Match!
Jie Yu
Zhejiang Chinese Medical University
7Publications
1H-index
4Citations
Publications 7
Newest
#1Udaiyappan Janakiraman (UA: University of Arizona)
#2Jie Yu (ZJNU: Zhejiang Chinese Medical University)H-Index: 1
Last.Mark A. Nelson (UA: University of Arizona)H-Index: 32
view all 9 authors...
Abstract TAF1/MRSX33 intellectual disability syndrome is an X-linked disorder caused by loss-of-function mutations in the TAF1 gene. How these mutations cause dysmorphology, hypotonia, intellectual and motor defects is unknown. Mouse models which have embryonically targeted TAF1 have failed, possibly due to TAF1 being essential for viability, preferentially expressed in early brain development, and intolerant of mutation. Novel animal models are valuable tools for understanding neuronal patholog...
#1Jie Yu (ZJNU: Zhejiang Chinese Medical University)H-Index: 1
#2Aubin Moutal (UA: University of Arizona)H-Index: 11
Last.Rajesh Khanna (UA: University of Arizona)H-Index: 30
view all 10 authors...
The collapsin response mediator protein 2 (CRMP2) has emerged as a central node in assembling nociceptive signaling complexes involving voltage-gated ion channels. Concerted actions of post-translational modifications, phosphorylation and SUMOylation, of CRMP2 contribute to regulation of pathological pain states. In the present study, we demonstrate a novel role for CRMP2 in spinal nociceptive transmission. We found that, of six possible post-translational modifications, three phosphorylation si...
#1Zhiming Shan (SYSU: Sun Yat-sen University)
#2Song CaiH-Index: 5
Last.Aubin MoutalH-Index: 11
view all 18 authors...
No universally efficacious therapy exists for chronic pain, a disease affecting one-fifth of the global population. An overreliance on the prescription of opioids for chronic pain despite their poor ability to improve function has led to a national opioid crisis. In 2018, the NIH launched a Helping to End Addiction Long-term plan to spur discovery and validation of novel targets and mechanisms to develop alternative nonaddictive treatment options. Phytochemicals with medicinal properties have lo...
#1Song CaiH-Index: 5
Last.May Khanna (UA: University of Arizona)H-Index: 10
view all 14 authors...
For an affliction that debilitates an estimated 50 million adults in the United States, the current chronic pain management approaches are inadequate. The Centers for Disease Control and Prevention have called for a minimization in opioid prescription and use for chronic pain conditions, and thus, it is imperative to discover alternative non-opioid based strategies. For the realization of this call, a library of natural products was screened in search of pharmacological inhibitors of both voltag...
#1Janakiraman Udaiyappan (UA: University of Arizona)
#2Jie Yu (UA: University of Arizona)H-Index: 1
Last.Mark A. Nelson (UA: University of Arizona)H-Index: 32
view all 7 authors...
TAF1 intellectual disability syndrome is an X-linked disorder caused by loss-of-function mutations in the TAF1 gene. How these mutations cause dysmorphology, hypotonia, intellectual and motor defects is unknown. Mouse models which have embryonically targeted TAF1 have failed, possibly due to TAF1 being essential for viability, preferentially expressed in early brain development, and intolerant of mutation. Novel animal models are valuable tools for understanding neuronal pathology. Here, we repo...
#1Aude Chefdeville (UA: University of Arizona)H-Index: 1
#2Jie Yu (UA: University of Arizona)H-Index: 1
Last.Liberty François-Moutal (UA: University of Arizona)H-Index: 8
view all 18 authors...
Inhibition of voltage-gated calcium (CaV) channels is a potential therapy for many neurological diseases including chronic pain. Neuronal CaV1/CaV2 channels are composed of α, β and α2δ subunits. The β-subunits of CaV channels are cytoplasmic proteins that increase the surface expression of the pore-forming α subunit of CaV. We targeted the high-affinity protein-protein interface of CaVβ pocket within the CaVα-subunit. Structure-based virtual screening of 50,000 small molecule library docked...
1