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Youhe Gao
Beijing Normal University
42Publications
7H-index
162Citations
Publications 44
Newest
#1Ting Wang (BNU: Beijing Normal University)H-Index: 2
#2Lujun Li (BNU: Beijing Normal University)H-Index: 1
Last.Youhe Gao (BNU: Beijing Normal University)H-Index: 7
view all 4 authors...
Abstract In this study, Walker 256 cells were implanted into rat tibiae. Urine samples were then collected on days 3, 5, 7, and 13 and were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). With label-free quantification, 25 proteins were found to change significantly in the urine of the tumor group rats compared with the proteins in the urine of the control group rats; this was even the case when there were no significant lesions identified in the Computed Tomography (CT) e...
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#1Yongtao Liu (BNU: Beijing Normal University)H-Index: 1
#2Youzhu WangH-Index: 1
Last.Youhe Gao (BNU: Beijing Normal University)H-Index: 7
view all 4 authors...
In this report, the urinary proteome from a patient-derived xenograft (PDX) model was examined at the peptide level to study the origins of urinary proteins in tumor-bearing nude mice. Urine was collected from PDX mice before and after colorectal tumor implantation. A total of 4318 unique peptides were identified, and 78 unambiguous human-origin peptides were discerned in the PDX model urine. Unlike the differential urinary protein composition of tumor-bearing immunocompetent rat models, the dif...
2 CitationsSource
#1Jing Wei (BNU: Beijing Normal University)H-Index: 3
#2Na Ni (CQMU: Chongqing Medical University)H-Index: 1
Last.Youhe Gao (BNU: Beijing Normal University)H-Index: 7
view all 4 authors...
Detection of cancer at its early stage is important for treatment. Urine, which is not regulated by homeostatic mechanisms, reflects early systemic changes throughout the whole body and can be used for the early detection of cancer. In this study, the Walker-256 tail-vein injection rat model was established to find whether the urine proteome could reflect early changes if tumor grown in lung. Urine samples from the control group (n = 7) and Walker-256 tail-vein injection group (n = 7) on days 2,...
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#1Weiwei QinH-Index: 1
#2Lujun Li (BNU: Beijing Normal University)H-Index: 1
Last.Youhe Gao (BNU: Beijing Normal University)H-Index: 7
view all 3 authors...
Uveitis, a group of intraocular inflammatory diseases, is one of the major causes of severe visual impairment among working age population. Urine is a promising resource for biomarker research, which could sensitively reflect the changes of the body. This study was designed to explore urinary protein biomarkers for diagnosis and/or monitoring of uveitis. Experimental autoimmune uveitis (EAU) rat model induced by bovine interphotoreceptor retinoid-binding protein (IRBP) was used to mimic the uvei...
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#1Jing Wei (BNU: Beijing Normal University)H-Index: 3
#2Wenshu Meng (BNU: Beijing Normal University)
Last.Youhe Gao (BNU: Beijing Normal University)H-Index: 7
view all 3 authors...
Background Biomarkers are changes associated with the disease. Urine is not subject to homeostatic control and therefore accumulates very early changes, making it an ideal biomarker source. Usually, we have performed urinary biomarker studies involving at least thousands of tumor cells. However, no tumor starts from a thousand tumor cells. We therefore examined urine proteome changes in rats subcutaneously inoculated with approximately ten tumor cells.
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#1Weiwei Qin (BNU: Beijing Normal University)H-Index: 1
#2Weiwei QinH-Index: 1
Last.Youhe GaoH-Index: 7
view all 5 authors...
3 CitationsSource
#1Youhe Gao (BNU: Beijing Normal University)H-Index: 7
Source
#1Fanshuang Zhang (Peking Union Medical College)H-Index: 2
#2Xundou Li (Peking Union Medical College)H-Index: 6
Last.Youhe Gao (BNU: Beijing Normal University)H-Index: 7
view all 5 authors...
Biomarkers indicate changes associated with disease. Blood is relatively stable due to the homeostatic mechanisms of the body; however, urine accumulates metabolites from changes in the body, making it a better source for early biomarker discovery. The Li ethnic group is a unique minority ethnic group that has only lived on Hainan Island for approximately 5,000 years. Studies have shown that various specific genetic variations are different between the Li and Han ethnic groups. However, whether ...
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#1Ting Wang (BNU: Beijing Normal University)H-Index: 2
#2Lujun Li (BNU: Beijing Normal University)H-Index: 1
Last.Youhe Gao (BNU: Beijing Normal University)H-Index: 7
view all 5 authors...
In this study, Walker 256 cells were implanted into rat tibiae. Urine samples were then collected on days 3, 5, 7, and 13 and were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). With label-free quantification, 25 proteins were found to change significantly in the urine of the tumor group mice compared with the proteins in the urine of the control group mice; this was even the case when there were no significant lesions identified in the Computed Tomography(CT) examination...
1 CitationsSource
#1Yuqiu Li (BNU: Beijing Normal University)H-Index: 2
#2Linpei Zhang (BNU: Beijing Normal University)H-Index: 3
Last.Youhe Gao (BNU: Beijing Normal University)H-Index: 7
view all 4 authors...
Ovarian cancer is the most lethal gynecological malignancy in women, and it is likely to metastasize and has a poor prognosis. The early and reliable diagnosis and monitoring of ovarian cancer is very important. Without a homeostasis mechanism, urine can reflect early systemic changes in the body and has a great potential to be used for the early detection of cancer. This study tested whether early changes could be detected in two ovarian cancer rat models. Two rat models were established by eit...
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