Ara Koh
University of Gothenburg
Publications 3
#1A. Molinaro (University of Gothenburg)H-Index: 5
#2Robert Caesar (University of Gothenburg)H-Index: 16
Last.Fredrik Bäckhed (UCPH: University of Copenhagen)H-Index: 75
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Abstract Objectives The nuclear receptor superfamily is a potential target for the development of new treatments for obesity and metabolic diseases. Increasing evidence has pointed towards the retinoic acid-related orphan receptor-alpha (RORα) as an important nuclear receptor involved in several biological processes. RORα full body knockout mice display improved metabolic phenotypes on both chow and high fat (60% fat, 20% carbohydrate) diets, but also have severe behavioral abnormalities. Here w...
#1Ara Koh (Sahlgrenska University Hospital)H-Index: 2
#2A. Molinaro (Sahlgrenska University Hospital)H-Index: 5
Last.Fredrik Bäckhed (UCPH: University of Copenhagen)H-Index: 75
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Summary Interactions between the gut microbiota, diet, and the host potentially contribute to the development of metabolic diseases. Here, we identify imidazole propionate as a microbially produced histidine-derived metabolite that is present at higher concentrations in subjects with versus without type 2 diabetes. We show that imidazole propionate is produced from histidine in a gut simulator at higher concentrations when using fecal microbiota from subjects with versus without type 2 diabetes ...
33 CitationsSource
#1Ara Koh (University of Gothenburg)H-Index: 2
#2Filipe De Vadder (University of Gothenburg)H-Index: 10
Last.Fredrik Bäckhed (UCPH: University of Copenhagen)H-Index: 75
view all 4 authors...
A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and what might be their mechanistic basis? A growing body of work implicates microbially produced metabolites as crucial executors of diet-based microbial influence on the host. Here, we will review data supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty aci...
595 CitationsSource