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Martin R. Jadus
University of California, Berkeley
85Publications
24H-index
1,387Citations
Publications 85
Newest
#1Neil HoaH-Index: 16
#2Lisheng GeH-Index: 9
Last.Martin R. Jadus (University of California, Berkeley)H-Index: 24
view all 7 authors...
ABSTRACTObjective: Temozolomide (TMZ) improves Glioblastoma Multiforme (GBM) patient survival. The invasive behavior of the glioma cells is the cause of GBM relapse. The glioma BK ion channel (gBK) may provide glioma cells with a mechanism to invade surrounding tissue. gBK contains epitopes that cytolytic T lymphocytes (CTLs) can recognize and kill glioma cells. Fascin-1 is an actin crosslinking molecule that supports microvilli; these membrane protrusions provide a physical defense against CTLs...
#1Lisheng GeH-Index: 9
#2Neil HoaH-Index: 16
Last.Martin R. Jadus (VA: United States Department of Veterans Affairs)H-Index: 24
view all 7 authors...
Objective: Our group has previously observed that in patients with small-cell lung cancers (SCLCs), the expression of a tumorantigen, glioma big potassium (gBK) ion channel, is higher at the time of death than when the cancer is first treated by surgicalresection. This study aimed to determine whether this dichotomy was common in other potential lung tumor antigens byexamining the same patient samples using our more extensive profile analysis of tumor-antigen precursor protein (TAPP). Wethen tes...
#1Benjamin H. Beck (UAB: University of Alabama at Birmingham)H-Index: 18
#2Hyunggoon Kim (UAB: University of Alabama at Birmingham)H-Index: 1
Last.Lawrence S. Lamb (UAB: University of Alabama at Birmingham)H-Index: 1
view all 11 authors...
Human γδ T cells are potent effectors against glioma cell lines in vitro and in human/mouse xenograft models of glioblastoma, however, this effect has not been investigated in an immunocompetent mouse model. In this report, we established GL261 intracranial gliomas in syngeneic WT C57BL/6 mice and measured circulating γδ T cell count, phenotype, Vγ/Vδ repertoire, tumor histopathology, NKG2D ligands expression, and T cell invasion at day 10–12 post-injection and at end stage. Circulating γδ T cel...
#1Neil HoaH-Index: 16
#2Lisheng GeH-Index: 9
Last.Martin R. JadusH-Index: 24
view all 9 authors...
Cancer cells derived from Glioblastoma multiforme possess membranous protrusions allowing these cells to infiltrate surrounding tissue, while resisting lymphocyte cytotoxicity. Microvilli and filopodia are supported by actin filaments cross-linked by fascin. Fascin-1 was genetically silenced within human U251 glioma cells; these knock-down glioma cells lost their microvilli/filopodia. The doubling time of these fascin-1 knock-down cells was doubled that of shRNA control U251 cells. Fascin-1 knoc...
#1Neil HoaH-Index: 16
#2Lisheng GeH-Index: 9
view all 9 authors...
Cancer cells derived from Glioblastoma multiforme possess membranous protrusions allowing these cells to infiltrate surrounding tissue, while resisting lymphocyte cytotoxicity. Microvilli and filopodia are supported by actin filaments cross-linked by fascin. Fascin-1 was genetically silenced within human U251 glioma cells; these knock- down glioma cells lost their microvilli/filopodia. The doubling time of these fascin-1 knock-down cells was doubled that of shRNA control U251 cells. Fascin-1 kno...
#1Lisheng GeH-Index: 9
#2Neil HoaH-Index: 16
Last.Martin R. JadusH-Index: 24
view all 8 authors...
Abstract The Big Potassium (BK) ion channel is commonly known by a variety of names (Maxi-K, KCNMA1, slo, stretch-activated potassium channel, KCa1.1). Each name reflects a different physical property displayed by this single ion channel. This transmembrane channel is found on nearly every cell type of the body and has its own distinctive roles for that tissue type. The BKα channel contains the pore that releases potassium ions from intracellular stores. This ion channel is found on the cell mem...
#1Ahmed M. Aref (Modern Sciences and Arts University)H-Index: 6
#2Neil HoaH-Index: 16
Last.Martin R. JadusH-Index: 24
view all 9 authors...
Immunotherapy for human hepatocellular cancer (HCC) is slowly making progress towards treating these fatal cancers. The identification of new antigens can improve this approach. We describe a possible new antigen, Hepatocellular Carcinoma-associated Antigen-519/ Targeting Protein for Xklp-2 [HCA519/Tpx2], for HCC that might be beneficial for T cell specific HCC immunotherapy. HCC was studied for the expression for 15 tumor-associated antigens considered useful for immunotherapy within three HCC ...
#1Neil HoaH-Index: 16
#2Lisheng GeH-Index: 9
Last.Martin R. JadusH-Index: 24
view all 13 authors...
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Big Potassium (BK) ion channels have several splice variants. One splice variant initially described within human glioma cells is called the glioma BK channel (gBK). This isoform consists of 33 amino acids inserted into the intracellular region of the BK ion channel. Using a gBK-specific antibody, we detected gBK within 3 human small cell lung cancer (SCLC) lines. Patch clamping revealed that functional membrane channels were ...
Glioblastoma Multiforme (GMB) is the most aggressive primary brain tumor with poor survival rates and universal recurrence despite aggressive treatments. Recent research suggested that GBM has multiple glioma cell populations, some of which are organized in a stem cell hierarchical order with different stages of differention. Evidence indicated that recurrence is due to a development or persistance of a subpopulation of these tumor cells which are inherently resistant to treatment and these were...
#1Ahmed M. ArefH-Index: 6
#2Neil HoaH-Index: 16
Last.Martin R. Jadus (VA: United States Department of Veterans Affairs)H-Index: 24
view all 9 authors...
OncoTargets and Therapy Dovepress open access to scientific and medical research Original Research Open Access Full Text Article HCA519/TPX2: a potential T-cell tumor- associated antigen for human hepatocellular carcinoma This article was published in the following Dove Press journal: OncoTargets and Therapy 13 June 2014 Number of times this article has been viewed Ahmed M Aref 1–3 Neil T Hoa 3 Lisheng Ge 3 Anshu Agrawal 4 Maria Dacosta-Iyer 5,6 Nils Lambrecht 5,6 Yi Ouyang 5,6 Andrew N Cornfort...
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