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Jie Yu
Zhejiang Chinese Medical University
8Publications
2H-index
9Citations
Publications 10
Newest
#2Song Cai (UA: University of Arizona)H-Index: 6
Last.Jie YuH-Index: 2
view all 10 authors...
Antiepileptic drugs (AEDs) are the primary agents prescribed for clinical management of limbic epilepsy. However, high incidence of pharmacoresistance and a limited armory of drugs for inhibiting the pathological progression of epilepsy pose major obstacles to managing epilepsy. Here, we investigated the effect of Tetramethylpyrazine (TMP), the main bioactive alkaloid isolated from the oriental medicine Ligusticum chuanxiong Hort., against the epileptogenesis progression of acute hippocampal and...
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#1Yuan Zhou (UA: University of Arizona)H-Index: 1
#2Song Cai (UA: University of Arizona)H-Index: 6
Last.Rajesh Khanna (UA: University of Arizona)H-Index: 31
view all 16 authors...
Naringenin (2S)‐5,7‐dihydroxy‐2‐(4‐hydroxyphenyl)‐3,4‐dihydro‐2H‐1‐benzopyran‐4‐one is a natural flavonoid found in fruits from the citrus family. Since (2S)-Naringenin is known to racemize, its bioactivity might be related to one or both enantiomers. Computational studies predicted that (2R)-Naringenin may act on voltage-gated ion channels, particularly the N-type calcium channel (CaV2.2) and the NaV1.7 sodium channel – both key for pain signaling. Here we set out to identify the possible mecha...
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#1Udaiyappan Janakiraman (UA: University of Arizona)H-Index: 1
#2Jie Yu (ZJNU: Zhejiang Chinese Medical University)H-Index: 2
Last.Mark A. Nelson (UA: University of Arizona)H-Index: 32
view all 9 authors...
Abstract TAF1/MRSX33 intellectual disability syndrome is an X-linked disorder caused by loss-of-function mutations in the TAF1 gene. How these mutations cause dysmorphology, hypotonia, intellectual and motor defects is unknown. Mouse models which have embryonically targeted TAF1 have failed, possibly due to TAF1 being essential for viability, preferentially expressed in early brain development, and intolerant of mutation. Novel animal models are valuable tools for understanding neuronal patholog...
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#1Jie Yu (ZJNU: Zhejiang Chinese Medical University)H-Index: 2
#2Aubin Moutal (UA: University of Arizona)H-Index: 13
Last.Rajesh Khanna (UA: University of Arizona)H-Index: 31
view all 10 authors...
The collapsin response mediator protein 2 (CRMP2) has emerged as a central node in assembling nociceptive signaling complexes involving voltage-gated ion channels. Concerted actions of post-translational modifications, phosphorylation and SUMOylation, of CRMP2 contribute to regulation of pathological pain states. In the present study, we demonstrate a novel role for CRMP2 in spinal nociceptive transmission. We found that, of six possible post-translational modifications, three phosphorylation si...
3 CitationsSource
#1Rajesh KhannaH-Index: 31
#2Jie YuH-Index: 2
Last.May KhannaH-Index: 19
view all 19 authors...
AbstractInhibition of voltage-gated calcium (CaV) channels is a potential therapy for many neurological diseases including chronic pain. Neuronal CaV1/CaV2 channels are composed of α, β, γ and α2δ subunits. The β subunits of CaV channels are cytoplasmic proteins that increase the surface expression
4 CitationsSource
#1Zhiming Shan (SYSU: Sun Yat-sen University)
#2Song Cai (UA: University of Arizona)H-Index: 6
Last.Rajesh Khanna (UA: University of Arizona)H-Index: 31
view all 18 authors...
No universally efficacious therapy exists for chronic pain, a disease affecting one-fifth of the global population. An overreliance on the prescription of opioids for chronic pain despite their poor ability to improve function has led to a national opioid crisis. In 2018, the NIH launched a Helping to End Addiction Long-term plan to spur discovery and validation of novel targets and mechanisms to develop alternative nonaddictive treatment options. Phytochemicals with medicinal properties have lo...
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#1Song Cai (UA: University of Arizona)H-Index: 6
#2Shreya S. Bellampalli (UA: University of Arizona)H-Index: 3
Last.Rajesh Khanna (UA: University of Arizona)H-Index: 31
view all 14 authors...
For an affliction that debilitates an estimated 50 million adults in the United States, the current chronic pain management approaches are inadequate. The Centers for Disease Control and Prevention have called for a minimization in opioid prescription and use for chronic pain conditions, and thus, it is imperative to discover alternative non-opioid based strategies. For the realization of this call, a library of natural products was screened in search of pharmacological inhibitors of both voltag...
1 CitationsSource
#1Janakiraman Udaiyappan (UA: University of Arizona)
#2Jie Yu (UA: University of Arizona)H-Index: 2
Last.Mark A. Nelson (UA: University of Arizona)H-Index: 32
view all 7 authors...
TAF1 intellectual disability syndrome is an X-linked disorder caused by loss-of-function mutations in the TAF1 gene. How these mutations cause dysmorphology, hypotonia, intellectual and motor defects is unknown. Mouse models which have embryonically targeted TAF1 have failed, possibly due to TAF1 being essential for viability, preferentially expressed in early brain development, and intolerant of mutation. Novel animal models are valuable tools for understanding neuronal pathology. Here, we repo...
Source
#1Shreya S. Bellampalli (UA: University of Arizona)H-Index: 3
#2Yingshi Ji (UA: University of Arizona)H-Index: 3
Last.Rajesh KhannaH-Index: 31
view all 18 authors...
3 CitationsSource
#1Aude Chefdeville (UA: University of Arizona)H-Index: 3
#2Jie Yu (UA: University of Arizona)H-Index: 2
Last.Rajesh KhannaH-Index: 31
view all 18 authors...
Inhibition of voltage-gated calcium (CaV) channels is a potential therapy for many neurological diseases including chronic pain. Neuronal CaV1/CaV2 channels are composed of α, β and α2δ subunits. The β-subunits of CaV channels are cytoplasmic proteins that increase the surface expression of the pore-forming α subunit of CaV. We targeted the high-affinity protein-protein interface of CaVβ pocket within the CaVα-subunit. Structure-based virtual screening of 50,000 small molecule library docked...
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