Match!
Young Youn Cho
Chung-Ang University
44Publications
9H-index
223Citations
Publications 44
Newest
#1Yun Bin Lee (SNU: Seoul National University)H-Index: 8
#2Joon Yeul Nam (SNU: Seoul National University)H-Index: 4
Last.Deok Hee Lee (SNU: Seoul National University)H-Index: 51
view all 10 authors...
#1Young Youn Cho (CAU: Chung-Ang University)H-Index: 9
#2Young Jun Chang (SNU: Seoul National University)H-Index: 19
Last.Yoon Jun Kim (SNU: Seoul National University)H-Index: 36
view all 9 authors...
#1Deok‑Gyun You (KU: Korea University)H-Index: 1
#2Young Youn Cho (SNU: Seoul National University)H-Index: 9
Last.Gi Young Lee (KU: Korea University)H-Index: 2
view all 10 authors...
Abstract Hepatitis B virus X protein (HBx) functions in a variety of cellular events during the HBV life cycle. In a previous study, we reported that the HBx protein is sufficient to induce mitochondrial membrane permeabilization; however, the exact mechanism of HBx-induced mitochondrial membrane permeabilization has been not proposed. In this study, we report that HBx specifically targets cardiolipin (CL) and induces membrane permeabilization depending on CL concentration in mitochondrial outer...
Background and Goals:Although nonalcoholic fatty liver disease (NAFLD) is a risk factor of hepatocellular carcinoma (HCC), it is unclear whether NAFLD additionally increases the risk of HCC among chronic hepatitis B (CHB) patients. This study evaluated the association between NAFLD and the risk of H
#1Eun Ju Cho (SNU: Seoul National University)H-Index: 15
#2Su Jong Yu (SNU: Seoul National University)H-Index: 19
Last.Hyewon Youn (SNU: Seoul National University)H-Index: 14
view all 10 authors...
Hypoxic conditions, which large or infiltrative hypovascular tumors may encounter, also produce acidic environments. Carbonic anhydrase-IX (CA-IX), an enzyme involved in lowering pH, is overexpressed in hepatocellular carcinoma (HCC). In the present study, whether inhibition of CA-IX enhances the efficacy of a hexokinase II inhibitor in an in vivo murine model was examined and its prognostic implication in HCC patients was investigated. CA-IX expression was evaluated using quantitative real-time...
#1J.-J. YooH-Index: 7
#2Jeong Ju Yoo (SCH: Soonchunhyang University)H-Index: 5
Last.Yoon Jun KimH-Index: 36
view all 10 authors...
This study aimed to examine whether inhibition of hexokinase (HK)-II activity enhances the efficacy of sorafenib in in-vivo models of hepatocellular carcinoma (HCC), and to evaluate the prognostic implication of HK-II expression in patients with HCC. We used 3-bromopyruvate (3-BP), a HK-II inhibitor to target HK-II. The human HCC cell line was tested as both subcutaneous and orthotopic tumor xenograft models in BALB/c nu/nu mice. The prognostic role of HK-II was evaluated in data from HCC patien...
#1Yun Bin Lee (SNU: Seoul National University)H-Index: 8
#2Joon Yeul Nam (SNU: Seoul National University)H-Index: 4
Last.Deok Hee Lee (SNU: Seoul National University)H-Index: 51
view all 10 authors...
Whether a sustained virological response (SVR) improves long-term outcomes in chronic hepatitis C patients with earlier-stage fibrosis has not been established. We investigated the differential effect of SVR on the risk of outcomes according to hepatic fibrosis grade. Fibrosis grade was categorised using FIB-4: <1.45, low-probability of significant fibrosis; 1.45–3.25, intermediate-probability; and ≥3.25, high-probability. Primary and secondary endpoints were hepatocellular carcinoma (HCC) occur...
#1Hwi Young Kim (Ewha Womans University)H-Index: 13
#2Dong Hyeon Lee (SNU: Seoul National University)H-Index: 12
Last.Jung-Hwan Yoon (SNU: Seoul National University)H-Index: 33
view all 8 authors...
Background Prediction of the outcome of sorafenib therapy using biomarkers is an unmet clinical need in patients with advanced hepatocellular carcinoma (HCC). The aim was to develop and validate a biomarker-based model for predicting sorafenib response and overall survival (OS).
#1Jongsu Jun (SNU: Seoul National University)
#2Jungsoo Gim (SNU: Seoul National University)H-Index: 6
Last.Dong Hyeon Lee (SNU: Seoul National University)H-Index: 12
view all 10 authors...
Discovering reliable protein biomarkers is one of the most important issues in biomedical research. The ELISA is a traditional technique for accurate quantitation of well-known proteins. Recently, the multiple reaction-monitoring (MRM) mass spectrometry has been proposed for quantifying newly discovered protein and has become a popular alternative to ELISA. For the MRM data analysis, linear mixed modeling (LMM) has been used to analyze MRM data. MSstats is one of the most widely used tools for M...
#1Young Youn Cho (CAU: Chung-Ang University)H-Index: 9
#2Su Jong Yu (SNU: Seoul National University)H-Index: 19
Last.Yoon Jun Kim (SNU: Seoul National University)H-Index: 36
view all 10 authors...
Background/Aims:Transarterial chemoembolization (TACE) is a major therapeutic modality for patients with unresectable hepatocellular carcinoma, which needs repeated treatments. Model to Estimate Survival in Ambulatory Hepatocellular carcinoma patients (MESIAH) was recently developed as a model for p
12345