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S.M. Bleker
University of Amsterdam
15Publications
4H-index
93Citations
Publications 14
Newest
#1Noémie Kraaijpoel (UvA: University of Amsterdam)H-Index: 6
#2S.M. Bleker (UvA: University of Amsterdam)H-Index: 4
Last.Marcello Di NisioH-Index: 30
view all 21 authors...
PURPOSEPulmonary embolism is incidentally diagnosed in up to 5% of patients with cancer on routine imaging scans. The clinical relevance and optimal therapy for incidental pulmonary embolism, parti...
3 CitationsSource
#1Noémie KraaijpoelH-Index: 6
#2S.M. BlekerH-Index: 4
Last.Marcello Di NisioH-Index: 30
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Source
#2A. BuchmullerH-Index: 9
Last.S. MidddeldorpH-Index: 47
view all 10 authors...
Source
#1Nick van EsH-Index: 17
#2S.M. BlekerH-Index: 4
Last.P. M. M. BossuytH-Index: 110
view all 11 authors...
Essentials The Constans score and D-dimer can rule out upper extremity deep vein thrombosis without imaging. We evaluated the performance of an extended Constans score and an age-adjusted D-dimer threshold. The extended Constans score did not increase the efficiency compared to the original score. Age-adjusted D-dimer testing safely increased the efficiency by 4%, but this needs validation. SummaryBackground Among patients with clinically suspected upper extremity deep vein thrombosis (UEDVT), a...
4 CitationsSource
#1S.M. BlekerH-Index: 4
#2L.F.M. BeenenH-Index: 1
Last.A. RuttenH-Index: 1
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Abstract Background The incidence of incidental pulmonary embolism (IPE) in cancer patients is increasing. There is scant information on the interobserver agreement among radiologists about the diagnosis of distal incidental clots and the actual radiologic extension of IPE. Methods A total of 88 contrast-enhanced computed tomography (CT) scans of cancer patients with IPE were reassessed blindly by two expert thoracic radiologists. First, 62 scans were reassessed and the interobserver agreement o...
3 CitationsSource
#1S.M. BlekerH-Index: 4
#2Nick van EsH-Index: 17
Last.Marcello Di NisioH-Index: 30
view all 21 authors...
Essentials Few data exist on outcome of upper extremity deep and superficial vein thrombosis (UEDVT and UESVT). We followed 102 and 55 patients with UEDVT or UESVT, respectively, for a median of 3.5 years. Risk of recurrent venous thromboembolism was low in both diseases, and the mortality high. Postthrombotic symptoms were infrequent and cancer patients had a higher risk of recurrent VTE. Background There is scant information on the optimal management and clinical outcome of deep and superficia...
12 CitationsSource
#1Marjolein P. A. Brekelmans (UvA: University of Amsterdam)H-Index: 9
#2S.M. Bleker (UvA: University of Amsterdam)H-Index: 4
Last.Alexander T. Cohen (Guy's and St Thomas' NHS Foundation Trust)H-Index: 22
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Edoxaban is a once-daily direct oral anticoagulant (DOAC). The Hokusai-VTE study revealed that, after initial treatment with heparin, edoxaban was non-inferior to and safer than vitamin K antagonists (VKA) in the prevention of recurrent deep-vein thrombosis and pulmonary embolism. This is the first report on the clinical relevance and management of bleeding events with edoxaban. All major bleeding events were classified blindly by three study-independent adjudicators. Pre-defined criteria were u...
9 CitationsSource
#1Arina J. ten Cate-Hoek (UM: Maastricht University)H-Index: 64
#2Jeffrey I. Weitz (McMaster University)H-Index: 90
Last.Harry R. Büller (UvA: University of Amsterdam)H-Index: 92
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a Maastricht University Medical Center, Laboratory for Clinical Thrombosis and Hemostasis, Cardiovascular Research Institute Maastricht (CARIM), Netherlands b Thrombosis Center, USA c McMaster University and Thrombosis and Atherosclerosis Research Institute, Canada d Vanderbilt University, Department of Pathology, Microbiology and Immunology, Nashville, USA e University of Groningen, University Medical Center Groningen, Department of Hematology, Netherlands f University of Leeds, Division of Car...
1 CitationsSource
#1Nick van Es (UvA: University of Amsterdam)H-Index: 17
#2Marcello Di NisioH-Index: 30
Last.Gary E. Raskob (OU: University of Oklahoma)H-Index: 73
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Direct oral anticoagulants may be effective and safe for treatment of venous thromboembolism (VTE) in cancer patients, but they have not been compared with low-molecular-weight heparin (LMWH), the current recommended treatment for these patients. The Hokusai VTE-cancer study is a randomised, open-label, clinical trial to evaluate whether edoxaban, an oral factor Xa inhibitor, is non-inferior to LMWH for treatment of VTE in patients with cancer. We present the rationale and some design features o...
59 CitationsSource
#1S.M. BlekerH-Index: 4
#2Nick van EsH-Index: 17
Last.Marcello Di NisioH-Index: 30
view all 21 authors...
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