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Yu Li
Peking Union Medical College Hospital
EndocrinologyAdipose tissueMetabolic syndromeDiabetes mellitusMedicine
6Publications
2H-index
4Citations
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Publications 10
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#1Yu Li (Peking Union Medical College Hospital)H-Index: 2
#2Dongmei Wang (Peking Union Medical College Hospital)H-Index: 1
Last. Shan Gao (Capital Medical University)H-Index: 5
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Abstract Background and aims The mechanisms by which passive smoking leads to cardiometabolic risks and the tissues involved still require elucidation. We aimed to evaluate the association of parental smoking exposure (PSE) with the secretion of adipocyte-derived hormones and cardiometabolic risk factors in Chinese children. Methods We included 3150 school children aged 6-18 years from the Beijing Child and Adolescent Metabolic Syndrome (BCAMS) study. Data on PSE and potential confounders were c...
1 CitationsSource
#1Ge Li (Peking Union Medical College Hospital)H-Index: 3
#2Yu Li (Peking Union Medical College Hospital)H-Index: 2
Last. Jie MiH-Index: 11
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Objective: A subset of normal-weight individuals appears predisposed to obesity-related cardiometabolic abnormalities. Studies of this metabolically obese, normal weight (MONW) phenotype in youth are scarce. We aimed to identify early environmental and genetic factors associated with MONW in children. Methods: Overall, 1475 normal-weight Chinese children aged 6-18 were recruited from the Beijing Children and Adolescents Metabolic Syndrome study cohort. Birthweight, childhood lifestyle, socio-eco...
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#1Yu LiH-Index: 2
#2Dan FengH-Index: 3
Last. Yonghui WangH-Index: 1
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Objective Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) may convey disparate risks of metabolic consequences. Fasting plasma glucose (FPG), while an expedient screening procedure, may not adequately assess metabolic risk, particularly among youths. In order to inform a strategy for screening Chinese youth for pre-diabetes, we examined the relative value of IFG versus IGT to define metabolic risk by assessing their association with insulin resistance, beta-cell dysfunction, ...
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#1Junling Fu (Peking Union Medical College Hospital)H-Index: 3
#2Lanwen Han (Capital Medical University)H-Index: 2
Last. Steven M. Willi (Children's Hospital of Philadelphia)H-Index: 27
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Summary Background and aims The relationship between vitamin D deficiency and metabolic syndrome (MS) remains controversial with relatively sparse data among youth. Therefore, we attempted to explicate the association of 25-hydroxyvitamin D [25(OH)D] levels with MS in Chinese adolescents and young adults. Methods A cohort of 559 subjects at elevated risk of MS were recruited at 14–28 years of age as a follow-up to the Beijing Child and Adolescent Metabolic Syndrome Study. Subjects underwent clin...
2 CitationsSource
#1Yu Li (Peking Union Medical College Hospital)H-Index: 2
#2M. G. Li (Peking Union Medical College Hospital)H-Index: 1
Last. Xinhua Xiao (Peking Union Medical College Hospital)H-Index: 12
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Objective To explore the effects of parental smoking (passive smoking) on glucose metabolism in children and adolescents. Methods A total of 3 510 subjects (including 1 577 boys and 1 573 girls) aged 6-18 years were recruited from the cohort of the Beijing Child and Adolescent Metabolic Syndrome (BCAMS) Study. Self-reported information on parental smoking, family history of diabetes mellitus, lifestyle and social-economic factors were collected by questionnaire. Fasting plasma glucose (FPG) and ...
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#1Junling Fu (Peking Union Medical College Hospital)H-Index: 3
#2Yonghui Wang (Capital Medical University)H-Index: 1
Last. Shan Gao (Capital Medical University)H-Index: 5
view all 13 authors...
Short sleep is an obesity risk factor, however, little is known about its interplay with genetic predisposition and pathways involved in obesity pathogenesis, especially in the longitudinal setting. We aimed to investigate a possible sleep-gene interaction for childhood obesity risk, and whether the interaction in childhood longitudinally contributes to obesity risk at a 10-year follow-up and further to test if there is any mediation through the leptin pathway. A total of 3211 children from Chin...
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#1Yunpeng Wu (Peking Union Medical College Hospital)
#2Xinting Yu (Harvard University)
Last. Ming Li (Peking Union Medical College Hospital)H-Index: 49
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Source
#1Junling Fu (Peking Union Medical College)H-Index: 3
#2Yu Li (Peking Union Medical College)H-Index: 2
Last. Steven M. Willi (Children's Hospital of Philadelphia)H-Index: 27
view all 13 authors...
Background The role of adipokine dysregulation in determining the metabolic fate of obesity is not well studied. We aimed to examine whether the matricellular protein osteonectin and the profiles of certain adipokines could differentiate metabolically healthy obese (MHO) versus metabolically unhealthy obese phenotypes in childhood. Methods and Results This study included 1137 obese children and 982 normal‐weight healthy (NWH) controls recruited from the BCAMS (Beijing Child and Adolescent Metabo...
2 CitationsSource
#1Ge Li (National Health and Family Planning Commission)H-Index: 3
#2Lanwen Han (Capital Medical University)H-Index: 2
Last. Steven M. Willi (Children's Hospital of Philadelphia)H-Index: 27
view all 9 authors...
Objective We aimed to assess haemoglobin A1c (HbA1c) for the diagnosis of pre-diabetes and diabetes in a population of Chinese youths at risk of metabolic syndrome. Setting Beijing, China. Participants A total of 581 subjects aged 14–28 years underwent evaluation including an oral glucose tolerance test (OGTT). Insulin sensitivity, β-cell function and a number of cardiovascular disease risk factors were evaluated. Receiver operating characteristic (ROC) curves were used to assess the screening e...
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Last. Ming LiH-Index: 2
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Supplementary information for manuscript: Birthweight and type 2 diabetes risk factors in children: the mediating role of adipose tissue
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