Yea Na Ha
Konkuk University
VirologyHepatitis B virusHBxBiologyHepatocyte nuclear factors
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Publications 5
#1Soree Park (Konkuk University)H-Index: 8
#2Yea Na Ha (Konkuk University)H-Index: 3
Last. Jae Jin Shin (Konkuk University)
view all 12 authors...
Hepatitis B virus (HBV) infection is a major factor in the development of various liver diseases such as hepatocellular carcinoma (HCC). Among HBV encoded proteins, HBV X protein (HBx) is known to play a key role in the development of HCC. Hepatocyte nuclear factor 4α (HNF4α) is a nuclear transcription factor which is critical for hepatocyte differentiation. However, the expression level as well as its regulatory mechanism in HBV infection have yet to be clarified. Here, we observed the suppress...
#1Eun-Sook Park (Konkuk University)H-Index: 11
#2Ah Ram Lee (Konkuk University)H-Index: 7
Last. Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 26 authors...
Background & Aims Tenofovir disoproxil fumarate (TDF) is one the most potent nucleot(s)ide analogues for treating chronic hepatitis B virus (HBV) infection. Phenotypic resistance caused by genotypic resistance to TDF has not been reported. This study aimed to characterize HBV mutations that confer tenofovir resistance. Methods Two patients with viral breakthrough during treatment with TDF-containing regimens were prospectively enrolled. The gene encoding HBV reverse transcriptase was sequenced. ...
5 CitationsSource
#1Eun-Sook Park (Konkuk University)H-Index: 11
#2Young-Ho Byun (Yonsei University)H-Index: 14
Last. Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 25 authors...
: The multifunctional influenza virus protein PB1-F2 plays several roles in deregulation of host innate immune responses and is a known immunopathology enhancer of the 1918 influenza pandemic. Here, we show that the 1918 PB1-F2 protein not only interferes with the mitochondria-dependent pathway of type I interferon (IFN) signaling, but also acquired a novel IFN antagonist function by targeting the DEAD-box helicase DDX3, a key downstream mediator in antiviral interferon signaling, toward proteas...
3 CitationsSource
#1Doo Hyun Kim (Konkuk University)H-Index: 9
#2Eun-Sook Park (Konkuk University)H-Index: 11
Last. Kyun-Hwan Kim (Konkuk University)H-Index: 22
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Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown. Here we show that interleukin-32 (IL-32) is induced by TNF and IFN-γ in hepatocytes, and inhibits the replication of HBV by acting intracellularly to suppress HBV transcription an...
3 CitationsSource
#1Ah Ram Lee (Konkuk University)H-Index: 7
#2Keo Heun Lim (Konkuk University)H-Index: 1
Last. Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 15 authors...
Hepatitis B virus (HBV) infection is a leading cause of liver diseases; however, the host factors which facilitate the replication and persistence of HBV are largely unidentified. Cellular FLICE inhibitory protein (c-FLIP) is a typical antiapoptotic protein. In many cases of liver diseases, the expression level of c-FLIP is altered, which affects the fate of hepatocytes. We previously found that c-FLIP and its cleaved form interact with HBV X protein (HBx), which is essential for HBV replication...
1 CitationsSource