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Nurshat Gaifullin
Moscow State University
22Publications
8H-index
171Citations
Publications 22
Newest
#1Maria SuntsovaH-Index: 9
#2Nurshat Gaifullin (MSU: Moscow State University)H-Index: 8
Last.Anton Buzdin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
view all 14 authors...
Comprehensive analysis of molecular pathology requires a collection of reference samples representing normal tissues from healthy donors. For the available limited collections of normal tissues from postmortal donors, there is a problem of data incompatibility, as different datasets generated using different experimental platforms often cannot be merged in a single panel. Here, we constructed and deposited the gene expression database of normal human tissues based on uniformly screened original ...
2 CitationsSource
#1Daniil NikitinH-Index: 3
#2Andrew GarazhaH-Index: 10
Last.Anton BuzdinH-Index: 26
view all 10 authors...
In the article ‘Retroelement—Linked Transcription Factor Binding Patterns Point to Quickly Developing Molecular Pathways in Human Evolution,’ a number of transcription factor binding sites (TFBS) mapped on all retroelement classes were incorrectly calculated as sum of TFBS numbers separately mapped on LINEs, SINEs and LTR retrotransposons/endogenous retroviruses (LR/ERVs) [...]
Source
#1Anton Buzdin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
#2Maxim Sorokin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
Last.Alexey Moiseev (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 1
view all 14 authors...
Abstract Molecular diagnostics is becoming one of the major drivers of personalized oncology. With hundreds of different approved anticancer drugs and regimens of their administration, selecting the proper treatment for a patient is at least nontrivial task. This is especially sound for the cases of recurrent and metastatic cancers where the standard lines of therapy failed. Recent trials demonstrated that mutation assays have a strong limitation in personalized selection of therapeutics, conseq...
1 CitationsSource
#1Anton BuzdinH-Index: 26
#2Andrew GarazhaH-Index: 10
Last.Nurshat Gaifullin (MSU: Moscow State University)H-Index: 8
view all 11 authors...
e13032Background: Intracellular molecular pathways (IMPs) control all major events in the living cell. They are considered hotspots in contemporary oncology because knowledge of IMPs activation is ...
Source
#1Elena PoddubskayaH-Index: 6
#2Anton BuzdinH-Index: 26
Last.Nikolay M. Borisov (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 14
view all 17 authors...
e13143Background: Anticancer Targeted Drugs (ATDs) specifically target one or a few types of tumor-related molecules in a cell. More than two hundred of ATDs were approved worldwide. They have diff...
1 CitationsSource
#1Daniil NikitinH-Index: 3
#2Andrew GarazhaH-Index: 10
Last.Anton BuzdinH-Index: 26
view all 10 authors...
Background: Retroelements (REs) are transposable elements occupying ~40% of the human genome that can regulate genes by providing transcription factor binding sites (TFBS). RE-linked TFBS profile can serve as a marker of gene transcriptional regulation evolution. This approach allows for interrogating the regulatory evolution of organisms with RE-rich genomes. We aimed to characterize the evolution of transcriptional regulation for human genes and molecular pathways using RE-linked TFBS accumula...
5 CitationsSource
Source
#1Ivan PetrovH-Index: 3
#2Maria SuntsovaH-Index: 9
Last.Anton BuzdinH-Index: 26
view all 15 authors...
// Ivan Petrov 1, 2, 3, 4 , Maria Suntsova 1, 5 , Elena Ilnitskaya 2 , Sergey Roumiantsev 6 , Maxim Sorokin 7, 8 , Andrew Garazha 1, 9 , Pavel Spirin 10 , Timofey Lebedev 10 , Nurshat Gaifullin 11 , Sergey Larin 1 , Olga Kovalchuk 12 , Dmitry Konovalov 1, 13 , Vladimir Prassolov 10 , Alexander Roumiantsev 1 and Anton Buzdin 1, 5, 7 1 D. Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia 2 First Oncology Research and Advisory Center, Moscow, Russia 3...
9 CitationsSource
#1Nicolas Borisov (Kurchatov Institute)H-Index: 8
#2Maria SuntsovaH-Index: 9
Last.Anton Buzdin (Kurchatov Institute)H-Index: 9
view all 21 authors...
ABSTRACTHigh throughput technologies opened a new era in biomedicine by enabling massive analysis of gene expression at both RNA and protein levels. Unfortunately, expression data obtained in different experiments are often poorly compatible, even for the same biologic samples. Here, using experimental and bioinformatic investigation of major experimental platforms, we show that aggregation of gene expression data at the level of molecular pathways helps to diminish cross- and intra-platform bia...
17 CitationsSource
#1Anton BuzdinH-Index: 26
#2Maxim SorokinH-Index: 9
Last.Nicolas BorisovH-Index: 8
view all 15 authors...
e23142Background: Anticancer target drugs (ATDs) specifically bind and inhibit molecular targets that play important roles in tumorigenesis. More than 150 different ATDs have been approved for clinical use worldwide, and the clinicians are faced with the problem of choosing the best therapeutic solution for each patient. The problem of efficient ATD selection remains largely unsolved and personalized approaches are needed to select the best ATD candidates for individual patients. Methods: We pro...
6 CitationsSource
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