Iain Stewart
University of Nottingham
Publications 4
#1Jennifer T Cairns (University of Nottingham)
#2Anthony Habgood (University of Nottingham)H-Index: 8
Last.Amanda L. Tatler (University of Nottingham)H-Index: 11
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ETS domain-containing protein-1 (ELK1) is a transcriptional repressor important in regulating αvβ6 integrin expression. αvβ6 integrins activate the profibrotic cytokine Transforming Growth Factor β1 (TGFβ) and are increased in the alveolar epithelium in Idiopathic Pulmonary Fibrosis (IPF). IPF is a disease associated with ageing and therefore we hypothesised that aged animals lacking Elk1 globally would develop spontaneous fibrosis in organs where αvβ6-mediated TGFβ activation has been implicate...
#1Iain Stewart (University of Nottingham)H-Index: 1
#2Tricia M. McKeever (University of Nottingham)H-Index: 41
Last.Gauri Saini (University of Nottingham)H-Index: 6
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Idiopathic pulmonary fibrosis is a progressive and fatal interstitial lung disease. We aimed to determine if patient response to a palliative assessment survey could predict disease progression or death. We undertook a cross-sectional study in a UK clinical cohort of incident cases. Rasch-based methodology provided a disease distress value from an abridged 11 item model of the original 45 item survey. Distress values were compared with measures of lung function. Disease progression or mortality ...
#1Iain Stewart (University of Nottingham)H-Index: 1
#2Alison Leary (LSBU: London South Bank University)H-Index: 9
Last.Laila J. Tata (University of Nottingham)H-Index: 29
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© 2018 Elsevier Ltd Purpose: Health services across the world utilise advanced practice in cancer care. In the UK, lung cancer nurse specialists (LCNS) are recognised as key components of quality care in national guidelines, yet access to LCNS contact is unequal and some responsibilities are reportedly left undone. We assess whether any variation in working practices of LCNS is attributable to factors of the lung cancer service at the hospital trust. Method: Nationwide workload analysis of LCNS ...
#1Iain Stewart (University of Nottingham)H-Index: 1
#2A. Khakwani (University of Nottingham)H-Index: 8
Last.Laila J. Tata (University of Nottingham)H-Index: 29
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Objectives: Treatment choices for people with lung cancer may be influenced by contact and engagement with lung cancer nurse specialists (LCNSs). We investigated how service factors, LCNS workload, and LCNS working practices may influence the receipt of anticancer treatment. Materials and methods: English National Lung Cancer Audit data and inpatient Hospital Episode Statistics for 109,079 people with lung cancer surviving 30 days from diagnosis were linked along with LCNS workforce census data ...