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Shelly Gapil Tiamas
University of Malaya
Enantioselective synthesisOrganic chemistryCycloadditionMyrceneTotal synthesis
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#1Shelly Gapil Tiamas (UM: University of Malaya)
#2Florian Daressy (Institut de Chimie des Substances Naturelles)
Last. Khalijah Awang (UM: University of Malaya)H-Index: 29
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Abstract A library of 26 novel carboxamides deriving from natural fislatifolic acid has been prepared. The synthetic strategy involved a bio-inspired Diels-Alder cycloaddition, followed by functionalisations of the carbonyl moiety. All the compounds were evaluated on Bcl-xL, Mcl-1 and Bcl-2 proteins. In this series of cyclohexenyl chalcone analogues, six compounds behaved as dual Bcl-xL/Mcl-1 inhibitors in micromolar range and one exhibited sub-micromolar affinities toward Mcl-1 and Bcl-2. The m...
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#1Shelly Gapil Tiamas (UM: University of Malaya)
#2Florian Audet (Institut de Chimie des Substances Naturelles)
Last. Fanny Roussi (Institut de Chimie des Substances Naturelles)H-Index: 8
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