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Youhe Gao
Beijing Normal University
17Publications
3H-index
36Citations
Publications 17
Newest
Published on Mar 21, 2019in Scientific Reports 4.01
Yongtao Liu1
Estimated H-index: 1
(BNU: Beijing Normal University),
Youzhu Wang1
Estimated H-index: 1
+ 1 AuthorsYouhe Gao3
Estimated H-index: 3
(BNU: Beijing Normal University)
In this report, the urinary proteome from a patient-derived xenograft (PDX) model was examined at the peptide level to study the origins of urinary proteins in tumor-bearing nude mice. Urine was collected from PDX mice before and after colorectal tumor implantation. A total of 4,318 unique peptides were identified, and 78 unambiguous human-origin peptides were discerned in the PDX model urine. Unlike the differential urinary protein composition of tumor-bearing immunocompetent rat models, the di...
Published on May 20, 2019in Science China-life Sciences 3.58
Youhe Gao3
Estimated H-index: 3
(BNU: Beijing Normal University),
Youhe Gao
Published in Cancer Medicine 3.36
Linpei Zhang1
Estimated H-index: 1
(BNU: Beijing Normal University),
Yuqiu Li1
Estimated H-index: 1
(BNU: Beijing Normal University)
+ -3 AuthorsYouhe Gao3
Estimated H-index: 3
(BNU: Beijing Normal University)
Published on Apr 18, 2019in bioRxiv
Ting Wang1
Estimated H-index: 1
(BNU: Beijing Normal University),
Lujun Li (BNU: Beijing Normal University)+ 2 AuthorsYouhe Gao1
Estimated H-index: 1
(BNU: Beijing Normal University)
In this study, Walker 256 cells were implanted into rat tibiae. Urine samples were then collected on days 3, 5, 7, and 13 and were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). With label-free quantification, 25 proteins were found to change significantly in the urine of the tumor group mice compared with the proteins in the urine of the control group mice; this was even the case when there were no significant lesions identified in the Computed Tomography(CT) examination...
Published on Apr 10, 2019in bioRxiv
Jing Wei1
Estimated H-index: 1
(BNU: Beijing Normal University),
Wenshu Meng (BNU: Beijing Normal University)+ 0 AuthorsYouhe Gao1
Estimated H-index: 1
(BNU: Beijing Normal University)
Biomarkers are changes associated with the disease. Without homeostatic control, urine accumulates very early changes and is an ideal biomarker source. Usually, we performed urinary biomarker studies involving at least thousands of tumor cells. But no tumor starts from a thousand tumor cells. Can we observe any urine proteome changes in rats with approximately ten tumor cells subcutaneous inoculation? Here, we serially diluted Walker-256 carcinosarcoma cells to a concentration of 102/mL and subc...
Published on Apr 10, 2019in bioRxiv
Yuqiu Li1
Estimated H-index: 1
(BNU: Beijing Normal University),
Linpei Zhang1
Estimated H-index: 1
(BNU: Beijing Normal University)
+ 1 AuthorsYouhe Gao1
Estimated H-index: 1
(BNU: Beijing Normal University)
Ovarian cancer is the most lethal gynecological malignancy in women, and it is likely to metastasize and has a poor prognosis. The early and reliable diagnosis and monitoring of ovarian cancer is very important. Without a homeostasis mechanism, urine can reflect early systemic changes in the body and has a great potential to be used for the early detection of cancer. This study tested whether early changes could be detected in two ovarian cancer rat models. Two rat models were established by eit...
Published on Feb 22, 2019in Science China-life Sciences 3.58
Weiwei Qin (BNU: Beijing Normal University), Ting Wang1
Estimated H-index: 1
(BNU: Beijing Normal University)
+ 1 AuthorsYouhe Gao3
Estimated H-index: 3
(BNU: Beijing Normal University)
A biomarker is a measurable indicator associated with changes in physiological state or disease. In contrast to the blood which is under homeostatic controls, urine reflects changes in the body earlier and more sensitively, and is therefore a better biomarker source. Lysine acetylation is an abundant and highly regulated post-translational modification. It plays a pivotal role in modulating diverse biological processes and is associated with various important diseases. Enrichment or visualizatio...
Published on Jan 13, 2019in bioRxiv
Jing Wei1
Estimated H-index: 1
(BNU: Beijing Normal University),
Na Ni1
Estimated H-index: 1
(CQMU: Chongqing Medical University)
+ 2 AuthorsYouhe Gao1
Estimated H-index: 1
(BNU: Beijing Normal University)
The early detection of cancer is essential for effective intervention. Urine, which lacks homeostatic control, has been used to reflect early systemic changes in subcutaneous cancer models. However, urine has not been used to predict whether tumors will be formed in animal models. In this study, a cancer model was established by the tail-vein injection of 2 million NuTu-19 tumor cells. Approximately half of the rats formed lung metastatic carcinoma tumors. Urine samples were randomly selected fr...
Published on Jan 4, 2019in bioRxiv
Yongtao Liu1
Estimated H-index: 1
(BNU: Beijing Normal University),
Yutong Hou (BNU: Beijing Normal University)+ 1 AuthorsYouhe Gao1
Estimated H-index: 1
(BNU: Beijing Normal University)
Biomarkers are measurable changes associated with disease. Exhaled breath provides many signs of bodily changes and has been proposed to be a good early biomarker source because it lacks homeostatic mechanisms. Earlier biomarker detection can provide earlier diagnosis, which can bring about more choices and more time for treatment. The benefit of studying exhaled breath in animal models is that most interfering factors can be avoided, and earlier changes in disease may be found. However, there i...
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