Nagaraj M. Kulkarni
Sahlgrenska University Hospital
Publications 2
#1Emmelie CansbyH-Index: 8
Last.Jan BorénH-Index: 64
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Ectopic lipid storage in the liver is considered the main risk factor for nonalcoholic steatohepatitis (NASH). Understanding the molecular networks controlling hepatocellular lipid deposition is therefore essential for developing new strategies to effectively prevent and treat this complex disease. Here, we describe a new regulator of lipid partitioning in human hepatocytes: mammalian sterile 20–like (MST) 3. We found that MST3 protein coats lipid droplets in mouse and human liver cells. Knockdo...
#1Emmelie Cansby (Sahlgrenska University Hospital)H-Index: 1
#2Esther Nuñez-Durán (Sahlgrenska University Hospital)H-Index: 6
Last.Hanns-Ulrich Marschall (Sahlgrenska University Hospital)H-Index: 46
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Background & Aims Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are emerging as leading causes of liver disease worldwide. Currently, no specific pharmacologic therapy is available for NAFLD/NASH, which has been recognized as one of the major unmet medical needs of the 21st century. Our recent studies in genetic mouse models, human cell lines, and well-characterized patient cohorts have identified serine/threonine protein kinase (STK)25 as a critical regulator ...
#1Silva SüttH-Index: 4
#2Emmelie CansbyH-Index: 8
Last.Brian W. HowellH-Index: 23
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Whole-body energy homeostasis at over-nutrition critically depends on how well adipose tissue remodels in response to excess calories. We recently identified serine/ threonine protein kinase (STK)25 as a critical regulator of ectopic lipid storage in non-adipose tissue and systemic insulin resistance in the context of nutritional stress. Here, we investigated the role of STK25 in regulation of adipose tissue dysfunction in mice challenged with a high-fat diet. We found that overexpression of STK...