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M. Ibrahim Khot
St James's University Hospital
5Publications
2H-index
5Citations
Publications 6
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#1M. Ibrahim Khot (St James's University Hospital)H-Index: 2
#2Candice L. Downey (St James's University Hospital)H-Index: 6
Last.David Jayne (St James's University Hospital)H-Index: 40
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Abstract The ATP-binding cassette (ABC) superfamily G member 2 (ABCG2) transmembrane protein transporter is known for conferring resistance to treatment in cancers. Photodynamic therapy (PDT) is a promising anti-cancer method involving the use of light-activated photosensitisers to precisely induce oxidative stress and cell death in cancers. ABCG2 can efflux photosensitisers from out of cells, reducing the capacity of PDT and limiting the efficacy of treatment. Many studies have attempted to elu...
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#1M. Ibrahim Khot (St James's University Hospital)H-Index: 2
#2Helen Andrew (St James's University Hospital)H-Index: 2
Last.David Jayne (St James's University Hospital)H-Index: 40
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Abstract Oncologic thermal ablation involves the use of hyperthermic temperatures to damage and treat solid cancers. Thermal ablation is being investigated as a method of treatment in colorectal cancers and has the potential to complement conventional anticancer treatments in managing local recurrence and metastatic disease. Photothermal therapy utilizes photosensitive agents to generate local heat and induce thermal ablation. There is growing interest in developing nanotechnology platforms to d...
3 CitationsSource
#1M. Ibrahim Khot (St James's University Hospital)H-Index: 2
#2Mark A. Levenstein (University of Leeds)H-Index: 4
Last.David Jayne (St James's University Hospital)H-Index: 40
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Introduction: Three-dimensional (3D) cell cultures are identified as more accurate and representative models of human cancers than conventional two-dimensional monolayer cell cultures. However, currently established 3D culturing techniques are technically challenging, time- and resource-consuming, and performed using traditional laboratory tissue culturing equipment. In recent years, microfluidics has been introduced into biomedical research, allowing cells and tissues to be cultured in microfab...
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#1M. Ibrahim Khot (St James's University Hospital)H-Index: 2
#2Sl Perry (St James's University Hospital)H-Index: 15
Last.David Jayne (St James's University Hospital)H-Index: 40
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Abstract Background Photodynamic Therapy (PDT) is an attractive modality for treating solid cancers. This study evaluates the efficacy of Hypericin-PDT as a cytotoxic therapy in colorectal cancer (CRC), using 2D cell cultures and 3D multicellular tumour spheroids. Methods Spheroids were generated through forced-floating and agitation-based techniques. 2D and spheroid models of HT29 and HCT116 CRC cells were incubated with Hypericin (0–200 nM) for 16 h. Cultures were irradiated with light (1 J/cm...
2 CitationsSource
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