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Costanza L. Vallerga
University of Queensland
Genome-wide association studyHeritabilityGeneticsLocus (genetics)Biology
9Publications
6H-index
89Citations
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Publications 12
Newest
#1Katrina L. Grasby (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 7
#2Neda Jahanshad (SC: University of Southern California)H-Index: 42
Last. Mary Agnes B. McMahon (SC: University of Southern California)H-Index: 1
view all 360 authors...
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with hu...
7 CitationsSource
#1Costanza L. Vallerga (UQ: University of Queensland)H-Index: 6
#2Futao Zhang (UQ: University of Queensland)H-Index: 12
Last. Leanne Wallace (UQ: University of Queensland)H-Index: 12
view all 30 authors...
An improved understanding of etiological mechanisms in Parkinson’s disease (PD) is urgently needed because the number of affected individuals is projected to increase rapidly as populations age. We present results from a blood-based methylome-wide association study of PD involving meta-analysis of 229 K CpG probes in 1,132 cases and 999 controls from two independent cohorts. We identify two previously unreported epigenome-wide significant associations with PD, including cg06690548 on chromosome ...
Source
#1Marta F. Nabais (UQ: University of Queensland)H-Index: 1
#1Marta F. Nabais (UQ: University of Queensland)
Last. Anna Freydenzon (UQ: University of Queensland)
view all 37 authors...
We conducted DNA methylation association analyses using Illumina 450K data from whole blood for an Australian amyotrophic lateral sclerosis (ALS) case–control cohort (782 cases and 613 controls). Analyses used mixed linear models as implemented in the OSCA software. We found a significantly higher proportion of neutrophils in cases compared to controls which replicated in an independent cohort from the Netherlands (1159 cases and 637 controls). The OSCA MOMENT linear mixed model has been shown i...
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#1Mike A. Nalls (NIH: National Institutes of Health)H-Index: 70
#2Cornelis Blauwendraat (NIH: National Institutes of Health)H-Index: 11
Last. Futao ZhangH-Index: 12
view all 232 authors...
Summary Background Genome-wide association studies (GWAS) in Parkinson's disease have increased the scope of biological knowledge about the disease over the past decade. We aimed to use the largest aggregate of GWAS data to identify novel risk loci and gain further insight into the causes of Parkinson's disease. Methods We did a meta-analysis of 17 datasets from Parkinson's disease GWAS available from European ancestry samples to nominate novel loci for disease risk. These datasets incorporated ...
50 CitationsSource
#1Qian Zhang (UQ: University of Queensland)H-Index: 50
#2Costanza L. Vallerga (UQ: University of Queensland)H-Index: 6
Last. Peter M. Visscher (UQ: University of Queensland)H-Index: 109
view all 33 authors...
DNA methylation changes with age. Chronological age predictors built from DNA methylation are termed ‘epigenetic clocks’. The deviation of predicted age from the actual age (‘age acceleration residual’, AAR) has been reported to be associated with death. However, it is currently unclear how a better prediction of chronological age affects such association. In this study, we build multiple predictors based on training DNA methylation samples selected from 13,661 samples (13,402 from blood and 259...
2 CitationsSource
#1Cornelis Blauwendraat (NIH: National Institutes of Health)H-Index: 11
#2Karl HeilbronH-Index: 8
Last. Andrew B. Singleton (NIH: National Institutes of Health)H-Index: 104
view all 42 authors...
Background: Increasing evidence supports an extensive and complex genetic contribution to PD. Previous genome-wide association studies (GWAS) have shed light on the genetic basis of risk for this disease. However, the genetic determinants of PD age at onset are largely unknown. Objectives: To identify the genetic determinants of PD age at onset. Methods: Using genetic data of 28,568 PD cases, we performed a genome-wide association study based on PD age at onset. Results: We estimated that the he...
9 CitationsSource
#1V. Kartik Chundru (UQ: University of Queensland)
#2Riccardo E. MarioniH-Index: 40
Last. Allan F. McRae (UQ: University of Queensland)H-Index: 42
view all 12 authors...
Genetic variants disrupting DNA methylation at CpG dinucleotides (CpG-SNP) provide a set of known causal variants to serve as models for testing fine-mapping methodology. We use 1716 CpG-SNPs to test three fine-mapping approaches (BIMBAM, BSLMM, and the J-test), assessing the impact of imputation errors and the choice of reference panel by using both whole-genome sequence (WGS), and genotype array data on the same individuals (n=1166). The choice of imputation reference panel had a strong effect...
Source
#1Regina H Reynolds (UCL: University College London)H-Index: 3
#2Juan A. Botía (UCL: University College London)H-Index: 19
Last. John V. PearsonH-Index: 48
view all 167 authors...
Parkinson’s disease (PD), with its characteristic loss of nigrostriatal dopaminergic neurons and deposition of α-synuclein in neurons, is often considered a neuronal disorder. However, in recent years substantial evidence has emerged to implicate glial cell types, such as astrocytes and microglia. In this study, we used stratified LD score regression and expression-weighted cell-type enrichment together with several brain-related and cell-type-specific genomic annotations to connect human genomi...
7 CitationsSource
#2Karl HeilbronH-Index: 8
Last. Andrew B. SingletonH-Index: 104
view all 41 authors...
Increasing evidence supports an extensive and complex genetic contribution to Parkinson9s disease (PD). Previous genome-wide association studies (GWAS) have shed light on the genetic basis of risk for this disease. However, the genetic determinants of PD age of onset are largely unknown. Here we performed an age of onset GWAS based on 28,568 PD cases. We estimated that the heritability of PD age of onset due to common genetic variation was ~0.11, lower than the overall heritability of risk for P...
8 CitationsSource
#1Katrina L. Grasby (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 7
#2Neda Jahanshad (SC: University of Southern California)H-Index: 42
Last. Sarah E. Medland (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 77
view all 337 authors...
The cerebral cortex underlies our complex cognitive capabilities, yet we know little about the specific genetic loci influencing human cortical structure. To identify genetic variants impacting cortical structure, we conducted a genome-wide association meta-analysis of brain MRI data from 35,660 individuals with replication in 15,578 individuals. We analysed the surface area and average thickness of the whole cortex and 34 regions with known functional specialisations. We identified 206 nominall...
11 CitationsSource
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