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Edward A. Ruiz-Narváez
Boston University
105Publications
24H-index
1,748Citations
Publications 105
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#1Yue Wu (UM: University of Michigan)H-Index: 1
#2Brisa N. Sánchez (UM: University of Michigan)H-Index: 35
Last.Karen E. Peterson (UM: University of Michigan)H-Index: 55
view all 9 authors...
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#1Jeannette T. Bensen (UNC: University of North Carolina at Chapel Hill)H-Index: 24
#2Misa Graff (UNC: University of North Carolina at Chapel Hill)H-Index: 23
Last.Andrew F. Olshan (UNC: University of North Carolina at Chapel Hill)H-Index: 59
view all 22 authors...
Background MicroRNAs (miRNAs) regulate gene expression and influence cancer. Primary transcripts of miRNAs (pri-miRNAs) are poorly annotated and little is known about the role of germline variation in miRNA genes and breast cancer (BC). We sought to identify germline miRNA variants associated with BC risk and tumor subtype among African-American (AA) women.
2 CitationsSource
#1Emma H. Allott (UNC: University of North Carolina at Chapel Hill)H-Index: 15
#2Joseph Geradts (Harvard University)H-Index: 51
Last.Melissa A. Troester (UNC: University of North Carolina at Chapel Hill)H-Index: 4
view all 27 authors...
Background Breast cancer subtype can be classified using standard clinical markers (estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2)), supplemented with additional markers. However, automated biomarker scoring and classification schemes have not been standardized. The aim of this study was to optimize tumor classification using automated methods in order to describe subtype frequency in the African American Breast Cancer Epidemiology and Risk...
4 CitationsSource
#1José M. Uribe-Salazar (UCR: University of Costa Rica)H-Index: 1
#2Julie R. Palmer (BU: Boston University)H-Index: 39
Last.Edward A. Ruiz-Narváez (UM: University of Michigan)H-Index: 24
view all 5 authors...
African American women are disproportionately affected by type 2 diabetes. Genetic factors may explain part of the excess risk. More than 100 genetic variants have been associated with risk of type 2 diabetes, but most studies have been conducted in white populations. Two genome-wide association studies (GWAS) in African Americans have identified three novel genetic variants only. We conducted admixture mapping using 2918 ancestral informative markers in 2632 cases of type 2 diabetes, and 2596 c...
1 CitationsSource
#1Stephen A. Haddad (BU: Boston University)H-Index: 16
#2Edward A. Ruiz-Narváez (BU: Boston University)H-Index: 24
Last.Julie R. Palmer (BU: Boston University)H-Index: 39
view all 6 authors...
1 CitationsSource
#1Heather M. Ochs-Balcom (UB: University at Buffalo)H-Index: 22
#2Holly Shaw (UB: University at Buffalo)H-Index: 1
Last.Edward A. Ruiz-Narváez (UM: University of Michigan)H-Index: 24
view all 7 authors...
Several genome-wide association studies (GWAS) have identified genetic variants associated with birth weight. To date, however, most GWAS of birth weight have focused primarily on European ancestry samples even though prevalence of low birth weight is higher among African-Americans. We conducted admixture mapping using 2918 ancestral informative markers in 2596 participants of the Black Women’s Health Study, with the goal of identifying novel genomic regions where local African ancestry is assoc...
1 CitationsSource
#1Song YaoH-Index: 20
#2Chi Chen HongH-Index: 14
Last.Christine B. AmbrosoneH-Index: 65
view all 17 authors...
Selection pressure due to exposure to infectious pathogens endemic to Africa may explain distinct genetic variations in immune response genes. However, the impact of those genetic variations on human immunity remains understudied, especially within the context of modern lifestyles and living environments, which are drastically different from early humans in sub Saharan Africa. There are few data on population differences in constitutional immune environment, where genetic ancestry and environmen...
3 CitationsSource
#1Chi-Chen Hong (Roswell Park Cancer Institute)H-Index: 13
#2Lara E. Sucheston-Campbell (OSU: Ohio State University)H-Index: 13
Last.Christine B. Ambrosone (Roswell Park Cancer Institute)H-Index: 65
view all 20 authors...
Background: Constitutional immunity shaped by exposure to endemic infectious diseases and parasitic worms in Sub-Saharan Africa may play a role in the etiology of breast cancer among African American (AA) women. Methods: A total of 149,514 gene variants in 433 genes across 45 immune pathways were analyzed in the AMBER consortium among 3,663 breast cancer cases and 4,687 controls. Gene-based pathway analyses were conducted using the adaptive rank truncated product statistic for overall breast can...
3 CitationsSource
#1Jorge Azofeifa (UCR: University of Costa Rica)H-Index: 10
#2Edward A. Ruiz-Narváez (BU: Boston University)H-Index: 24
Last.Luis Rosero-Bixby (UCR: University of Costa Rica)H-Index: 26
view all 5 authors...
Objectives The aim of this study was to address the hypothesis that Amerindian ancestry is associated with extended longevity in the admixed population of Nicoya, Costa Rica. The Nicoya Peninsula of Costa Rica has been considered a “longevity island,” particularly for males. Methods We estimated Amerindian ancestry using 464 ancestral informative markers in 20 old Nicoyans aged ≥99 years, and 20 younger Nicoyans (60-65 years). We used logistic regression to estimate odds ratio (OR) and 95% confi...
2 CitationsSource
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