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Jessica Holler
Emory University
SAMHD1Interferon gammaAryl hydrocarbon receptorBiologyCell biology
9Publications
3H-index
20Citations
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Publications 9
Newest
#1Minakshi Gandhi (DKFZ: German Cancer Research Center)
#2Matthias Groß (DKFZ: German Cancer Research Center)H-Index: 7
Last. Heike Allgayer (Heidelberg University)H-Index: 40
view all 12 authors...
Long intergenic non-coding RNA-Nucleotide Metabolism Regulator (lincNMR) is a long non-coding RNA (lncRNA) which is induced in hepatocellular carcinoma. Its depletion invokes a proliferation defect, triggers senescence and inhibits colony formation in liver, but also breast and lung cancer cells. Triple-label SILAC proteomics profiles reveal a deregulation of key cell cycle regulators in lincNMR-depleted cells like the key dNTP synthesizing enzymes RRM2, TYMS and TK1, implicating lincNMR in regu...
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#1Giada Zurlo (UNC: University of North Carolina at Chapel Hill)H-Index: 5
#2Xijuan Liu (UNC: University of North Carolina at Chapel Hill)H-Index: 3
Last. Qing ZhangH-Index: 26
view all 21 authors...
Protein hydroxylation affects protein stability, activity, and interactome, therefore contributing to various diseases including cancers. However, the transiency of the hydroxylation reaction hinders the identification of hydroxylase substrates. By developing an enzyme-substrate trapping strategy coupled with TAP-TAG or orthogonal GST- purification followed by mass spectrometry, we identify adenylosuccinate lyase (ADSL) as an EglN2 hydroxylase substrate in triple negative breast cancer (TNBC). A...
1 CitationsSource
#1Si’Ana A. Coggins (Emory University)H-Index: 2
#2Jessica Holler (Emory University)H-Index: 3
Last. Baek Kim (Kyung Hee University)H-Index: 36
view all 6 authors...
Abstract Unlike HIV-1, HIV-2 and some SIV strains replicate at high dNTP concentrations even in macrophages due to their accessory proteins, Vpx or Vpr, that target SAMHD1 dNTPase for proteasomal degradation. We previously reported that HIV-1 reverse transcriptase (RT) efficiently synthesizes DNA even at low dNTP concentrations because HIV-1 RT displays faster pre-steady state kpol values than SAMHD1 counteracting lentiviral RTs. Here, since the kpol step consists of two sequential sub-steps pos...
1 CitationsSource
#1Caitlin Shepard (Emory University)H-Index: 11
#2Joella Xu (Emory University)
Last. Baek Kim (Emory University)H-Index: 36
view all 7 authors...
Terminally differentiated/nondividing macrophages, a key target cell type of HIV-1, harbor extremely low dNTP concentrations established by a host dNTP triphosphohydrolase, SAM domain and HD domain containing protein 1 (SAMHD1). We tested whether the induction of dNTP pool imbalance can affect HIV-1 replication in macrophages. For this test, we induced a large dNTP pool imbalance by treating human primary monocyte derived macrophages with either one or three of the four deoxynucleosides (dNs), w...
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#1Sarah A. Mereby (Emory University)H-Index: 1
#2Tatsuya Maehigashi (Emory University)H-Index: 12
Last. Baek Kim (Kyung Hee University)H-Index: 36
view all 6 authors...
: Lentiviruses infect both dividing CD4+ T cells and nondividing myeloid cells, and the infected myeloid cells serve as long-living viral reservoirs. Host sterile alpha motif- and histidine-aspartate domain-containing protein 1 (SAMHD1) kinetically restricts reverse transcription of primate lentiviruses, including human immunodeficiency virus, type 1 (HIV-1) and simian immunodeficiency virus (SIV), in nondividing myeloid cells. SAMHD1 enforces this restriction through its dNTP triphosphohydrolas...
3 CitationsSource
#1Tonya Kueck (Rockefeller University)H-Index: 2
#2Elena Cassella (Rockefeller University)H-Index: 2
Last. Paul D. Bieniasz (Rockefeller University)H-Index: 67
view all 5 authors...
: The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor whose activation induces the expression of numerous genes, with many effects on cells. However, AhR activation is not known to affect the replication of viruses. We show that AhR activation in macrophages causes a block to HIV-1 and HSV-1 replication. We find that AhR activation transcriptionally represses cyclin-dependent kinase (CDK)1/2 and their associated cyclins, thereby reducing SAMHD1 phosphorylation, cellula...
4 CitationsSource
#1Tonya Kueck (Rockefeller University)H-Index: 2
#2Elena Cassella (Rockefeller University)H-Index: 2
Last. Paul D. Bieniasz (Rockefeller University)H-Index: 67
view all 5 authors...
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#2Kerstin SchottH-Index: 4
Last. Carsten MünkH-Index: 25
view all 11 authors...
The host intrinsic innate immune system drives antiviral defenses and viral restriction, which includes the production of soluble factors, such as type I and III interferon (IFN), and activation of restriction factors, including SAMHD1, a deoxynucleoside triphosphohydrolase. Interferon-stimulated gene 15 (ISG15)-specific ubiquitin-like protease 43 (USP18) abrogates IFN signaling pathways. The cyclin-dependent kinase inhibitor p21 (CIP1/WAF1), which is involved in the differentiation and maturati...
4 CitationsSource
#1Paul D. Bieniasz (Rockefeller University)H-Index: 67
#2Tonya Kueck (Rockefeller University)H-Index: 2
Last. Baek Kim (Emory University)H-Index: 36
view all 5 authors...
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor whose activation induces the expression of numerous genes, with many effects on cells. However, AhR activation is not known to affect the replication of viruses. We show that AhR activation in macrophages causes a block to HIV-1 and HSV-1 replication. We find that AhR activation transcriptionally represses cyclin-dependent kinase (CDK)1/2 and their associated cyclins, thereby reducing SAMHD1 phosphorylation, cellular ...
Source
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