Alison Offer
Clinical Trial Service Unit
Publications 18
#1Alison Offer (Clinical Trial Service Unit)H-Index: 9
#2M Arnold (Clinical Trial Service Unit)H-Index: 1
Last.Jing Li (Peking Union Medical College)
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Importance Acquisition of reliable randomized clinical trial evidence of the effects of cardiovascular interventions on cognitive decline is a priority. Objectives To estimate the association of cognitive aging with the avoidance of vascular events in cardiovascular intervention trials and understand whether reports of nonsignificant results exclude worthwhile benefit. Design, Setting, and Participants This secondary analysis of 3 randomized clinical trials in participants with preexisting occlu...
#1S ParishH-Index: 55
#2Jemma C. HopewellH-Index: 38
Last.Rory CollinsH-Index: 131
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Background: Genetic studies have shown lipoprotein(a) (Lp[a]) to be an important causal risk factor for coronary disease. Apolipoprotein(a) isoform size is the chief determinant of Lp(a) levels, but its impact on the benefits of therapies that lower Lp(a) remains unclear. Methods: HPS2-THRIVE (Heart Protection Study 2–Treatment of HDL to Reduce the Incidence of Vascular Events) is a randomized trial of niacin–laropiprant versus placebo on a background of simvastatin therapy. Plasma Lp(a) levels ...
#1S Parish (Clinical Trial Service Unit)H-Index: 55
#2Alison Offer (Clinical Trial Service Unit)H-Index: 9
Last.Rory Collins (Clinical Trial Service Unit)H-Index: 131
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Background—Low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol are established risk factors for vascular disease, but lipoprotein particle concentrations may be stronger determinants of risk. Methods and Results—Associations between vascular events and baseline concentrations of cholesterol fractions, apolipoproteins B and A1, and lipoprotein particles assessed by nuclear magnetic resonance were considered in the Heart Protection Study randomized trial of sim...
#1Zhengming Chen (CCDC: Chinese Center for Disease Control and Prevention)H-Index: 46
#2Gonghuan Yang (CCDC: Chinese Center for Disease Control and Prevention)H-Index: 7
Last.Gary Whitlock (CCDC: Chinese Center for Disease Control and Prevention)H-Index: 27
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(HRs) and 95% confidence intervals (95% CIs) per 5 kg/m 2 calculated within either a lower (15 to <23.5 kg/m 2 ) or higher (23.5 to <35 kg/m 2 ) range. Results The association between BMI and all-cause mortality was U-shaped with the lowest mortality at � 22.5–25 kg/m 2 . In the lower range, 5 kg/m 2 higher BMI was associated with 14% lower mortality (HR 0.86, 95% CI 0.82–0.91); in the upper range, it was associated with 27% higher mortality (HR 1.27, 95% CI 1.15–1.40). The absolute excess morta...