Robert Clarke
Clinical Trial Service Unit
Publications 1842
Summary Background Cooking practice has transitioned from use of solid fuels to use of clean fuels, with addition of better ventilation facilities. However, the change in mortality risk associated with such a transition remains unclear. Methods The China Kadoorie Biobank (CKB) Study enrolled participants (aged 30–79 years) from ten areas across China; we chose to study participants from five urban areas where transition from use of solid fuels to clean fuels for cooking was prevalent. Participan...
1 CitationsSource
#1Ming FanH-Index: 9
#2Yitan ZhuH-Index: 13
Last.YueJosephWANGH-Index: 37
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Abstract Much of the discussion of personalized medicine has been focused on molecular characterization of tissue samples using genomic and proteomic technologies. However, as lesions are spatially and temporally heterogeneous, these techniques are limited. They require biopsies or invasive surgeries to extract generally small portions of tumor tissue that do not allow for complete characterization of the lesion. On the contrary, imaging is noninvasive and has already been often repeated in rout...
Importance Vitamin D and calcium supplements are recommended for the prevention of fracture, but previous randomized clinical trials (RCTs) have reported conflicting results, with uncertainty about optimal doses and regimens for supplementation and their overall effectiveness. Objective To assess the risks of fracture associated with differences in concentrations of 25-hydroxyvitamin D (25[OH]D) in observational studies and the risks of fracture associated with supplementation with vitamin D alo...
Objective Aim to examine the independent and joint associations of physical activity (PA) and sedentary leisure-time (SLT) with risk of diabetes and assess the extent to which these associations were mediated by adiposity. Research design and methods The prospective China Kadoorie Biobank recruited ~512 000 adults from 10 diverse areas across China. Self-reported PA was estimated based on type, frequency and duration of specific types of PA, covering four domains (occupation, leisure, household ...
Dissemination of tumour cells to the bone marrow is an early event in breast cancer, however cells may lie dormant for many years before bone metastases develop. Treatment for bone metastases is not curative, therefore new adjuvant therapies which prevent the colonisation of disseminated cells into metastatic lesions are required. There is evidence that cancer stem cells (CSCs) within breast tumours are capable of metastasis, but the mechanism by which these colonise bone is unknown. Here, we es...
#1Yuanjie Pang (Clinical Trial Service Unit)H-Index: 6
#2Christiana Kartsonaki (Medical Research Council)H-Index: 9
Last.Zhengming Chen (Clinical Trial Service Unit)H-Index: 47
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Adiposity is an increasing public health problem in China. We aimed to examine the associations of adiposity with non-alcoholic fatty liver disease (NAFLD) and other chronic liver diseases in Chinese adults. The prospective China Kadoorie Biobank recruited 512,891 adults aged 30–79 years from 10 areas. During 10 years of follow-up, 7,386 incident liver disease cases were recorded among 503,991 participants without prior cancer or chronic liver disease at baseline. The mean body mass index (BMI) ...
2 CitationsSource
Last.Robert ClarkeH-Index: 135
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#1Lana McClements (UTS: University of Technology, Sydney)H-Index: 7
#2Stephanie Annett ('QUB': Queen's University Belfast)H-Index: 2
Last.Tracy Robson ('QUB': Queen's University Belfast)H-Index: 28
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Optimising breast cancer treatment remains a challenge. Resistance to therapy is a major problem in both ER- and ER+ breast cancer. Tumour recurrence after chemotherapy and/or targeted therapy leads to more aggressive tumours with enhanced metastatic ability. Self-renewing cancer stem cells (CSCs) have been implicated in treatment resistance, recurrence and the development of metastatic disease. In this study, we utilised in vitro, in vivo and ex vivo breast cancer models using ER+ MCF-7 and ER-...
2 CitationsSource