David J. Nutt
Imperial College London
Publications 1160
Abstract Introduction Given the low efficacy of smoking cessation methods, an experimental medicine model indicating smoking abstinence would be of great benefit to the development of new treatments. Hence the sensitivity of cognitive tasks and ambulatory craving measures to smoking abstinence were investigated. Methods Cognitive tasks and ambulatory ratings of craving were assessed for sensitivity to acute abstinence (experiment 1), and nicotine replacement therapy administration (NRT) (experim...
Studying transitions in and out of the altered state of consciousness caused by intravenous (IV) N,N-Dimethyltryptamine (DMT - a fast-acting tryptamine psychedelic) offers a safe and powerful means of advancing knowledge on the neurobiology of conscious states. Here we sought to investigate the effects of IV DMT on the power spectrum and signal diversity of human brain activity (6 female, 7 male) recorded via multivariate EEG, and plot relationships between subjective experience, brain activity ...
Positron emission tomography (PET) enables non-invasive estimation of neurotransmitter fluctuations in the living human brain. While these methods have been applied to dopamine and some other transmitters, estimation of 5-hydroxytryptamine (5-HT; Serotonin) release has proved to be challenging. Here we demonstrate the utility of the novel 5-HT2A receptor agonist radioligand, [11C]CIMBI-36, and a d-amphetamine challenge to evaluate synaptic 5-HT changes in the living human brain. Seventeen health...
#1Carla Pallavicini (UBA: University of Buenos Aires)H-Index: 4
#2Martina G. Vilas (MPG: Max Planck Society)H-Index: 2
Last.Enzo Tagliazucchi (UBA: University of Buenos Aires)H-Index: 24
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Abstract Classic serotonergic psychedelics are remarkable for their capacity to induce reversible alterations in consciousness of the self and the surroundings, mediated by agonism at serotonin 5-HT2A receptors. The subjective effects elicited by dissociative drugs acting as N-methyl-D-aspartate (NMDA) antagonists (e.g. ketamine and phencyclidine) overlap in certain domains with those of serotonergic psychedelics, suggesting some potential similarities in the brain activity patterns induced by b...
2 CitationsSource
#1Louis-David Lord (University of Oxford)H-Index: 8
#2Paul Expert (Imperial College London)H-Index: 11
Last.Joana Cabral (University of Oxford)H-Index: 13
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Abstract Growing evidence from the dynamical analysis of functional neuroimaging data suggests that brain function can be understood as the exploration of a repertoire of metastable connectivity patterns (‘functional brain networks’), which potentially underlie different mental processes. The present study characterizes how the brain's dynamical exploration of resting-state networks is rapidly modulated by intravenous infusion of psilocybin, a tryptamine psychedelic found in “magic mushrooms”. W...
1 CitationsSource
#1Heather Wilson ('KCL': King's College London)H-Index: 8
#2George Dervenoulas ('KCL': King's College London)H-Index: 3
Last.Marios Politis ('KCL': King's College London)H-Index: 36
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#1Kim P. C. Kuypers (UM: Maastricht University)H-Index: 21
#2Livia Ng (UCL: University College London)H-Index: 1
Last.David J. Nutt (Imperial College London)H-Index: 86
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Background:In the past few years, the issue of ‘microdosing’ psychedelics has been openly discussed in the public arena where claims have been made about their positive effect on mood state and cog...
2 CitationsSource
1 CitationsSource
#1Liam J. Nestor (University of Cambridge)H-Index: 9
#2Louise M. Paterson (Imperial College London)H-Index: 9
Last.David J. Nutt (Imperial College London)H-Index: 86
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2 CitationsSource
#1Ann G. Hayes (University of Hertfordshire)H-Index: 20
#2David J. Nutt (Imperial College London)H-Index: 86