Hannah B. Mandle
Emory University
Publications 4
#1Veronika FedirkoH-Index: 40
Last.Mazda JenabH-Index: 66
view all 43 authors...
Higher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes related to vitamin D metabolism and action has not been well studied in humans. We investigated 1307 functional and tagging single-nucleotide polymorphisms (SNPs; individually, and by gene/pathway) in 86 vitamin D-related genes in 1420 incident CRC cases matched to controls f...
#2Mazda JenabH-Index: 66
Last.Veronika FedirkoH-Index: 40
view all 6 authors...
#1Hannah B. Mandle (Emory University)
#2Ferdous Akter Jahan (Emory University)
Last.Veronika Fedirko (Emory University)H-Index: 40
view all 10 authors...
#1Rebecca A Hodge (Emory University)
#2Hannah B. Mandle (Emory University)
Last.Veronika Fedirko (Emory University)H-Index: 40
view all 14 authors...
Chronic inflammation in the colorectum, a significant contributor to colorectal carcinogenesis, can be triggered by the activation of pro-inflammatory signaling pathways such as those initiated by Toll-like receptors (TLRs) and nuclear factor κB (NF-κB). Although experimental evidence supports calcium and vitamin D potentially modifying these pro-inflammatory pathways in the colorectum, human data in these regards are scarce. We investigated supplemental calcium (1,200 mg daily) and/or vitamin D...