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Shoumo Bhattacharya
Wellcome Trust
149Publications
41H-index
6,851Citations
Publications 144
Newest
#1Yongjie Yang (BCM: Baylor College of Medicine)H-Index: 9
#2Agatha A. van der Klaauw (University of Cambridge)H-Index: 16
Last.Weihua ZhangH-Index: 63
view all 265 authors...
Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion of SRC-1 in Pomc neurons in mice attenuates their depolarization by leptin, decreases Pomc expression and increases food intake leading to high-fat diet-induced obesity. In humans, fifteen rare heterozy...
12 CitationsSource
#1Erika Yan Wang (U of T: University of Toronto)H-Index: 4
#2Naimeh Rafatian (U of T: University of Toronto)H-Index: 3
Last.Milica Radisic (U of T: University of Toronto)H-Index: 53
view all 12 authors...
Myocardial fibrosis is a severe global health problem due to its prevalence in all forms of cardiac diseases and direct role in causing heart failure. The discovery of efficient antifibrotic compounds has been hampered due to the lack of a physiologically relevant disease model. Herein, we present a disease model of human myocardial fibrosis and use it to establish a compound screening system. In the Biowire II platform, cardiac tissues are suspended between a pair of poly(octamethylene maleate ...
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#1Angela W. Lee (University of Oxford)
#2Maud DeruazH-Index: 13
Last.Shoumo Bhattacharya (University of Oxford)H-Index: 41
view all 12 authors...
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#1Rui Gao (MPG: Max Planck Society)H-Index: 1
#2Xingqun Liang (Tongji University)H-Index: 16
Last.Gergana DobrevaH-Index: 15
view all 18 authors...
Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of ...
5 CitationsSource
#1Donna J. Page (MAHSC: Manchester Academic Health Science Centre)H-Index: 1
#2Matthieu J. Miossec (Andrés Bello National University)H-Index: 1
Last.Bernard Keavney (MAHSC: Manchester Academic Health Science Centre)H-Index: 46
view all 34 authors...
Rationale: Familial recurrence studies provide strong evidence for a genetic component to the predisposition to sporadic, nonsyndromic Tetralogy of Fallot (TOF), the most common cyanotic congenital...
5 CitationsSource
#1Jade Bailey (John Radcliffe Hospital)H-Index: 2
#2Simon J. Davis (University of Oxford)H-Index: 51
Last.Mark J. Crabtree (John Radcliffe Hospital)H-Index: 24
view all 12 authors...
Nitric Oxide (NO) is an intracellular signalling mediator, which affects many biological processes via the posttranslational modification of proteins through S-nitrosation. The availability of NO and NOS-derived reactive oxygen species (ROS) from enzymatic uncoupling are determined by the NO synthase cofactor Tetrahydrobiopterin (BH4). Here, using a global proteomics “biotin-switch” approach, we identified components of the ubiquitin-proteasome system to be altered via BH4-dependent NO signallin...
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#1Iain M. Dykes (University of Oxford)H-Index: 9
#2Dorota Szumska (University of Oxford)H-Index: 13
Last.Shoumo Bhattacharya (University of Oxford)H-Index: 41
view all 17 authors...
ZIC2 mutation is known to cause holoprosencephaly (HPE). A subset of ZIC2 HPE probands harbour cardiovascular and visceral anomalies suggestive of laterality defects. 3D-imaging of novel mouse Zic2 mutants uncovers, in addition to HPE, laterality defects in lungs, heart, vasculature and viscera. A strong bias towards right isomerism indicates a failure to establish left identity in the lateral plate mesoderm (LPM), a phenotype that cannot be explained simply by the defective ciliogenesis previou...
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#1Yara Alenazi (University of Oxford)H-Index: 3
#2Kamayani Singh (University of Oxford)H-Index: 3
Last.Shoumo Bhattacharya (University of Oxford)H-Index: 41
view all 7 authors...
Both CC and CXC-class chemokines drive inflammatory disease. Tick salivary chemokine-binding proteins (CKBPs), or evasins, specifically bind subsets of CC- or CXC-chemokines, and could precisely target disease-relevant chemokines. Here we have used yeast surface display to identify two tick evasins: a CC-CKBP, P1243 from Amblyomma americanum and a CXC-CKBP, P1156 from Ixodes ricinus. P1243 binds 11 CC-chemokines with Kd < 10 nM, and 10 CC-chemokines with Kd between 10 and 100 nM. P1156 binds two...
3 CitationsSource
8 CitationsSource
#1Donna J. Page (University of Manchester)H-Index: 1
#2Matthieu J. Miossec (Andrés Bello National University)H-Index: 1
Last.Bernard Keavney (University of Manchester)H-Index: 46
view all 34 authors...
Aims: Familial recurrence studies provide strong evidence for a genetic component to the predisposition to sporadic, non-syndromic Tetralogy of Fallot (TOF), the most common cyanotic congenital heart disease (CHD) phenotype. Rare genetic variants have been identified as important contributors to the risk of CHD, but relatively small numbers of TOF cases have been studied to date. Here, we use whole exome sequencing to assess the prevalence of rare, potentially deleterious variants in candidate g...
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