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Athina Chasapi
University of Patras
Adipose tissueInflammationCancer researchMedicineBiomarker (medicine)
3Publications
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Publications 5
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#1Athina Chasapi (University of Patras)
#2Kostas Balampanis (University of Patras)
Last. Georgia Sotiropoulou-Bonikou (University of Patras)H-Index: 15
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BACKGROUND: Estrogen receptor beta (ERbeta) plays an important role in human metabolism and some of its metabolic actions are mediated by a positive "cross-talk" with Nuclear Factor of Activated T cells (NFAT) and the key metabolic transcriptional coregulator Transcriptional Intermediary Factor 2 (TIF2). INTRODUCTION: Our study is an "in situ" morphological evaluation of the communication between ERbeta, NFAT and TIF2 in morbid obesity. Potential correlations with clinicopathological parameters ...
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#1Athina Chasapi (University of Patras)
#2Konstantinos Balampanis (University of Patras)
Last. Georgia Sotiropoulou-Bonikou (University of Patras)H-Index: 15
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BACKGROUND: Obesity is a global epidemic which is associated with several cardiometabolic comorbidities and is characterized by chronic, low grade systemic inflammation. Numerous biomarkers have been implicated in the pathophysiology of the disease, including transcription factors and coregulators. Steroid Receptor Coactivator (SRC)-family represent the master regulators of metabolic pathways and their dysregulation is strongly associated with numerous metabolic disorders. METHODS: 50 morbidly o...
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#1Konstantinos Balampanis (University of Patras)
#2Athina Chasapi (University of Patras)
Last. Georgia Sotiropoulou-Bonikou (University of Patras)H-Index: 15
view all 11 authors...
Abstract Objective PGC-1α is already known as a significant regulator of mitochondrial biogenesis, oxidative phosphorylation and fatty acid metabolism. Our study focuses on the role of PGC1α in morbid obesity, in five different tissues, collected from 50 severely obese patients during planned bariatric surgery. Methods The investigated tissues included subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), skeletal muscle (SM), extramyocellular adipose tissue (EMAT) and liver. PGC1α e...
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Objectives: Obesity is characterized by a chronic, low grade, systemic inflammation. However, little is known about the role of skeletal muscle, which represents an active metabolic organ whose activities need to be determined. The purpose of our study was to detect relationships between skeletal muscle and adipose tissue inflammation with nonalcoholic fatty liver disease (NAFLD) and diabetes, as well as to explore associations with clinicopathological parameters.
4 Citations
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