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Jonathan Pol
McMaster University
47Publications
16H-index
1,005Citations
Publications 47
Newest
#1Jonathan PolH-Index: 16
#2Byram W. Bridle (U of G: University of Guelph)H-Index: 16
Last.Brian D. Lichty (McMaster University)H-Index: 37
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#1Peng Liu (Sorbonne)H-Index: 38
#2Liwei Zhao (Sorbonne)H-Index: 5
Last.Guido KroemerH-Index: 197
view all 34 authors...
Immunogenic cell death (ICD) converts dying cancer cells into a therapeutic vaccine and stimulates antitumor immune responses. Here we unravel the results of an unbiased screen identifying high-dose (10 µM) crizotinib as an ICD-inducing tyrosine kinase inhibitor that has exceptional antineoplastic activity when combined with non-ICD inducing chemotherapeutics like cisplatin. The combination of cisplatin and high-dose crizotinib induces ICD in non-small cell lung carcinoma (NSCLC) cells and effec...
10 CitationsSource
#1Peng LiuH-Index: 38
#2Liwei ZhaoH-Index: 5
Last.Guido KroemerH-Index: 197
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The original version of this Article contained an error in the spelling of the author Lin Xia, which was incorrectly given as Xia Lin. This has now been corrected in both the PDF and HTML versions of the Article.
Source
#1Sarah Lévesque (University of Paris-Sud)
#2Julie Le Naour (University of Paris-Sud)
Last.Jonathan PolH-Index: 16
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ABSTRACTWe have recently shown that chemotherapy with immunogenic cell death (ICD)-inducing agents can be advantageously combined with fasting regimens or caloric restriction mimetics (CRMs) to ach...
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#1Jonathan PolH-Index: 16
#2Pamela Caudana (French Institute of Health and Medical Research)
Last.Guido KroemerH-Index: 197
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#1José Manuel Bravo-San Pedro (University of Paris)H-Index: 1
#2Valentina Sica (University of Paris)H-Index: 11
Last.Guido KroemerH-Index: 197
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Summary Autophagy facilitates the adaptation to nutritional stress. Here, we show that short-term starvation of cultured cells or mice caused the autophagy-dependent cellular release of acyl-CoA-binding protein (ACBP, also known as diazepam-binding inhibitor, DBI) and consequent ACBP-mediated feedback inhibition of autophagy. Importantly, ACBP levels were elevated in obese patients and reduced in anorexia nervosa. In mice, systemic injection of ACBP protein inhibited autophagy, induced lipogenes...
3 CitationsSource
#2Valeria D’ArgenioH-Index: 13
Last.F. SalvatoreH-Index: 85
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Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different subtypes that differ in their clinical and prognostic features. In the past decade, in addition to the conventional adenoma-carcinoma model, an alternative multistep mechanism of carcinogenesis, namely the “serrated pathway”, has been described. Approximately, 15 to 30% of all CRCs arise from neoplastic serrated polyps, a heterogeneous group of lesions that are histologically classified into three morphol...
1 CitationsSource
#1Wei XieH-Index: 2
#2Laura MondragónH-Index: 10
Last.Guido KroemerH-Index: 197
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ABSTRACTLocal immunotherapies such as the intratumoral injection of oncolytic compounds aim at reinstating and enhancing systemic anticancer immune responses. LTX-315 is a first-in-class, clinicall...
1 CitationsSource
#1Sarah LevesqueH-Index: 6
#2Jonathan PolH-Index: 16
Last.Guido Kroemer (UPMC: Pierre-and-Marie-Curie University)H-Index: 197
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ABSTRACTDietary interventions have a profound impact on whole body metabolism, including oncometabolism (the metabolic features allowing cancer cells to proliferate) and immunometabolism (the catabolic and anabolic reactions that regulate immune responses). Recent preclinical studies demonstrated that multiple dietary changes can improve anticancer immunosurveillance of chemo-, radio- and immunotherapy. These findings have fostered the design of clinical trials evaluating the capacity of dietary...
2 CitationsSource
#1Valentina Sica (Paris V: Paris Descartes University)H-Index: 11
#2José Manuel Bravo-San Pedro (Paris V: Paris Descartes University)H-Index: 27
Last.Maria Chiara Maiuri (Paris V: Paris Descartes University)H-Index: 48
view all 23 authors...
Summary Inhibition of oxidative phosphorylation (OXPHOS) by 1-cyclopropyl-4-(4-[(5-methyl-3-(3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl]pyridin-2-yl)piperazine (BAY87-2243, abbreviated as B87), a complex I inhibitor, fails to kill human cancer cells in vitro . Driven by this consideration, we attempted to identify agents that engage in synthetically lethal interactions with B87. Here, we report that dimethyl α-ketoglutarate (DMKG), a cell-permeable precursor of α...
2 CitationsSource
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