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Iain Stewart
University of Nottingham
DistressInterstitial lung diseaseLungIdiopathic pulmonary fibrosisMedicine
16Publications
2H-index
9Citations
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Publications 13
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#1Iain Stewart (University of Nottingham)H-Index: 2
#2Henry Nanji (University of Nottingham)
Last. Gisli Jenkins (University of Nottingham)H-Index: 21
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Rationale: Circulating fibrocytes are elevated in idiopathic pulmonary fibrosis, but the relationship between fibrocyte level with lung function decline and clinical outcomes remains controversial. Objective: To provide evidence for the utility of circulating fibrocyte levels as a prognostic biomarker in pulmonary fibrosis. Methods: We tested associations between circulating fibrocyte levels, mortality, disease progression and longitudinal lung function in a well-defined prospective observationa...
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#1Fasihul Khan (University of Nottingham)
#2Laura Fabbri (University of Nottingham)
Last. Gisli Jenkins (University of Nottingham)H-Index: 21
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Background There is accumulating evidence for an overly activated immune response characterised by the release of pro-inflammatory cytokines in severe Covid-19. Suppression of the inflammatory response with immunomodulatory therapies may be a potential therapeutic strategy. We systematically review and assess the effectiveness of specific interleukin-1 and -6 inhibitors for the treatment of coronavirus-related infections. Methods Electronic databases, pre-print servers and clinical trial registr...
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#1Daniel Leisman (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 6
#2Michael O. Harhay (UPenn: University of Pennsylvania)H-Index: 20
Last. Rinaldo Bellomo (University of Melbourne)H-Index: 125
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Prediction models aim to use available data to predict a health state or outcome that has not yet been observed. Prediction is primarily relevant to clinical practice, but is also used in research, and administration. While prediction modeling involves estimating the relationship between patient factors and outcomes, it is distinct from casual inference. Prediction modeling thus requires unique considerations for development, validation, and updating. This document represents an effort from edit...
4 CitationsSource
#1Jennifer T. Cairns (University of Nottingham)
#2Anthony Habgood (University of Nottingham)H-Index: 8
Last. Amanda L. Tatler (University of Nottingham)H-Index: 13
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Abstract ETS domain-containing protein-1 (ELK1) is a transcriptional repressor important in regulating αvβ6 integrin expression. αvβ6 integrins activate the profibrotic cytokine Transforming Growth Factor β1 (TGFβ1) and are increased in the alveolar epithelium in idiopathic pulmonary fibrosis (IPF). IPF is a disease associated with aging and therefore we hypothesised that aged animals lacking Elk1 globally would develop spontaneous fibrosis in organs where αvβ6 mediated TGFβ activation has been ...
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#1Yvonne Nartey (Nottingham City Hospital)
#2I. Stewart (Nottingham City Hospital)
Last. Laila J. Tata (Nottingham City Hospital)H-Index: 31
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Abstract Objectives Healthcare systems increasingly recognise the importance of service users’ perspectives for improving care organisation and delivery. The English Cancer Patient Experience Survey (CPES) is carried out annually, however, its representativeness within cancer types is unknown. We have explored if the CPES results are representative of people with lung cancer. Materials and methods We linked cancer registry data across multiple sources to assess how CPES represents sociodemograph...
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#1R Kaur (University of Nottingham)
#2Iain Stewart (University of Nottingham)H-Index: 2
Last. Louise V. Wain (NIHR: National Institute for Health Research)H-Index: 38
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Idiopathic Pulmonary Fibrosis (IPF) is an uncommon but serious progressive fibrotic lung disease characterised by deteriorating symptoms, respiratory failure and death, often within 5 years from diagnosis. Up to 10% of patients with IPF have a family history of this disease, known as Familial Pulmonary Fibrosis (FPF). Prior genetic studies have identified rare variants in genes relating to telomere and epithelial function and are responsible for about 20% of FPF cases. To identify the missing he...
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#1Karmel Webb (Nottingham City Hospital)
#2Andrew W. Fogarty (Nottingham City Hospital)H-Index: 31
Last. Helen L. Barr (NUH: Nottingham University Hospitals NHS Trust)H-Index: 6
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Introduction. Pseudomonas aeruginosa is an important respiratory pathogen in cystic fibrosis (CF), which is associated with an accelerated decline in lung function, frequent pulmonary exacerbations and increased mortality. P. aeruginosa produces intercellular signalling molecules including 2-alkyl-4-quinolones (AQs), which regulate virulence-factor production and biofilm formation in the CF airways. Studies have shown that AQs are detectable in the sputum and plasma of adults with CF and chronic...
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#1Jennifer T. Cairns (University of Nottingham)
#1Jennifer T Cairns (University of Nottingham)
Last. Amanda L. Tatler (University of Nottingham)H-Index: 13
view all 13 authors...
ETS domain-containing protein-1 (ELK1) is a transcriptional repressor important in regulating αvβ6 integrin expression. αvβ6 integrins activate the profibrotic cytokine Transforming Growth Factor β1 (TGFβ) and are increased in the alveolar epithelium in Idiopathic Pulmonary Fibrosis (IPF). IPF is a disease associated with ageing and therefore we hypothesised that aged animals lacking Elk1 globally would develop spontaneous fibrosis in organs where αvβ6-mediated TGFβ activation has been implicate...
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