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Yiqin Wang
Shanghai Jiao Tong University
Downregulation and upregulationTraumatic brain injuryMethyltransferase complexAnesthesiaMedicine
4Publications
3H-index
39Citations
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Publications 4
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#1Yiqin Wang (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Xiaohui Liu (SJTU: Shanghai Jiao Tong University)H-Index: 4
Last. Jun Zhu (SJTU: Shanghai Jiao Tong University)H-Index: 24
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Abstract Hypoxia is widely considered as a limiting factor in vertebrate embryonic development, which requires adequate oxygen delivery for efficient energy metabolism, while nowadays some researches have revealed that hypoxia can induce stem cells so as to improve embryonic development. Erythroid differentiation is the oxygen delivery method employed by vertebrates at the very early step of embryo development, however, the mechanism how erythroid progenitor cell was triggered into mature erythr...
1 CitationsSource
#1Bao‐Shu Xie (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Yiqin Wang (SJTU: Shanghai Jiao Tong University)H-Index: 3
Last. JiangJi-yao (SJTU: Shanghai Jiao Tong University)H-Index: 2
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AIMS: Ferroptosis, a new form of iron-dependent programmed cell death, has been shown to be involved in a range of diseases. However, the role of ferroptosis in traumatic brain injury (TBI) has yet to be elucidated. We aimed to investigate whether ferroptosis is induced after TBI and whether the inhibition of ferroptosis would protect against traumatic brain injury in a controlled cortical impact injury (CCI) mouse model. METHODS: After establishing the TBI model in mice, we determined the bioch...
19 CitationsSource
#1Yiqin Wang (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Jian Mao (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Baoshu Xie (SYSU: Sun Yat-sen University)H-Index: 1
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: Aim: To systematically profile RNA m6A modification landscape after traumatic brain injury (TBI) in mice. Materials & methods: Expression of m6A-related genes was detected by quantitative real-time PCR (qPCR). Expression and location of METTL3, a key component of m6A methyltransferase complex, were determined by immunostaining. Genome-wide profiling of m6A-tagged transcripts was conducted by m6A-modified RNA immunoprecipitation sequencing (m6A-RIP-seq) and RNA sequencing (RNA-seq). Results: ME...
6 CitationsSource
#1Bao‐Shu Xie (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Yiqin Wang (SJTU: Shanghai Jiao Tong University)H-Index: 3
Last. JiangJi-yao (SJTU: Shanghai Jiao Tong University)H-Index: 2
view all 9 authors...
Circular RNAs (circRNAs) are involved in a variety of diseases. However, the roles of circRNAs in traumatic brain injury (TBI) remain unknown. In this study, circRNA microarray was used to profile the altered circRNAs in the rat hippocampus following TBI. A total of 192 circRNAs were observed to be differentially expressed (FC ≥1.5 and P <0.05) after TBI ,including 98 up-regulated and 94 down-regulated. Gene ontology (GO) and KEGG pathway analysis indicated that many mRNAs transcribed from the h...
13 CitationsSource
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