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Bian Hu
National Resource Center
3Publications
1H-index
4Citations
Publications 3
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#1Bian HuH-Index: 1
#2Yan ZouH-Index: 1
Last.Xuekai ZhuH-Index: 1
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CRISPR/Cas9-mediated programmed cell death protein 1 (PD-1) disruption in chimeric antigen receptor (CAR) T cells could be an appealing choice to improve the therapeutic efficacy of CAR T cells in ...
Source
#1Bian Hu (National Resource Center)H-Index: 1
#2Yan Zou (ShanghaiTech University)H-Index: 1
Last.Xuekai Zhu (ShanghaiTech University)H-Index: 1
view all 8 authors...
CRISPR/Cas9-mediated programmed cell death protein 1 (PD-1) disruption in chimeric antigen receptor (CAR) T cells could be an appealing choice to improve the therapeutic efficacy of CAR T cells in an immunosuppressive tumor microenvironment. In most of the reported cases, Cas9 was delivered into T cells by way of electroporation with RNA or protein. However, transient expression of Cas9 by transfection with a plasmid encoding its gene is apparently simpler, as it avoids the steps of in vitro tra...
4 CitationsSource
#1Bian HuH-Index: 1
#2Yan ZouH-Index: 1
Last.Xuekai ZhuH-Index: 1
view all 8 authors...
CRISPR/Cas9-mediated PD-1 disruption in chimeric antigen receptor (CAR) T cells could be an appealing choice to improve the therapeutic efficacy of CAR T cells in an immunosuppressive tumor microenvironment. In most of the reported cases, Cas9 was delivered into T cells by way of electroporation with RNA or protein. However, transient expression of Cas9 by transfection with a plasmid encoding its gene is apparently simpler, as it avoids the steps of in vitro transcription of DNA or protein produ...
Source
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