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André O'Reilly Beringhs
University of Connecticut
ChemistryPelletsChromatographyDosage formDissolution
17Publications
5H-index
55Citations
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Publications 19
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Abstract A Quality by Design approach was taken to assess the influence of several formulation parameters on critical quality attributes of liquisolid pellets (LPs) obtained by extrusion-spheronization. Two mixture experimental designs were used, one for each of the non-volatile solvents (NVS) studied: Kolliphor® EL or PEG 400. The studied parameters were the concentrations of NVS (A-Kolliphor® EL, 0–40% w/w; or PEG 400, 0–31.1% w/w), coating material (B-crospovidone, 0–50.3% w/w) and carrier (C...
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Our research group has pioneered the development of liquisolid pellets as a new drug delivery system targeting at the improvement of the dissolution rates of poorly water-soluble drugs, combining the technological and biopharmaceutical advantages of both multiparticulate and liquisolid systems. Recently, Lam and collaborators claimed the invention of “liqui-pellets” as “the emerging next-generation oral dosage form which stems from liquisolid concept in combination with pelletization technology”...
1 CitationsSource
#1André O'Reilly Beringhs (UConn: University of Connecticut)H-Index: 5
Last. Xiuling LuH-Index: 16
view all 3 authors...
Abstract Cancer is a major health burden due to the overall high mortality and physical impairment associated with it. Several factors play relevant roles in cancer prognosis, including the progression stage of the disease. Diagnosing tumors at an early stage is challenging due to the absence or nonspecificity of symptoms and overall lack of specificity and sensitivity of diagnostic methods. Several improvements have been made in past decades, especially with emerging molecular diagnostic tools....
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#1Yikun Huang (UConn: University of Connecticut)H-Index: 5
#2André O'Reilly Beringhs (UConn: University of Connecticut)H-Index: 5
Last. Yu Lei (UConn: University of Connecticut)H-Index: 41
view all 9 authors...
Outer membrane vesicles (OMVs) produced by Gram-negative bacteria play significant roles in the biomedical field as they can be facilely functionalized using genetic engineering tools and thus often serve as a versatile multifunctional nanoparticles for a variety of applications. In this study, we investigated the multifaceted bioluminescence kinetics of a NanoLuc luciferase-expressed outer membrane vesicle produced by E. coli. This multifunctional OMV emits strong blue luminescence at 460 nm af...
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#1Brenda De Espíndola (UFSC: Universidade Federal de Santa Catarina)H-Index: 1
#2André O'Reilly Beringhs (UConn: University of Connecticut)H-Index: 5
Last. Bianca Ramos Pezzini (UFSC: Universidade Federal de Santa Catarina)H-Index: 6
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Abstract Liquisolid pellets (LPs) prepared by extrusion-spheronization are promising delivery systems to improve the dissolution rate of poorly water-soluble drugs. However, developing LPs for high dose drugs (e.g. antiretroviral ritonavir, RTV) is a major challenge due to technical and quality constraints. In this study, formulations LP1 and LP2 were obtained (RTV 100 mg/unit dose) using microcrystalline cellulose (carrier), Kollidon® CL-SF (coating and disintegrating material) and high load (3...
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#1Donghui SongH-Index: 9
Last. Xiuling LuH-Index: 16
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#1Maria Terezinha França (UFSC: Universidade Federal de Santa Catarina)H-Index: 4
#2André O'Reilly Beringhs (UFSC: Universidade Federal de Santa Catarina)H-Index: 5
Last. Hellen Karine Stulzer (UFSC: Universidade Federal de Santa Catarina)H-Index: 17
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Abstract Solid dispersions (SDs) of chlorthalidone (CTD) are promising systems to enhance drug dissolution rate, generate and maintain drug supersaturation levels in gastrointestinal fluids. In this work, SDs of CTD were prepared by spray drying using sodium alginate (SA) as carrier. Six formulations were prepared, varying the drug loading and composition, through the combination of SA with surfactants (sodium lauryl sulfate (SLS) or polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol gr...
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#1Rajesh Lakshmanan (UConn: University of Connecticut)H-Index: 6
#2Jacob Campbell (UConn: University of Connecticut)H-Index: 2
Last. Nilanjana Maulik (UConn: University of Connecticut)H-Index: 61
view all 9 authors...
Abstract The complete loss of dermal tissue due to ischemia is a serious challenge facing clinicians. Frequently, the failure of wound healing is due to ischemic conditions prevailing at the site of damaged tissue. Restoration of lost vasculature at the ischemic site can be achieved by supplementing proangiogenic stimuli through an engineered scaffold mimicking dermal extracellular matrix. Towards this objective, we have developed an electrospun scaffold loaded with the pro-angiogenic molecule r...
3 CitationsSource
#1Daiane Anzilaggo (UFSC: Universidade Federal de Santa Catarina)H-Index: 1
#2André O'Reilly Beringhs (UFSC: Universidade Federal de Santa Catarina)H-Index: 5
Last. Hellen Karine Stulzer (UFSC: Universidade Federal de Santa Catarina)H-Index: 17
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Abstract The drug in a solid dosage form must undergo dissolution before it is available for absorption from the gastrointestinal tract. Liquisolid system (LS) is a technology used for increasing aqueous solubility of the drugs, which has an important role in the dissolution and absorption phenomena. However, many factors can influence the performance and success of LS. Therefore this study aimed to evaluate through a factorial design, the factors such as drug state (solution or dispersion), non...
1 CitationsSource
#1Jun Chen (UConn: University of Connecticut)H-Index: 8
#2Qiuchen Dong (UConn: University of Connecticut)H-Index: 9
Last. Yu Lei (UConn: University of Connecticut)H-Index: 41
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1 CitationsSource
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