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Aline Benedita dos Santos Fonseca
Universidade Federal de Santa Catarina
NanoparticleFluidized bedFilm coatingPLGACoating
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Abstract A Quality by Design approach was taken to assess the influence of several formulation parameters on critical quality attributes of liquisolid pellets (LPs) obtained by extrusion-spheronization. Two mixture experimental designs were used, one for each of the non-volatile solvents (NVS) studied: Kolliphor® EL or PEG 400. The studied parameters were the concentrations of NVS (A-Kolliphor® EL, 0–40% w/w; or PEG 400, 0–31.1% w/w), coating material (B-crospovidone, 0–50.3% w/w) and carrier (C...
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#1André O'Reilly Beringhs (UFSC: Universidade Federal de Santa Catarina)H-Index: 5
#2Aline Benedita dos Santos Fonseca (UFSC: Universidade Federal de Santa Catarina)
Last. Diva Sonaglio (UFSC: Universidade Federal de Santa Catarina)H-Index: 7
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Micro- and nanoparticles have been vastly studied due to their biopharmaceutical advantages. However, these particles generally display very weak packing and poor mechanical properties. Hereby, a new methodology is proposed to associate poorly flowing particles to macrostructures targeting the improvement of flowability and redispersibility of the particles. Cecropia glaziovii-loaded PLGA microspheres (4.59 ± 0.04 μm) were associated with carrier pellets by film coating in a top-spray fluid bed ...
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