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Friederike Cuello
University of Hamburg
21Publications
6H-index
125Citations
Publications 21
Newest
Published on Apr 5, 2019in Scientific Reports 4.12
Andreas T. Schaefer23
Estimated H-index: 23
(University of Hamburg),
Y. Schneeberger4
Estimated H-index: 4
(University of Hamburg)
+ 14 AuthorsKristina Lorenz21
Estimated H-index: 21
Mechanical unloading (MU) by implantation of left ventricular assist devices (LVAD) has become clinical routine. This procedure has been shown to reverse cardiac pathological remodeling, with the underlying molecular mechanisms incompletely understood. Most studies thus far were performed in non-standardized human specimens or MU of healthy animal hearts. Our study investigates cardiac remodeling processes in sham-operated healthy rat hearts and in hearts subjected to standardized pathological p...
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Published on Feb 10, 2019in Annual Review of Physiology 14.33
Friederike Cuello6
Estimated H-index: 6
(University of Hamburg),
Philip Eaton34
Estimated H-index: 34
(St Thomas' Hospital)
Oxidant molecules are produced in biological systems and historically have been considered causal mediators of damage and disease. While oxidants may contribute to the pathogenesis of disease, evidence continues to emerge that shows these species also play important regulatory roles in health. A major mechanism of oxidant sensing and signaling involves their reaction with reactive cysteine thiols within proteins, inducing oxidative posttranslational modifications that can couple to altered funct...
2 Citations Source Cite
Published on Oct 1, 2018in Molecular Aspects of Medicine 7.34
Friederike Cuello6
Estimated H-index: 6
(University of Hamburg),
Ilka Wittig37
Estimated H-index: 37
(Goethe University Frankfurt)
+ 1 AuthorsPhilip Eaton34
Estimated H-index: 34
(King's College London)
Abstract Oxidants are produced endogenously and can react with and thereby post-translationally modify target proteins. They have been implicated in the redox regulation of signal transduction pathways conferring protection, but also in mediating oxidative stress and causing damage. The difference is that in scenarios of injury the amount of oxidants generated is higher and/or the duration of oxidant exposure sustained. In the cardiovascular system, oxidants are important for blood pressure home...
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Published on Dec 1, 2017in Scientific Reports 4.12
Sonia Donzelli17
Estimated H-index: 17
(École Polytechnique Fédérale de Lausanne),
Mara Goetz1
Estimated H-index: 1
(University of Hamburg)
+ 18 AuthorsChristian Dees15
Estimated H-index: 15
Despite the mechanisms for endogenous nitroxyl (HNO) production and action being incompletely understood, pharmacological donors show broad therapeutic promise and are in clinical trials. Mass spectrometry and site-directed mutagenesis showed that chemically distinct HNO donors 1-nitrosocyclohexyl acetate or Angeli’s salt induced disulfides within cGMP-dependent protein kinase I-alpha (PKGIα), an interdisulfide between Cys42 of the two identical subunits of the kinase and a previously unobserved...
2 Citations Source Cite
Published on Nov 1, 2017in Free Radical Biology and Medicine 6.02
Friederike Cuello6
Estimated H-index: 6
(University of Hamburg)
Oxidants can induce intra-and interdisulfide formation in protein kinases. This has been reported to regulate kinase activity by altering their cellular compartmentalization, relieving an inhibitory structure or by mimicking second messenger binding. For protein kinases as cAMP- and cGMP-dependent protein kinase, structural evidence confirmed indeed the presence of such disulfide modifications. Studies performed in redox-dead mice that can no longer form disulfides in a target protein in respons...
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Published on Oct 1, 2017in BMC Clinical Pharmacology
G. Todd Milne4
Estimated H-index: 4
(Ironwood Pharmaceuticals),
Peter Sandner24
Estimated H-index: 24
(Bayer)
+ 387 AuthorsChris Sarko3
Estimated H-index: 3
(Boehringer Ingelheim)
1 Citations Source Cite
Published on Feb 3, 2017in Thoracic and Cardiovascular Surgeon 1.54
Andreas T. Schaefer23
Estimated H-index: 23
,
Y. Schneeberger4
Estimated H-index: 4
+ 6 AuthorsFriederike Cuello6
Estimated H-index: 6
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Published on Dec 1, 2016in Nature Communications 12.35
Jenna Scotcher3
Estimated H-index: 3
(King's College London),
Oleksandra Prysyazhna12
Estimated H-index: 12
(King's College London)
+ 15 AuthorsFriederike Cuello6
Estimated H-index: 6
(University of Hamburg)
The Frank–Starling mechanism allows the amount of blood entering the heart from the veins to be precisely matched with the amount pumped out to the arterial circulation. As the heart fills with blood during diastole, the myocardium is stretched and oxidants are produced. Here we show that protein kinase G Iα (PKGIα) is oxidant-activated during stretch and this form of the kinase selectively phosphorylates cardiac phospholamban Ser16—a site important for diastolic relaxation. We find that hearts ...
16 Citations Source Cite
Published on Nov 1, 2016in Basic Research in Cardiology 5.72
Friederike Cuello6
Estimated H-index: 6
(University of Hamburg),
Kristina Lorenz21
Estimated H-index: 21
5 Citations Source Cite
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