Friederike Cuello
University of Hamburg
17Publications
6H-index
112Citations
Publications 17
Newest
Published on Feb 10, 2019in Annual Review of Physiology 14.33
Friederike Cuello6
Estimated H-index: 6
(University of Hamburg),
Philip Eaton33
Estimated H-index: 33
(St Thomas' Hospital)
Oxidant molecules are produced in biological systems and historically have been considered causal mediators of damage and disease. While oxidants may contribute to the pathogenesis of disease, evidence continues to emerge that shows these species also play important regulatory roles in health. A major mechanism of oxidant sensing and signaling involves their reaction with reactive cysteine thiols within proteins, inducing oxidative posttranslational modifications that can couple to altered funct...
1 Citations Source Cite
Published on Oct 1, 2018in Molecular Aspects of Medicine 7.34
Friederike Cuello6
Estimated H-index: 6
(University of Hamburg),
Ilka Wittig37
Estimated H-index: 37
(Goethe University Frankfurt)
+ 1 AuthorsPhilip Eaton33
Estimated H-index: 33
(King's College London)
Abstract Oxidants are produced endogenously and can react with and thereby post-translationally modify target proteins. They have been implicated in the redox regulation of signal transduction pathways conferring protection, but also in mediating oxidative stress and causing damage. The difference is that in scenarios of injury the amount of oxidants generated is higher and/or the duration of oxidant exposure sustained. In the cardiovascular system, oxidants are important for blood pressure home...
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Published on Dec 1, 2017in Scientific Reports 4.12
Sonia Donzelli17
Estimated H-index: 17
(École Polytechnique Fédérale de Lausanne),
Mara Goetz1
Estimated H-index: 1
(University of Hamburg)
+ 18 AuthorsChristian Dees14
Estimated H-index: 14
Despite the mechanisms for endogenous nitroxyl (HNO) production and action being incompletely understood, pharmacological donors show broad therapeutic promise and are in clinical trials. Mass spectrometry and site-directed mutagenesis showed that chemically distinct HNO donors 1-nitrosocyclohexyl acetate or Angeli's salt induced disulfides within cGMP-dependent protein kinase I-alpha (PKGI alpha), an interdisulfide between Cys42 of the two identical subunits of the kinase and a previously unobs...
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Published on Oct 1, 2017in BMC Clinical Pharmacology
G. Todd Milne4
Estimated H-index: 4
(Ironwood Pharmaceuticals),
Peter Sandner24
Estimated H-index: 24
(Bayer)
+ 387 AuthorsChris Sarko3
Estimated H-index: 3
(Boehringer Ingelheim)
1 Citations Source Cite
Published on Nov 1, 2017in Free Radical Biology and Medicine 6.02
Friederike Cuello6
Estimated H-index: 6
(University of Hamburg)
Oxidants can induce intra-and interdisulfide formation in protein kinases. This has been reported to regulate kinase activity by altering their cellular compartmentalization, relieving an inhibitory structure or by mimicking second messenger binding. For protein kinases as cAMP- and cGMP-dependent protein kinase, structural evidence confirmed indeed the presence of such disulfide modifications. Studies performed in redox-dead mice that can no longer form disulfides in a target protein in respons...
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Published on May 1, 2016in The FASEB Journal 5.59
Konstantina Stathopoulou12
Estimated H-index: 12
(University of Hamburg),
Ilka Wittig37
Estimated H-index: 37
(Goethe University Frankfurt)
+ 15 AuthorsEwald Schröder8
Estimated H-index: 8
(King's College London)
Cardiac myosin-binding protein C (cMyBP-C) regulates actin-myosin interaction and thereby cardiac myocyte contraction and relaxation. This physiologic function is regulated by cMyBP-C phosphorylation. In our study, reduced site-specific cMyBP-C phosphorylation coincided with increased S-glutathiolation in ventricular tissue from patients with dilated or ischemic cardiomyopathy compared to nonfailing donors. We used redox proteomics, to identify constitutive and disease-specific S-glutathiolation...
8 Citations Source Cite
Published on Nov 1, 2016in Free Radical Biology and Medicine 6.02
Oleksandra Prysyazhna11
Estimated H-index: 11
(King's College London),
Jenna Scotcher3
Estimated H-index: 3
(King's College London)
+ 15 AuthorsFriederike Cuello6
Estimated H-index: 6
(University of Hamburg)
The Frank-Starling law describes a regulatory mechanism that allows the amount of blood that enters the heart to be precisely matched with the amount that is pumped out to the arterial circulation, independently of external regulation. Mechanisms that contribute to the Frank-Starling response include stretch-induced increases in myofilament overlap, myofilament Ca 2+ sensitivity and actin-myosin cross-bridge formation. Recently, it was reported that there is also an increased production of oxida...
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Published on Dec 1, 2016in Nature Communications 12.35
Jenna Scotcher3
Estimated H-index: 3
(King's College London),
Oleksandra Prysyazhna11
Estimated H-index: 11
(King's College London)
+ 15 AuthorsFriederike Cuello6
Estimated H-index: 6
(University of Hamburg)
The Frank–Starling mechanism allows the amount of blood entering the heart from the veins to be precisely matched with the amount pumped out to the arterial circulation. As the heart fills with blood during diastole, the myocardium is stretched and oxidants are produced. Here we show that protein kinase G Iα (PKGIα) is oxidant-activated during stretch and this form of the kinase selectively phosphorylates cardiac phospholamban Ser16—a site important for diastolic relaxation. We find that hearts ...
14 Citations Source Cite
Published on Feb 3, 2016in PLOS ONE 2.77
Fabian Jacob1
Estimated H-index: 1
(University of Hamburg),
Amina Y. Yonis1
Estimated H-index: 1
(National Institutes of Health)
+ 11 AuthorsSebastian Schaaf10
Estimated H-index: 10
(University of Hamburg)
Introduction Left ventricular dysfunction is a frequent and potentially severe side effect of many tyrosine kinase inhibitors (TKI). The mode of toxicity is not identified, but may include impairment of mitochondrial or sarcomeric function, autophagy or angiogenesis, either as an on-target or off-target mechanism. Methods and Results We studied concentration-response curves and time courses for nine TKIs in three-dimensional, force generating engineered heart tissue (EHT) from neonatal rat heart...
10 Citations Source Cite
Published on Nov 1, 2016in Basic Research in Cardiology 5.72
Friederike Cuello6
Estimated H-index: 6
(University of Hamburg),
Kristina Lorenz20
Estimated H-index: 20
4 Citations Source Cite
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