Abigail Ward
Harvard University
Publications 8
#1Andrew L. Hong (Broad Institute)H-Index: 8
#2Yuen-Yi Tseng (Broad Institute)H-Index: 6
Last.William C. Hahn (Broad Institute)H-Index: 108
view all 41 authors...
Renal medullary carcinoma (RMC for short) is a rare type of kidney cancer that affects teenagers and young adults. These patients are usually of African descent and carry one of the two genetic changes that cause sickle cell anemia. RMC is an aggressive disease without effective treatments and patients survive, on average, for only six to eight months after their diagnosis. Recent genetic studies found that most RMC cells have mutations that prevent them from producing a protein called SMARCB1. ...
1 CitationsSource
#1Andrew L. Hong (Broad Institute)H-Index: 8
#2Yuen-Yi Tseng (Broad Institute)H-Index: 6
Last.William C. Hahn (Broad Institute)H-Index: 108
view all 41 authors...
#1Abigail WardH-Index: 4
Last.Arnaud Le MenachH-Index: 18
view all 15 authors...
Integrating seasonal malaria chemoprevention (SMC), recommended by the WHO since 2012 to prevent malaria infection, with nutrition interventions may improve health outcomes and operational efficiencies. This study assessed the effects of co-packaging interventions on distribution coverage, nutrition, and clinical malaria outcomes in northern Nigeria. From August to November 2014, community volunteers delivered sulfadoxine-pyrimethamine and amodiaquine (SP-AQ) door-to-door each month to approxima...
#1Kelly Klega (Harvard University)H-Index: 2
#2Alma Imamovic-Tuco (Harvard University)H-Index: 2
Last.Brian D. Crompton (Harvard University)H-Index: 11
view all 15 authors...
ObjectiveLiquid biopsies are being rapidly used in adult cancers as new biomarkers of disease. Circulating tumor DNA (ctDNA) levels have been reported to be proportional to disease burden, correlat...
7 CitationsSource
#1Bruce M. Wollison (Harvard University)H-Index: 5
#2Edwin Thai (Harvard University)H-Index: 1
Last.Brian D. Crompton (Broad Institute)H-Index: 11
view all 10 authors...
Objectives Liquid biopsy technologies allow non-invasive tumor profiling for patients with solid tumor malignancies by sequencing circulating tumor DNA. These studies may be useful in risk-stratification, monitoring for relapse, and understanding tumor evolution. The quality of DNA obtained for these studies is improved when blood samples are collected in tubes that stabilizing white blood cells (WBC). However, ongoing germline research in pediatric oncology generally requires obtaining blood sa...
#1Kathleen MaloneyH-Index: 5
#2Abigail WardH-Index: 4
Last.Sigsbert MkudeH-Index: 5
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Background Tanzania has seen a reduction in the fraction of fevers caused by malaria, likely due in part to scale-up of control measures. While national guidelines require parasite-based diagnosis prior to treatment, it is estimated that more than half of suspected malaria treatment-seeking in Tanzania initiates in the private retail sector, where diagnosis by malaria rapid diagnostic test (RDT) or microscopy is illegal. This pilot study investigated whether the introduction of RDTs into Accredi...
6 CitationsSource
#1Theodoor VisserH-Index: 4
#2Katia BruxvoortH-Index: 11
Last.Clare I. R. ChandlerH-Index: 23
view all 32 authors...
Many patients with malaria-like symptoms seek treatment in private medicine retail outlets (PMR) that distribute malaria medicines but do not traditionally provide diagnostic services, potentially leading to overtreatment with antimalarial drugs. To achieve universal access to prompt parasite-based diagnosis, many malaria-endemic countries are considering scaling up malaria rapid diagnostic tests (RDTs) in these outlets, an intervention that may require legislative changes and major investments ...
11 CitationsSource
#2Deepika KandulaH-Index: 5
Last.Justin M. CohenH-Index: 26
view all 5 authors...
Background: Despite its importance in control and elimination settings, malaria diagnosis rates tend to be low in many African countries. An operational research pilot was conducted in Namibia to identify the key barriers to appropriate diagnosis of malaria in public health facilities and to evaluate the effectiveness of various training approaches in improving the uptake and adherence to rapid diagnostic tests (RDTs). Methods: After identifying case management weaknesses through focus group dis...
4 CitationsSource