compounds present in these drugs can also impact the gut bacteria. However, drug–microbe interactions are still understudied in the clinical context, where polypharmacy and comorbidities co-occur. Here, we report relations between commonly used drugs and the gut microbiome. We performed metagenomics sequencing of faecal samples from a population cohort and two gastrointestinal disease cohorts. Diffe...
8 CitationsSource
#1Sanzhima Garmaeva (UMCG: University Medical Center Groningen)H-Index: 5
#2Trishla Sinha (UMCG: University Medical Center Groningen)H-Index: 3
Last. Alexandra Zhernakova (UMCG: University Medical Center Groningen)H-Index: 59
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The human gut harbors a complex ecosystem of microorganisms, including bacteria and viruses. With the rise of next-generation sequencing technologies, we have seen a quantum leap in the study of human-gut-inhabiting bacteria, yet the viruses that infect these bacteria, known as bacteriophages, remain underexplored. In this review, we focus on what is known about the role of bacteriophages in human health and the technical challenges involved in studying the gut virome, of which they are a major ...
9 CitationsSource
#1Trishla Sinha (UMCG: University Medical Center Groningen)H-Index: 3
#2Arnau Vich Vila (UMCG: University Medical Center Groningen)H-Index: 13
Last. Alexandra ZhernakovaH-Index: 59
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ABSTRACTSeveral gastrointestinal diseases show a sex imbalance, although the underlying (patho)physiological mechanisms behind this are not well understood. The gut microbiome may be involved in this process, forming a complex interaction with host immune system, sex hormones, medication and other environmental factors. Here we performed sex-specific analyses of fecal microbiota composition in 1135 individuals from a population-based cohort. The overall gut microbiome composition of females and ...
13 CitationsSource
#1Trishla SinhaH-Index: 3
#2S.A. ScherjonH-Index: 15
Last. Alexandra ZhernakovaH-Index: 59
view all 3 authors...
Our understanding of the gut microbiome has taken a huge leap in the past five years. We now know that the composition of the gut microbiome is extremely complex and that it is affected by a large number of host and environmental factors. [1] While studying the association of various factors with the gut microbiome, sex is a factor that is often corrected for. In this paper we throw light upon the studies focusing on how sex influences microbiome. We compare the female and male gut microbiome and ...