Match!
Yukiko Matsunaga
Princess Margaret Cancer Centre
Antigen processingImmunologyFOXP3BiologyCell biology
5Publications
1H-index
6Citations
What is this?
Publications 5
Newest
#1Yuki KagoyaH-Index: 12
#2Tingxi Guo (Princess Margaret Cancer Centre)H-Index: 7
Last. Yukiko Matsunaga (Princess Margaret Cancer Centre)H-Index: 1
view all 13 authors...
Adoptive immunotherapy can induce sustained therapeutic effects in some cancers. Antitumor T cell grafts are often individually prepared in vitro from autologous T cells, which requires an intensive workload and increased costs. The quality of the generated T cells can also be variable, which affects the therapy's antitumor efficacy and toxicity. Standardized production of antitumor T cell grafts from third-party donors will enable widespread use of this modality if allogeneic T cell responses a...
Source
#1Kenji Murata (Princess Margaret Cancer Centre)H-Index: 1
#2Munehide Nakatsugawa (Princess Margaret Cancer Centre)H-Index: 13
Last. Yuki Kagoya (Princess Margaret Cancer Centre)H-Index: 12
view all 25 authors...
HLA-restricted T cell responses can induce antitumor effects in cancer patients. Previous human T cell research has largely focused on the few HLA alleles prevalent in a subset of ethnic groups. Here, using a panel of newly developed peptide-exchangeable peptide/HLA multimers and artificial antigen-presenting cells for 25 different class I alleles and greater than 800 peptides, we systematically and comprehensively mapped shared antigenic epitopes recognized by tumor-infiltrating T lymphocytes (...
Source
#1Kenji Murata (Princess Margaret Cancer Centre)H-Index: 1
#2Munehide Nakatsugawa (Princess Margaret Cancer Centre)H-Index: 13
Last. Yuki Kagoya (Princess Margaret Cancer Centre)H-Index: 12
view all 25 authors...
Source
#1Mark Anczurowski (U of T: University of Toronto)H-Index: 6
#2Kenji Sugata (Princess Margaret Cancer Centre)H-Index: 1
Last. Naoto Hirano (U of T: University of Toronto)H-Index: 11
view all 12 authors...
Abstract Recent work has delineated key differences in the antigen processing and presentation mechanisms underlying HLA-DP alleles encoding glycine at position 84 of the DPβ chain (DP 84GGPM87 ). These DPs are unable to associate with the class II-associated Ii peptide (CLIP) region of the invariant chain (Ii) chaperone early in the endocytic pathway, leading to continuous presentation of endogenous antigens. However, little is known about the chaperone support involved in the loading of these ...
Source
#1Yuki Kagoya (Princess Margaret Cancer Centre)H-Index: 12
#2Hiroshi Saijo (Princess Margaret Cancer Centre)H-Index: 1
Last. Naoto Hirano (U of T: University of Toronto)H-Index: 11
view all 12 authors...
Abstract Forkhead box transcription factor 3 (FOXP3) plays a pivotal role in the suppressive function of regulatory T cells. In addition to mRNA levels, FOXP3 activity can also be controlled by posttranslational mechanisms, which have not been studied in a comprehensive manner. Through extensive screening using selective inhibitors, we demonstrate that the inhibition of type I protein arginine methytransferases (PRMTs) attenuates the suppressive functions of regulatory T cells. FOXP3 undergoes m...
6 CitationsSource
1