Pramod Dhakal
University of Missouri
EndocrinologyAndrologyActivin receptorPregnancyBiology
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Publications 4
#1Harriet C. Fitzgerald (MU: University of Missouri)H-Index: 1
#2Pramod Dhakal (MU: University of Missouri)H-Index: 2
Last. Thomas E. Spencer (MU: University of Missouri)H-Index: 86
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The human endometrium is essential in providing the site for implantation and maintaining the growth and survival of the conceptus. An unreceptive endometrium and disrupted maternal−conceptus interactions can cause infertility due to pregnancy loss or later pregnancy complications. Despite this, the role of uterine glands in first trimester human pregnancy is little understood. An established organoid protocol was used to generate and comprehensively analyze 3-dimensional endometrial epithelial ...
4 CitationsSource
#1Susanta K. Behura (MU: University of Missouri)H-Index: 26
#1Susanta K. Behura (MU: University of Missouri)H-Index: 6
Last. Thomas E. Spencer (MU: University of Missouri)H-Index: 86
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Abstract The placenta plays a critical role in mammalian reproduction. Although it is a transient organ, its function is indispensable to communication between the mother and fetus, and supply of nutrients and oxygen to the growing fetus. During pregnancy, the placenta is vulnerable to various intrinsic and extrinsic conditions which can result in increased risk of fetal neurodevelopmental disorders as well as fetal death. The placenta controls the neuroendocrine secretion in the brain as a mean...
2 CitationsSource
#1Neekun Sharma (MU: University of Missouri)H-Index: 3
#2Rishabh Dev (MU: University of Missouri)H-Index: 3
Last. Chetan P. Hans (MU: University of Missouri)H-Index: 3
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Abdominal aortic aneurysm (AAA) is characterized by transmural infiltration of myeloid cells at the vascular injury site. Previously, we reported preventive effects of Notch deficiency on the development of AAA by reduction of infiltrating myeloid cells. In this study, we examined if Notch inhibition attenuates the progression of pre-established AAA and potential implications. Pharmacological Notch inhibitor (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester; DAPT) was admi...
3 CitationsSource
#1Yuki Kimura (Obihiro University of Agriculture and Veterinary Medicine)H-Index: 3
#2Motoki Sasaki (Obihiro University of Agriculture and Veterinary Medicine)H-Index: 14
Last. Yasuo Nambo (Obihiro University of Agriculture and Veterinary Medicine)H-Index: 17
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: Activin is secreted from equine uterine glands and plays important roles in establishment and maintenance of pregnancy in mares. This study aimed to localize activin receptors (ActRs) IA/B and IIA/B using immunohistochemistry in the uteroplacental tissues of seven pregnant Thoroughbred mares. At the time of tissue collection, the mares were at the following days of pregnancy: 88, 120, 161, 269, 290, 313, and 335 days. We fixed the uteroplacental tissues in 4% paraformaldehyde and obtained seri...