Buczko W
Medical University of Białystok
Publications 20
#1Karol Kramkowski (UMB: Medical University of Białystok)H-Index: 13
#2Agnieszka Leszczynska (UMB: Medical University of Białystok)H-Index: 7
Last.Stefan Chlopicki (Jagiellonian University Medical College)H-Index: 29
view all 12 authors...
AbstractThe mechanisms underlying nitrite-induced effects on thrombosis and hemostasis in vivo are not clear. The goal of the work described here was to investigate the role of xanthine oxidoreductase (XOR) in the anti-platelet and anti-thrombotic activities of nitrite in rats in vivo. Arterial thrombosis was induced electrically in rats with renovascular hypertension by partial ligation of the left renal artery. Sodium nitrite (NaNO2, 0.17 mmol/kg twice daily for 3 days, p.o) was administered w...
6 CitationsSource
#1Andrzej Mogielnicki (UMB: Medical University of Białystok)H-Index: 15
#2Karol Kramkowski (UMB: Medical University of Białystok)H-Index: 13
Last.Buczko WH-Index: 12
view all 6 authors...
Introduction:ACE2 alternatively converts angiotensin (Ang) II into Ang-(1–7) and Ang I into Ang-(1–9). There is little information in the literature with respect to Ang-(1–9) properties. A number of studies show a link between peptides of the renin-angiotensin system and thrombosis.Materials and methods:We have investigated the influence of Ang-(1–9) on stasis-induced venous thrombosis in the rat. The contribution of coagulation and fibrinolytic systems, angiotensin receptor type 1 (AT1) and MAS...
9 CitationsSource
#1Karol Kramkowski (UMB: Medical University of Białystok)H-Index: 13
#2Andrzej MogielnickiH-Index: 15
Last.Buczko WH-Index: 12
view all 4 authors...
Angiotensin (Ang) (1-9) is the renin-angiotensin-system peptide found in the plasma of healthy volunteers and after angiotensin-converting-enzyme inhibitors therapy. In vitro experiments proved that Ang-(1-9) may be produced from Ang I. In our study, we tried to expand the poor data about the in vivo properties of Ang-(1-9). We revealed that Ang-(1-9) enhanced electrically stimulated arterial thrombosis in the carotid artery of Wistar rats. Losartan, a selective blocker of AT, receptor for Ang I...
22 Citations
#1L. PietrzakH-Index: 2
#2Andrzej MogielnickiH-Index: 15
Last.Buczko WH-Index: 12
view all 3 authors...
Summary Background. It has been suggested that topically applied nicotinamide and its metabolite N-methylnicotinamide (NMN+) might be useful agents for treatment of dermatological disorders such as acne vulgaris and rosacea. Aim. This study aimed to find out if the mechanism of these therapeutic effects depends on their vascular effects, by investigating if nicotinamide and NMN+ are able to influence vascular permeability of the vessels in the skin on the back of Wistar rats. Methods and results...
14 CitationsSource
Background: So far studies showing the role of the plasmin system in airway remodelling have been conducted using in vitro models. The aim of the present study was to determine plas
8 CitationsSource
#1Andrzej MogielnickiH-Index: 15
#2Karol KramkowskiH-Index: 13
Last.Buczko WH-Index: 12
view all 4 authors...
N-methylnicotinamide, a nicotinamide derivative, possesses anti-thrombotic activity, although the mechanism of its action is unclear. Using a rat model of isolated perfused hindlimb, we tested whether this metabolite of nicotinamide is able to inhibit the vasoconstrictive effects of epinephrine, norepinephrine, and angiotensin II, thereby releasing prostacyclin from the endothelium. We found that N-methylnicotinamide administration by infusion or bolus injection did not change the course of perf...
4 Citations
#1Stefan Chlopicki (Jagiellonian University Medical College)H-Index: 29
#2J Swies (Jagiellonian University Medical College)H-Index: 1
Last.Jerzy Gebicki (University of Łódź)H-Index: 15
view all 8 authors...
Background and purpose: 1-methylnicotinamide (MNA) has been considered to be an inactive metabolite of nicotinamide. Here we assessed the anti-thrombotic activity of MNA in vivo. Experimental approach: Antithrombotic action of MNA was studied in normotensive rats with extracorporeal thrombus formation (thrombolysis), in renovascular hypertensive rats with intraarterial thrombus formation (arterial thrombosis) and in a venous thrombosis model in rats (venous thrombosis). Key results: MNA (3-100 m...
119 CitationsSource
There are few findings indicating that nicotinamide may potentially influence intravascular thrombosis. Interestingly, N-methylnicotinamide, one of the metabolites of nicotinamide - could be more potent than its parent compound. In the present study we have investigated the influence ofN-methylnicotinamide on arterial thrombosis in normotensive and renovascular hypertensive rats. The contribution of platelets, coagulation and fibrinolytic systems in the mode of N-methylnicotinamide action was al...
26 Citations
#1Buczko WH-Index: 12
#2Karol KramkowskiH-Index: 13
Last.Andrzej MogielnickiH-Index: 15
view all 3 authors...
The endothelial mechanism of ACE-Is action is multifaceted. On the one hand, by inhibiting ACE, ACE-Is diminish Ang II synthesis, one of the best known active peptides. On the other hand, they modify synthesis and release of PGI and NO via increasing production of other biologically important peptides like bradykinin, Ang-(1-7) or Ang-(1-9). Thus, ACE-Is play a crucial role in the function of endothelium and are effective and important tool for therapy of range of cardiovascular system disorders...
14 Citations
This study compared the antihrombotic effect of plasma angiotensin converting enzyme inhibitors (ACE-Is): captopril (CAP), enalapril (ENA) and tissue ACE-Is: perindopril (PER), quinapril (QUIN) in experimental venous and arterial thrombosis. Normotensive Wistar rats were treated p.o. with CAP (75 mg/kg), ENA (20 mg/kg), PER (2 mg/kg) and QUIN (3 mg/kg) for 10 days. The influence of ACE-Is on coagulation and fibrinolytic systems as well as platelet function was evaluated. The hypotensive effect o...
21 Citations