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Chengyu Wang
Guangzhou Medical University
10Publications
2H-index
10Citations
Publications 10
Newest
#1Weijian Liu (Guangzhou Medical University)H-Index: 2
#2Yanling Zhou (Guangzhou Medical University)H-Index: 4
Last.Yuping Ning (Guangzhou Medical University)H-Index: 11
view all 0 authors...
Abstract Background Recent studies have suggested that neurocognition is changed after repeated infusions of ketamine in patients with treatment-resistant depression (TRD). The objective of this study was to investigate whether differences existed in the neurocognitive effect of six ketamine infusions in patients with anxious and nonanxious TRD and to determine the association between baseline neurocognition and changes in symptoms after the infusions. Method Patients with anxious (n = 30) and n...
#1Chengyu Wang (Guangzhou Medical University)H-Index: 2
#2Yanling Zhou (Guangzhou Medical University)H-Index: 4
Last.Ming D. Li (MPG: Max Planck Society)
view all 12 authors...
#1Yanni Zhan (Southern Medical University)
#2Bin Zhang (Guangzhou Medical University)
Last.Lin Yu (Guangzhou Medical University)
view all 13 authors...
Abstract Background Suicide is a tremendous public health crisis and is demanded urgent intervention. Previous studies found that ketamine intervention could rapidly reduce suicidal ideation in depression. However, the comparatively study in Chinese population remains absence. The current study aims to assess the anti-suicidal efficacy of repeated ketamine infusions for Chinese depressed suicidal patients, especially distinguish between low suicidal ideation (SI) group and high SI group. Methods...
#1Wei Zheng (Guangzhou Medical University)H-Index: 110
#2Wei Zheng (Guangzhou Medical University)H-Index: 11
Last.Ming D. Li (ZJU: Zhejiang University)
view all 9 authors...
Objective:Single-dose intravenous ketamine has rapid but time-limited antidepressant effects. We aimed to examine the sustained effects of six consecutive ketamine infusions in Chinese patients wit...
#1Weijian Liu (Southern Medical University)
#2Yanling Zhou (Guangzhou Medical University)H-Index: 4
Last.Yuping Ning (Southern Medical University)
view all 9 authors...
Abstract Background Major depressive disorder (MDD) is associated with neurocognitive impairment and reduced social-occupational function. However, neurocognition and social-occupational function in patients with anxious depression have been under-investigated. An increasing number of studies have demonstrated that neurocognition plays an important role in social-occupational function. The objective of this study was to investigate the association of severity of symptoms, neurocognition and soci...
#1Wei Zheng (Guangzhou Medical University)H-Index: 110
#2Wei Zheng (Guangzhou Medical University)H-Index: 11
Last.Yuping Ning (Guangzhou Medical University)H-Index: 11
view all 9 authors...
Abstract Objective Ketamine has demonstrated a rapid antidepressant and antisuicidal effect in patients with major depressive disorder (MDD), but the neurocognitive effects of ketamine are relatively unknown. This study aims to examine the neurocognitive effects of six ketamine infusions and the association of baseline neurocognitive function and the change in severity of depressive symptoms after the last infusions. Methods Sixty-four patients with MDD completed six intravenous infusions of ket...
#1Yanling Zhou (Guangzhou Medical University)H-Index: 4
#2Wei Zheng (Guangzhou Medical University)H-Index: 110
Last.Yuping Ning (Guangzhou Medical University)H-Index: 11
view all 8 authors...
Abstract Objective Cognitive impairment is common among patients with major depressive disorder (MDD), but its pathological mechanism is complex and not fully understood. Evidence suggests that the kynurenine (KYN) pathway may be implicated in the pathophysiology of depression, but few studies have explored the association between the KYN pathway and cognitive impairment in MDD. Our aim was to examine the relationship between cognitive impairment and KYN pathway metabolites in patients with MDD....
#1Yanling Zhou (Guangzhou Medical University)H-Index: 4
#2Yanling Zhou (Guangzhou Medical University)H-Index: 1
Last.Mingding Li (ZJU: Zhejiang University)H-Index: 2
view all 9 authors...
Abstract Ketamine has rapid antidepressant effects on treatment-resistant depression, but the biological mechanism underpinning this effect is less clear. Our aims were to examine whether kynurenine pathway metabolites were altered by six infusions of ketamine and whether these biological factors could act as potential biomarkers to predict ketamine’s antidepressant effects. Six intravenous infusions of ketamine (0.5 mg/kg) were administered to 84 patients with unipolar and bipolar depression ov...
#1Wei Zheng (Guangzhou Medical University)H-Index: 11
#2Yanling Zhou (Guangzhou Medical University)H-Index: 2
Last.Yuping Ning (Guangzhou Medical University)H-Index: 11
view all 9 authors...
Abstract Objective Single-dose intravenous (IV) injection of ketamine has shown rapid but transient antidepressant effects. The strategy of repeated-dose ketamine infusions to maintain antidepressant effects has received little systematic study. This study was conducted to examine the efficacy and tolerability of six ketamine infusions in Chinese patients with unipolar and bipolar depression. Methods Ninety seven patients with unipolar (n = 77) and bipolar (n = 20) depression received repeated k...
#1Yanling Zhou (Guangzhou Medical University)H-Index: 4
#2Yanling Zhou (Guangzhou Medical University)H-Index: 2
Last.Mingding Li (ZJU: Zhejiang University)H-Index: 2
view all 9 authors...
Background:Ketamine has proven to have rapid, robust antidepressant effects on treatment-resistant depression. However, whether repeated ketamine infusions would cause short-and long-term neurocognitive impairments was not clear. Our aims were to investigate the neurocognitive effects of six ketamine infusions and to examine the association between these infusions and the antidepressant response in patients with unipolar and bipolar depression.Methods:Six intravenous infusions of ketamine (0.5 m...
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