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Young Youn Cho
Seoul National University
Hazard ratioHepatitis BHepatocellular carcinomaMedicineGastroenterology
51Publications
9H-index
270Citations
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Publications 56
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#1Young Youn Cho (CAU: Chung-Ang University)H-Index: 9
#2Su Jong YuH-Index: 21
Last. Jung-Hwan YoonH-Index: 44
view all 11 authors...
Background/Aims:Transarterial chemoembolization (TACE) is a major therapeutic modality for patients with unresectable hepatocellular carcinoma, which needs repeated treatments. Model to Estimate Survival in Ambulatory Hepatocellular carcinoma patients (MESIAH) was recently developed as a model for p
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#1Young Youn Cho (CAU: Chung-Ang University)H-Index: 9
#2Young Jun Chang (SNU: Seoul National University)H-Index: 21
Last. Yoon Jun Kim (SNU: Seoul National University)H-Index: 37
view all 9 authors...
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#1Sang Lim Choi (CAU: Chung-Ang University)
#2Eun Sun Lee (CAU: Chung-Ang University)H-Index: 14
Last. Stephan Kannengiesser (Siemens)H-Index: 17
view all 8 authors...
Objectives To determine the technical success rates of MR elastography (MRE) according to established gradient-recalled echo (GRE) and spin-echo echo-planar imaging (SE-EPI) sequences and to compare liver stiffness (LS) values between the sequences during expiratory and inspiratory phases in patients with chronic liver disease or liver cirrhosis.
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#1Young Youn Cho (SNU: Seoul National University)H-Index: 9
#2Young Hwan Choi (CAU: Chung-Ang University)H-Index: 3
Last. Jung-Hwan Yoon (SNU: Seoul National University)H-Index: 44
view all 7 authors...
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#1Yun Bin Lee (SNU: Seoul National University)H-Index: 8
#2Joon Yeul Nam (SNU: Seoul National University)H-Index: 4
Last. Jung-Hwan Yoon (SNU: Seoul National University)H-Index: 44
view all 14 authors...
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#1Hyeki ChoH-Index: 7
#2Young Jun ChangH-Index: 21
Last. Jung-Hwan YoonH-Index: 44
view all 12 authors...
Background and Goals:Although nonalcoholic fatty liver disease (NAFLD) is a risk factor of hepatocellular carcinoma (HCC), it is unclear whether NAFLD additionally increases the risk of HCC among chronic hepatitis B (CHB) patients. This study evaluated the association between NAFLD and the risk of H
1 CitationsSource
#1Deok gyun You (KU: Korea University)H-Index: 2
#2Young Youn Cho (SNU: Seoul National University)H-Index: 9
Last. Gi Young Lee (KU: Korea University)H-Index: 3
view all 9 authors...
Abstract Hepatitis B virus X protein (HBx) functions in a variety of cellular events during the HBV life cycle. In a previous study, we reported that the HBx protein is sufficient to induce mitochondrial membrane permeabilization; however, the exact mechanism of HBx-induced mitochondrial membrane permeabilization has been not proposed. In this study, we report that HBx specifically targets cardiolipin (CL) and induces membrane permeabilization depending on CL concentration in mitochondrial outer...
2 CitationsSource
#1Jeong Ju Yoo (SCH: Soonchunhyang University)H-Index: 8
#2Su Jong YuH-Index: 21
Last. Jung-Hwan YoonH-Index: 44
view all 11 authors...
This study aimed to examine whether inhibition of hexokinase (HK)-II activity enhances the efficacy of sorafenib in in-vivo models of hepatocellular carcinoma (HCC), and to evaluate the prognostic implication of HK-II expression in patients with HCC. We used 3-bromopyruvate (3-BP), a HK-II inhibitor to target HK-II. The human HCC cell line was tested as both subcutaneous and orthotopic tumor xenograft models in BALB/c nu/nu mice. The prognostic role of HK-II was evaluated in data from HCC patien...
3 CitationsSource
#1Eun Ju Cho (SNU: Seoul National University)H-Index: 16
#2Su Jong Yu (SNU: Seoul National University)H-Index: 21
Last. Jung-Hwan Yoon (SNU: Seoul National University)H-Index: 44
view all 10 authors...
Hypoxic conditions, which large or infiltrative hypovascular tumors may encounter, also produce acidic environments. Carbonic anhydrase-IX (CA-IX), an enzyme involved in lowering pH, is overexpressed in hepatocellular carcinoma (HCC). In the present study, whether inhibition of CA-IX enhances the efficacy of a hexokinase II inhibitor in an in vivo murine model was examined and its prognostic implication in HCC patients was investigated. CA-IX expression was evaluated using quantitative real-time...
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#1Jongsu Jun (SNU: Seoul National University)
#2Jungsoo Gim (SNU: Seoul National University)H-Index: 6
Last. Taesung Park (SNU: Seoul National University)H-Index: 35
view all 17 authors...
Discovering reliable protein biomarkers is one of the most important issues in biomedical research. The ELISA is a traditional technique for accurate quantitation of well-known proteins. Recently, the multiple reaction-monitoring (MRM) mass spectrometry has been proposed for quantifying newly discovered protein and has become a popular alternative to ELISA. For the MRM data analysis, linear mixed modeling (LMM) has been used to analyze MRM data. MSstats is one of the most widely used tools for M...
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