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Edward A. Ruiz-Narváez
University of Michigan
104Publications
22H-index
1,647Citations
Publications 104
Newest
Published on Jan 1, 2019in Environmental Epigenetics
Yue Wu (UM: University of Michigan), Brisa N. Sánchez33
Estimated H-index: 33
(UM: University of Michigan)
+ 6 AuthorsKaren E. Peterson54
Estimated H-index: 54
(UM: University of Michigan)
Published on Dec 1, 2018in Breast Cancer Research5.68
Jeannette T. Bensen23
Estimated H-index: 23
(UNC: University of North Carolina at Chapel Hill),
Misa Graff22
Estimated H-index: 22
(UNC: University of North Carolina at Chapel Hill)
+ 19 AuthorsChristopher A. Haiman78
Estimated H-index: 78
(SC: University of Southern California)
Background MicroRNAs (miRNAs) regulate gene expression and influence cancer. Primary transcripts of miRNAs (pri-miRNAs) are poorly annotated and little is known about the role of germline variation in miRNA genes and breast cancer (BC). We sought to identify germline miRNA variants associated with BC risk and tumor subtype among African-American (AA) women.
Published on Dec 1, 2018in Breast Cancer Research5.68
Emma H. Allott15
Estimated H-index: 15
(UNC: University of North Carolina at Chapel Hill),
Joseph Geradts50
Estimated H-index: 50
(Harvard University)
+ 24 AuthorsRochelle Payne Ondracek4
Estimated H-index: 4
(Roswell Park Cancer Institute)
Background Breast cancer subtype can be classified using standard clinical markers (estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2)), supplemented with additional markers. However, automated biomarker scoring and classification schemes have not been standardized. The aim of this study was to optimize tumor classification using automated methods in order to describe subtype frequency in the African American Breast Cancer Epidemiology and Risk...
Published on Nov 1, 2018in Journal of Human Genetics3.54
José M. Uribe-Salazar1
Estimated H-index: 1
(UCR: University of Costa Rica),
Julie R. Palmer38
Estimated H-index: 38
(BU: Boston University)
+ 2 AuthorsEdward A. Ruiz-Narváez22
Estimated H-index: 22
(UM: University of Michigan)
African American women are disproportionately affected by type 2 diabetes. Genetic factors may explain part of the excess risk. More than 100 genetic variants have been associated with risk of type 2 diabetes, but most studies have been conducted in white populations. Two genome-wide association studies (GWAS) in African Americans have identified three novel genetic variants only. We conducted admixture mapping using 2918 ancestral informative markers in 2632 cases of type 2 diabetes, and 2596 c...
Published on Jul 1, 2018in American Journal of Epidemiology4.47
Stephen A. Haddad16
Estimated H-index: 16
(BU: Boston University),
Edward A. Ruiz-Narváez22
Estimated H-index: 22
(BU: Boston University)
+ 3 AuthorsJulie R. Palmer38
Estimated H-index: 38
(BU: Boston University)
Published on Jul 1, 2018in Human Genetics5.21
Heather M. Ochs-Balcom22
Estimated H-index: 22
(UB: University at Buffalo),
Holly Shaw1
Estimated H-index: 1
(UB: University at Buffalo)
+ 4 AuthorsEdward A. Ruiz-Narváez22
Estimated H-index: 22
(UM: University of Michigan)
Several genome-wide association studies (GWAS) have identified genetic variants associated with birth weight. To date, however, most GWAS of birth weight have focused primarily on European ancestry samples even though prevalence of low birth weight is higher among African-Americans. We conducted admixture mapping using 2918 ancestral informative markers in 2596 participants of the Black Women’s Health Study, with the goal of identifying novel genomic regions where local African ancestry is assoc...
Published on Jun 7, 2018in PLOS Genetics5.22
Song Yao20
Estimated H-index: 20
,
Chi Chen Hong13
Estimated H-index: 13
+ 14 AuthorsLara E. Sucheston-Campbell12
Estimated H-index: 12
(OSU: Ohio State University)
Selection pressure due to exposure to infectious pathogens endemic to Africa may explain distinct genetic variations in immune response genes. However, the impact of those genetic variations on human immunity remains understudied, especially within the context of modern lifestyles and living environments, which are drastically different from early humans in sub Saharan Africa. There are few data on population differences in constitutional immune environment, where genetic ancestry and environmen...
Published on Jan 16, 2018in Cancer Epidemiology, Biomarkers & Prevention5.06
Chi-Chen Hong12
Estimated H-index: 12
(Roswell Park Cancer Institute),
Lara E. Sucheston-Campbell12
Estimated H-index: 12
(OSU: Ohio State University)
+ 17 AuthorsTing-Yuan David Cheng9
Estimated H-index: 9
(UF: University of Florida)
Background: Constitutional immunity shaped by exposure to endemic infectious diseases and parasitic worms in Sub-Saharan Africa may play a role in the etiology of breast cancer among African American (AA) women. Methods: A total of 149,514 gene variants in 433 genes across 45 immune pathways were analyzed in the AMBER consortium among 3,663 breast cancer cases and 4,687 controls. Gene-based pathway analyses were conducted using the adaptive rank truncated product statistic for overall breast can...
Published on Jan 1, 2018in American Journal of Human Biology1.44
Jorge Azofeifa7
Estimated H-index: 7
(UCR: University of Costa Rica),
Edward A. Ruiz-Narváez22
Estimated H-index: 22
(BU: Boston University)
+ 2 AuthorsLuis Rosero-Bixby25
Estimated H-index: 25
(UCR: University of Costa Rica)
Objectives The aim of this study was to address the hypothesis that Amerindian ancestry is associated with extended longevity in the admixed population of Nicoya, Costa Rica. The Nicoya Peninsula of Costa Rica has been considered a “longevity island,” particularly for males. Methods We estimated Amerindian ancestry using 464 ancestral informative markers in 20 old Nicoyans aged ≥99 years, and 20 younger Nicoyans (60-65 years). We used logistic regression to estimate odds ratio (OR) and 95% confi...
Published on Nov 1, 2017in Human Genetics5.21
Jacklyn N. Hellwege6
Estimated H-index: 6
(VUMC: Vanderbilt University Medical Center),
Janina M. Jeff11
Estimated H-index: 11
(ISMMS: Icahn School of Medicine at Mount Sinai)
+ 24 AuthorsEdward A. Ruiz-Narváez22
Estimated H-index: 22
(BU: Boston University)
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