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Buczko W
Medical University of Białystok
13Publications
11H-index
381Citations
Publications 13
Newest
Published on Apr 2, 2016in Platelets 3.11
Karol Kramkowski12
Estimated H-index: 12
(UMB: Medical University of Białystok),
Agnieszka Leszczynska7
Estimated H-index: 7
(UMB: Medical University of Białystok)
+ 9 AuthorsEwa Chabielska16
Estimated H-index: 16
(UMB: Medical University of Białystok)
AbstractThe mechanisms underlying nitrite-induced effects on thrombosis and hemostasis in vivo are not clear. The goal of the work described here was to investigate the role of xanthine oxidoreductase (XOR) in the anti-platelet and anti-thrombotic activities of nitrite in rats in vivo. Arterial thrombosis was induced electrically in rats with renovascular hypertension by partial ligation of the left renal artery. Sodium nitrite (NaNO2, 0.17 mmol/kg twice daily for 3 days, p.o) was administered w...
Andrzej Mogielnicki14
Estimated H-index: 14
(UMB: Medical University of Białystok),
Karol Kramkowski12
Estimated H-index: 12
(UMB: Medical University of Białystok)
+ 3 AuthorsWlodzimierz Buczko22
Estimated H-index: 22
Introduction:ACE2 alternatively converts angiotensin (Ang) II into Ang-(1–7) and Ang I into Ang-(1–9). There is little information in the literature with respect to Ang-(1–9) properties. A number of studies show a link between peptides of the renin-angiotensin system and thrombosis.Materials and methods:We have investigated the influence of Ang-(1–9) on stasis-induced venous thrombosis in the rat. The contribution of coagulation and fibrinolytic systems, angiotensin receptor type 1 (AT1) and MAS...
Published on Jan 1, 2010in Journal of Physiology and Pharmacology 2.54
Karol Kramkowski12
Estimated H-index: 12
(UMB: Medical University of Białystok),
Andrzej Mogielnicki14
Estimated H-index: 14
+ 1 AuthorsBuczko W11
Estimated H-index: 11
Angiotensin (Ang) (1-9) is the renin-angiotensin-system peptide found in the plasma of healthy volunteers and after angiotensin-converting-enzyme inhibitors therapy. In vitro experiments proved that Ang-(1-9) may be produced from Ang I. In our study, we tried to expand the poor data about the in vivo properties of Ang-(1-9). We revealed that Ang-(1-9) enhanced electrically stimulated arterial thrombosis in the carotid artery of Wistar rats. Losartan, a selective blocker of AT, receptor for Ang I...
Published on Apr 1, 2009in Clinical and Experimental Dermatology 1.77
L. Pietrzak2
Estimated H-index: 2
,
Andrzej Mogielnicki14
Estimated H-index: 14
,
Buczko W11
Estimated H-index: 11
Summary Background. It has been suggested that topically applied nicotinamide and its metabolite N-methylnicotinamide (NMN+) might be useful agents for treatment of dermatological disorders such as acne vulgaris and rosacea. Aim. This study aimed to find out if the mechanism of these therapeutic effects depends on their vascular effects, by investigating if nicotinamide and NMN+ are able to influence vascular permeability of the vessels in the skin on the back of Wistar rats. Methods and results...
Published on Jan 1, 2008in International Archives of Allergy and Immunology 2.93
Kucharewicz I13
Estimated H-index: 13
,
Andrzej Mogielnicki14
Estimated H-index: 14
+ 2 AuthorsAnna Bodzenta-Łukaszyk8
Estimated H-index: 8
Background: So far studies showing the role of the plasmin system in airway remodelling have been conducted using in vitro models. The aim of the present study was to determine plas
Published on Jan 1, 2008in Pharmacological Reports 2.76
Andrzej Mogielnicki14
Estimated H-index: 14
,
Karol Kramkowski12
Estimated H-index: 12
+ 1 AuthorsBuczko W11
Estimated H-index: 11
N-methylnicotinamide, a nicotinamide derivative, possesses anti-thrombotic activity, although the mechanism of its action is unclear. Using a rat model of isolated perfused hindlimb, we tested whether this metabolite of nicotinamide is able to inhibit the vasoconstrictive effects of epinephrine, norepinephrine, and angiotensin II, thereby releasing prostacyclin from the endothelium. We found that N-methylnicotinamide administration by infusion or bolus injection did not change the course of perf...
Published on Sep 1, 2007in British Journal of Pharmacology 6.58
Stefan Chlopicki27
Estimated H-index: 27
(Jagiellonian University Medical College),
J Swies1
Estimated H-index: 1
(Jagiellonian University Medical College)
+ 5 AuthorsJerzy Gebicki15
Estimated H-index: 15
(University of Łódź)
Background and purpose: 1-methylnicotinamide (MNA) has been considered to be an inactive metabolite of nicotinamide. Here we assessed the anti-thrombotic activity of MNA in vivo. Experimental approach: Antithrombotic action of MNA was studied in normotensive rats with extracorporeal thrombus formation (thrombolysis), in renovascular hypertensive rats with intraarterial thrombus formation (arterial thrombosis) and in a venous thrombosis model in rats (venous thrombosis). Key results: MNA (3-100 m...
Published on Jan 1, 2007in Journal of Physiology and Pharmacology 2.54
Andrzej Mogielnicki14
Estimated H-index: 14
,
Karol Kramkowski12
Estimated H-index: 12
+ 1 AuthorsBuczko W11
Estimated H-index: 11
There are few findings indicating that nicotinamide may potentially influence intravascular thrombosis. Interestingly, N-methylnicotinamide, one of the metabolites of nicotinamide - could be more potent than its parent compound. In the present study we have investigated the influence ofN-methylnicotinamide on arterial thrombosis in normotensive and renovascular hypertensive rats. The contribution of platelets, coagulation and fibrinolytic systems in the mode of N-methylnicotinamide action was al...
Published on Jan 1, 2006in Pharmacological Reports 2.76
Buczko W11
Estimated H-index: 11
,
Karol Kramkowski12
Estimated H-index: 12
,
Andrzej Mogielnicki14
Estimated H-index: 14
The endothelial mechanism of ACE-Is action is multifaceted. On the one hand, by inhibiting ACE, ACE-Is diminish Ang II synthesis, one of the best known active peptides. On the other hand, they modify synthesis and release of PGI and NO via increasing production of other biologically important peptides like bradykinin, Ang-(1-7) or Ang-(1-9). Thus, ACE-Is play a crucial role in the function of endothelium and are effective and important tool for therapy of range of cardiovascular system disorders...
Published on Jan 1, 2006in Journal of Physiology and Pharmacology 2.54
Marzena Wojewodzka-Zelezniakowicz5
Estimated H-index: 5
,
Ewa Chabielska16
Estimated H-index: 16
+ 6 AuthorsBuczko W11
Estimated H-index: 11
This study compared the antihrombotic effect of plasma angiotensin converting enzyme inhibitors (ACE-Is): captopril (CAP), enalapril (ENA) and tissue ACE-Is: perindopril (PER), quinapril (QUIN) in experimental venous and arterial thrombosis. Normotensive Wistar rats were treated p.o. with CAP (75 mg/kg), ENA (20 mg/kg), PER (2 mg/kg) and QUIN (3 mg/kg) for 10 days. The influence of ACE-Is on coagulation and fibrinolytic systems as well as platelet function was evaluated. The hypotensive effect o...
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