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Lowell T. Nicholson
University of California, San Francisco
Chemokine receptorCXCR3T cellImmunotherapyMedicine
7Publications
2H-index
13Citations
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Publications 7
Newest
#1L.T. Nicholson (UCSF: University of California, San Francisco)
#1Lowell T. Nicholson (UCSF: University of California, San Francisco)H-Index: 2
Last. Anna Haemel (UCSF: University of California, San Francisco)H-Index: 13
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#1Lowell Thorndike Nicholson (UCSF: University of California, San Francisco)
#1Lowell T. Nicholson (UCSF: University of California, San Francisco)H-Index: 2
Last. Lawrence Fong (UCSF: University of California, San Francisco)H-Index: 44
view all 2 authors...
Although immunotherapy has proved to be effective in a variety of cancer subtypes, the role of immune checkpoint inhibition in the treatment of prostate cancer remains unclear. Here we review results from the latest clinical trials and discuss data suggesting that certain genetic mutations may confer increased sensitivity to immune checkpoint blockade.
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Efficacy of dendritic cell (DC) cancer vaccines is classically thought to depend on their antigen-presenting cell (APC) activity. Studies show, however, that DC vaccine priming of cytotoxic T lymphocytes (CTLs) requires the activity of endogenous DCs, suggesting that exogenous DCs stimulate antitumor immunity by transferring antigens (Ags) to endogenous DCs. Such Ag transfer functions are most commonly ascribed to monocytes, implying that undifferentiated monocytes would function equally well as...
6 CitationsSource
Last. Sudarshan RajagopalH-Index: 26
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#1Jeffrey S. Smith (Duke University)H-Index: 11
#2Lowell T. Nicholson (Duke University)H-Index: 2
Last. Sudarshan Rajagopal (Duke University)H-Index: 26
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The chemokine receptor CXCR3 plays a central role in inflammation by mediating effector/memory T cell migration in various diseases; however, drugs targeting CXCR3 and other chemokine receptors are largely ineffective in treating inflammation. Chemokines, the endogenous peptide ligands of chemokine receptors, can exhibit so-called biased agonism by selectively activating either G protein– or β-arrestin–mediated signaling after receptor binding. Biased agonists might be used as more targeted ther...
5 CitationsSource
PurposeLow- and middle-income countries disproportionately comprise 65% of cancer deaths. Cancer care delivery in resource-limited settings, especially low-income countries in sub-Saharan Africa, is exceedingly complex, requiring multiple modalities of diagnosis and treatment. Given the vast human, technical, and financial resources required, access to radiotherapy remains limited in sub-Saharan Africa. Through 2017, Rwanda has not had in-country radiotherapy services. The aim of this study was ...
2 CitationsSource
#1Krish Patel (Duke University)H-Index: 3
#2Lowell T. Nicholson (Duke University)H-Index: 2
Last. Richard F. Riedel (Duke University)H-Index: 29
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e18023Background: Medical oncology patients have high rates of unplanned hospital admissions. The characteristics of these admissions and the medical needs of this patient population have not been ...
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