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Alison Offer
Clinical Trial Service Unit
18Publications
9H-index
934Citations
Publications 18
Newest
Published on Mar 1, 2019
Alison Offer9
Estimated H-index: 9
(Clinical Trial Service Unit),
M Arnold1
Estimated H-index: 1
(Clinical Trial Service Unit)
+ 11 AuthorsMartin J. Landray32
Estimated H-index: 32
(Clinical Trial Service Unit)
Importance Acquisition of reliable randomized clinical trial evidence of the effects of cardiovascular interventions on cognitive decline is a priority. Objectives To estimate the association of cognitive aging with the avoidance of vascular events in cardiovascular intervention trials and understand whether reports of nonsignificant results exclude worthwhile benefit. Design, Setting, and Participants This secondary analysis of 3 randomized clinical trials in participants with preexisting occlu...
Source Cite
Published on Jan 1, 2019in JAMA 47.66
Parish Sarah. , Alison Offer9
Estimated H-index: 9
+ 9 AuthorsMartin J. Landray32
Estimated H-index: 32
Published on Feb 1, 2018
S Parish55
Estimated H-index: 55
,
Jemma C. Hopewell38
Estimated H-index: 38
+ 9 AuthorsRory Collins131
Estimated H-index: 131
Background: Genetic studies have shown lipoprotein(a) (Lp[a]) to be an important causal risk factor for coronary disease. Apolipoprotein(a) isoform size is the chief determinant of Lp(a) levels, but its impact on the benefits of therapies that lower Lp(a) remains unclear. Methods: HPS2-THRIVE (Heart Protection Study 2–Treatment of HDL to Reduce the Incidence of Vascular Events) is a randomized trial of niacin–laropiprant versus placebo on a background of simvastatin therapy. Plasma Lp(a) levels ...
8 Citations Source Cite
Published on Aug 1, 2015in European Heart Journal 23.43
S Parish55
Estimated H-index: 55
,
Alison Offer9
Estimated H-index: 9
+ 8 AuthorsRory Collins131
Estimated H-index: 131
Published on Jun 17, 2013
John F. Peden46
Estimated H-index: 46
,
Jemma C. Hopewell38
Estimated H-index: 38
+ 99 AuthorsMartin Farrall87
Estimated H-index: 87
Source Cite
Published on Apr 1, 2013in European Heart Journal 23.43
Jemma C. Hopewell38
Estimated H-index: 38
(University of Oxford),
S Parish55
Estimated H-index: 55
(University of Oxford)
+ 5 AuthorsRory Collins131
Estimated H-index: 131
(University of Oxford)
Aims Statins reduce LDL cholesterol (LDL-C) and the risk of vascular events, but it remains uncertain whether there is clinically relevant genetic variation in their efficacy. This study of 18 705 individuals aims to identify genetic variants related to the lipid response to simvastatin and assess their impact on vascular risk response. Methods and results A genome-wide study of the LDL-C and apolipoprotein B (ApoB) response to 40 mg simvastatin daily was performed in 3895 participants in the He...
59 Citations Source Cite
Published on May 22, 2012in Circulation 18.88
S Parish55
Estimated H-index: 55
(Clinical Trial Service Unit),
Alison Offer9
Estimated H-index: 9
(Clinical Trial Service Unit)
+ 5 AuthorsRory Collins131
Estimated H-index: 131
(Clinical Trial Service Unit)
Background—Low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol are established risk factors for vascular disease, but lipoprotein particle concentrations may be stronger determinants of risk. Methods and Results—Associations between vascular events and baseline concentrations of cholesterol fractions, apolipoproteins B and A1, and lipoprotein particles assessed by nuclear magnetic resonance were considered in the Heart Protection Study randomized trial of sim...
130 Citations Source Cite
Published on Apr 1, 2012in International Journal of Epidemiology 8.36
Zhengming Chen46
Estimated H-index: 46
(Chinese Center for Disease Control and Prevention),
Gonghuan Yang7
Estimated H-index: 7
(Chinese Center for Disease Control and Prevention)
+ 6 AuthorsGary Whitlock27
Estimated H-index: 27
(Chinese Center for Disease Control and Prevention)
(HRs) and 95% confidence intervals (95% CIs) per 5 kg/m 2 calculated within either a lower (15 to <23.5 kg/m 2 ) or higher (23.5 to <35 kg/m 2 ) range. Results The association between BMI and all-cause mortality was U-shaped with the lowest mortality at � 22.5–25 kg/m 2 . In the lower range, 5 kg/m 2 higher BMI was associated with 14% lower mortality (HR 0.86, 95% CI 0.82–0.91); in the upper range, it was associated with 27% higher mortality (HR 1.27, 95% CI 1.15–1.40). The absolute excess morta...
70 Citations Source Cite
Published on Jan 1, 2012in European Heart Journal 23.43
Jemma C. Hopewell38
Estimated H-index: 38
,
Alison Offer9
Estimated H-index: 9
+ 7 AuthorsGrp H-Tc.2
Estimated H-index: 2
7 Citations
12