Nagaraj M. Kulkarni
Sahlgrenska University Hospital
EndocrinologyWhite adipose tissueNonalcoholic fatty liver diseaseSteatohepatitisFibrosis
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Publications 3
#1Emmelie Cansby (Sahlgrenska University Hospital)H-Index: 1
#2Nagaraj M. Kulkarni (Sahlgrenska University Hospital)H-Index: 1
Last. Margit Mahlapuu (Sahlgrenska University Hospital)H-Index: 20
view all 12 authors...
Ectopic lipid storage in the liver is considered the main risk factor for nonalcoholic steatohepatitis (NASH). Understanding the molecular networks controlling hepatocellular lipid deposition is th...
#1Emmelie Cansby (Sahlgrenska University Hospital)H-Index: 1
#2Esther Nuñez-Durán (Sahlgrenska University Hospital)H-Index: 6
Last. Margit Mahlapuu (Sahlgrenska University Hospital)H-Index: 20
view all 11 authors...
Background & Aims Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are emerging as leading causes of liver disease worldwide. Currently, no specific pharmacologic therapy is available for NAFLD/NASH, which has been recognized as one of the major unmet medical needs of the 21st century. Our recent studies in genetic mouse models, human cell lines, and well-characterized patient cohorts have identified serine/threonine protein kinase (STK)25 as a critical regulator ...
1 CitationsSource
#1Silva SüttH-Index: 4
#2Emmelie CansbyH-Index: 9
Last. Margit MahlapuuH-Index: 20
view all 12 authors...
Whole-body energy homeostasis at over-nutrition critically depends on how well adipose tissue remodels in response to excess calories. We recently identified serine/ threonine protein kinase (STK)25 as a critical regulator of ectopic lipid storage in non-adipose tissue and systemic insulin resistance in the context of nutritional stress. Here, we investigated the role of STK25 in regulation of adipose tissue dysfunction in mice challenged with a high-fat diet. We found that overexpression of STK...
3 CitationsSource