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James A. Hay
Imperial College London
3Publications
1H-index
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#1James A. Hay (Imperial College London)H-Index: 1
#2Karen L. LaurieH-Index: 26
Last.Steven Riley (Imperial College London)H-Index: 41
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The strength and breadth of an individual’s antibody repertoire is an important predictor of their response to influenza infection or vaccination. Although progress has been made in understanding qualitatively how repeated exposures shape the antibody mediated immune response, quantitative understanding remains limited. We developed a set of mathematical models describing short-term antibody kinetics following influenza infection or vaccination and fit them to haemagglutination inhibition (HI) t...
#1James A. Hay (Imperial College London)H-Index: 1
#2Amanda Minter (Lond: University of London)H-Index: 4
Last.Steven Riley (Imperial College London)H-Index: 41
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Abstract We present a flexible, open source R package designed to obtain additional biological and epidemiological insights from commonly available serological datasets. Analysis of serological responses against pathogens with multiple strains such as influenza pose a specific statistical challenge because observed antibody responses measured in serological assays depend both on unobserved prior infections and the resulting cross-reactive antibody dynamics that these infections generate. We prov...
#1James A. Hay (Imperial College London)H-Index: 1
#2Pierre Nouvellet (Imperial College London)H-Index: 21
Last.Steven Riley (Imperial College London)H-Index: 41
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Background A significant increase in microcephaly incidence was reported in Northeast Brazil at the end of 2015, which has since been attributed to an epidemic of Zika virus (ZIKV) infections earlier that year. Further incidence of congenital Zika syndrome (CZS) was expected following waves of ZIKV infection throughout Latin America; however, only modest increases in microcephaly and CZS incidence have since been observed. The quantitative relationship between ZIKV infection, gestational age and...
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