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Ran Li
Zhejiang Chinese Medical University
OffspringFetusPregnancyMorris water navigation taskGestation
2Publications
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Publications 3
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#1Bo Wang (Anhui Medical University)H-Index: 10
#1Bo WangH-Index: 2
Last. Guo-Ping SunH-Index: 1
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Abstract 1-nitropyrene (1-NP) is a key component of diesel exhaust-sourced fine particulate matter (PM2.5). Our recent study demonstrated that gestational 1-NP exposure caused placental proliferation inhibition and fetal intrauterine growth restriction (IUGR). This study aimed to investigate the role of genotoxic stress on 1-NP-induced placental proliferation inhibition and fetal IUGR. Human trophoblasts were exposed to 1-NP (10 μM). Growth index was reduced and PCNA was downregulated in 1-NP-ex...
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#1Ran Li (ZJNU: Zhejiang Chinese Medical University)H-Index: 1
#2Xilu Wang (Anhui Medical University)H-Index: 1
Last. De-Xiang Xu (Anhui Medical University)H-Index: 32
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Abstract 1-Nitropyrene (1-NP), a typical nitrated polycyclic aromatic hydrocarbon, is widely distributed in the environment and is well known for its mutagenic effects. Recently, we found that gestational 1-NP exposure induced fetal growth restriction. In this study, we further evaluated the effect of in utero 1-NP exposure on postnatal growth and neurobehavioral development in the offspring. Pregnant mice were administered with 1-NP (10 μg/kg) by gavage daily in late pregnancy (GD13-GD17). The ...
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#1Ran Li (ZJNU: Zhejiang Chinese Medical University)H-Index: 1
#2Xilu Wang (Anhui Medical University)H-Index: 1
Last. De-Xiang Xu (Anhui Medical University)H-Index: 32
view all 10 authors...
Abstract 1-Nitropyrene (1-NP) is a widely distributed pollutant in the environment and is best known for its mutagenicity and carcinogenicity. In this study, we evaluated the effects of 1-NP exposure in different gestational stages on the pregnant outcomes. Pregnant mice were administered with 1-NP by gavage daily in early (GD1-GD6), middle (GD7-GD12) or late pregnancy (GD13-GD17), respectively. We found that gestational 1-NP exposure had no effect on implantation sites per litter, preterm deliv...
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