Donald G. Gilbert
Indiana University Bloomington
GenomeDrosophila melanogasterSpermGeneticsBiology
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Publications 15
#1Donald G. Gilbert (IU: Indiana University)H-Index: 13
#1Gilbert Dg (IU: Indiana University)H-Index: 1
Last. Donald G. Gilbert (IU: Indiana University)H-Index: 1
view all 1 authors...
Methods of transcript assembly and reduction filters are compared for recovery of reference gene sets of human, pig and plant, including longest coding sequence with EvidentialGene, longest transcript with CD-HIT, and most RNA-seq with TransRate. EvidentialGene methods are the most accurate in recovering reference genes, and maintain accuracy for alternate transcripts and paralogs. In comparison, filtering large over-assemblies by longest RNA measures, and most RNA-seq expression measures, disca...
2 CitationsSource
#1Donald G. Gilbert (IU: Indiana University Bloomington)H-Index: 13
1 CitationsSource
#1Alfredo Rago (University of Birmingham)H-Index: 6
#2Donald G. Gilbert (IU: Indiana University Bloomington)H-Index: 13
Last. John K. Colbourne (University of Birmingham)H-Index: 43
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Background Nasonia vitripennis is an emerging insect model system with haplodiploid genetics. It holds a key position within the insect phylogeny for comparative, evolutionary and behavioral genetic studies. The draft genomes for N. vitripennis and two sibling species were published in 2010, yet a considerable amount of transcriptiome data have since been produced thereby enabling improvements to the original (OGS1.2) annotated gene set. We describe and apply the EvidentialGene method used to pr...
17 CitationsSource
#1Rebecca P. Duncan (UM: University of Miami)H-Index: 10
#2Filip Husnik (Sewanee: The University of the South)H-Index: 8
Last. Alexandra Wilson (UM: University of Miami)H-Index: 22
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Symbiosis is well known to influence bacterial symbiont genome evolution and has recently been shown to shape eukaryotic host genomes. Intriguing patterns of host genome evolution, including remarkable numbers of gene duplications, have been observed in the pea aphid, a sap-feeding insect that relies on a bacterial endosymbiont for amino acid provisioning. Previously, we proposed that gene duplication has been important for the evolution of symbiosis based on aphid-specific gene duplication in a...
29 CitationsSource
#1John H. Werren (UR: University of Rochester)H-Index: 74
#2Stephen Richards (BCM: Baylor College of Medicine)H-Index: 49
Last. Richard A. Gibbs (BCM: Baylor College of Medicine)H-Index: 142
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We report here genome sequences and comparative analyses of three closely related parasitoid wasps: Nasonia vitripennis, N. giraulti, and N. longicornis. Parasitoids are important regulators of arthropod populations, including major agricultural pests and disease vectors, and Nasonia is an emerging genetic model, particularly for evolutionary and developmental genetics. Key findings include the identification of a functional DNA methylation tool kit; hymenopteran-specific genes including diverse...
619 CitationsSource
#1Alexander Stark (MIT: Massachusetts Institute of Technology)H-Index: 64
#2Michael F. Lin (MIT: Massachusetts Institute of Technology)H-Index: 23
Last. Manolis Kamvysselis (MIT: Massachusetts Institute of Technology)H-Index: 94
view all 46 authors...
Sequencing of multiple related species followed by comparative genomics analysis constitutes a powerful approach for the systematic understanding of any genome. Here, we use the genomes of 12 Drosophila species for the de novo discovery of functional elements in the fly. Each type of functional element shows characteristic patterns of change, or 'evolutionary signatures', dictated by its precise selective constraints. Such signatures enable recognition of new protein-coding genes and exons, spur...
511 CitationsSource
The Drosophila species comparative genome database DroSpeGe ( DroSpeGe/) provides genome researchers with rapid, usable access to 12 new and old Drosophila genomes, since its inception in 2004. Scientists can use, with minimal computing expertise, the wealth of new genome information for developing new insights into insect evolution. New genome assemblies provided by several sequencing centers have been annotated with known model organism gene homologies and gene predi...
39 CitationsSource
#1Donald G. Gilbert (IU: Indiana University Bloomington)H-Index: 13
euGenes is a genome information system and database that provides a common summary of eukaryote genes and genomes, at Seven popular genomes are included: human, mouse, fruitfly, Caenorhabditis elegans worm, Saccharomyces yeast, Arabidopsis mustard weed and zebrafish, with more planned. This information, automatically extracted and updated from several source databases, offers features not readily available through other genome databases to bioscientists loo...
44 CitationsSource
#1Mark H. GromkoH-Index: 12
#2Donald G. GilbertH-Index: 13
Last. Rollin C. RichmondH-Index: 23
view all 3 authors...
168 CitationsSource
#1Donald G. Gilbert (IU: Indiana University Bloomington)H-Index: 13
#2Rollin C. Richmond (IU: Indiana University Bloomington)H-Index: 23
Last. Kathy B. Sheehan (IU: Indiana University Bloomington)H-Index: 21
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Esterase 6 (EST 6) inDrosophila melanogaster is a male reproductive enzyme transferred to females as a component of the seminal fluid [Richmond, R. C., Gilbert, D. G., Sheehan, K. B., Gromko, M. H., and Butterworth, F. W. (1980).Science207:1483–1485]. Here we report investigations into the relation between EST 6 and remating by females. EST 6 activity in a strain selected for decreased time to remating is increased over control levels. Inseminated females remated to males carrying null or active...
40 CitationsSource