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Saravanan Parameswaran
Gyeongsang National University
6Publications
1H-index
11Citations
Publications 6
Newest
#1Shailima Rampogu (Gyeongsang National University)H-Index: 7
#2Shraddha Parate (Gyeongsang National University)H-Index: 1
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 30
view all 9 authors...
Abstract Breast cancer is one of the major impediments affecting women globally. The ATP-dependant heat shock protein 90 (Hsp90) forms the central component of molecular chaperone machinery that predominantly governs the folding of newly synthesized peptides and their conformational maturation. It regulates the stability and function of numerous client proteins that are frequently upregulated and/or mutated in cancer cells, therefore, making Hsp90 inhibition a promising therapeutic strategy for ...
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#1Amir ZebH-Index: 5
#2Donghwan KimH-Index: 1
Last.Keun Woo LeeH-Index: 30
view all 12 authors...
Mechanistically, neurotoxic insults provoke Ca2+-mediated calpain activation, which cleaves the cytoplasmic region of membrane-embedded p35 and produces its truncated form p25. Upon physical interaction, cyclin-dependent kinase 5 (Cdk5) and p25 forms hyperactivated Cdk5/p25 complex and causes severe neuropathological aberrations including hyperphosphorylated tau-mediated neurofibrillary tangles formation, Alzheimer’s symptoms, and neuronal death. Therefore, the inhibition of Cdk5/p25 complex may...
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#1Raj Kumar (Gyeongsang National University)H-Index: 5
#2Saravanan Parameswaran (Gyeongsang National University)H-Index: 1
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 30
view all 12 authors...
Abstract Prolyl oligopeptidase (POP) is a potential therapeutic target for treatment of several neurological disorders and α-synucleinopathies including Parkinson's disease. Most of the known POP inhibitors failed in the clinical trials due to poor pharmacokinetic properties and blood-brain impermeability. Therefore, a training set of 30 structurally diverse compounds with a wide range of inhibitory activity against POP was used to generate a quantitative pharmacophore model, Hypo 3, to identify...
1 CitationsSource
#1Shailima RampoguH-Index: 7
#2Ayoung BaekH-Index: 7
Last.Keun Woo LeeH-Index: 30
view all 11 authors...
Angiogenesis is defined as the formation of new blood vessels and is a key phenomenon manifested in a host of cancers during which tyrosine kinases play a crucial role. Vascular endothelial growth factor receptor-2 (VEGFR-2) is pivotal in cancer angiogenesis, which warrants the urgency of discovering new anti-angiogenic inhibitors that target the signalling pathways. To obtain this objective, a structure-based pharmacophore model was built from the drug target VEGFR-2 (PDB code: 4AG8), complexed...
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#1Shailima Rampogu (Gyeongsang National University)H-Index: 7
#2Saravanan Parameswaran (Gyeongsang National University)H-Index: 1
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 30
view all 4 authors...
Fenugreek (Trigonella foenum-graecum) is used as a spice throughout the world. It is known for its medicinal properties such as antidiabetic, anticarcinogenic, and immunological activities. The present study shows the properties and the nutritional quality of fenugreek seed extract and focuses on screening of active compounds in drug designing for type 2 diabetes and breast cancer. Quantitative analysis was used to calculate the percentages of protein, carbohydrates moisture, fatty acid, galacto...
1 CitationsSource
#1Shailima Rampogu (Gyeongsang National University)H-Index: 7
#2Minky Son (Gyeongsang National University)H-Index: 8
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 30
view all 8 authors...
Abstract Human epidermal growth factor receptors are implicated in several types of cancers characterized by aberrant signal transduction. This family comprises of EGFR (ErbB1), HER2 (ErbB2, HER2/neu), HER3 (ErbB3), and HER4 (ErbB4). Amongst them, HER2 is associated with breast cancer and is one of the most valuable targets in addressing the breast cancer incidences. For the current investigation, we have performed 3D-QSAR based pharmacophore search for the identification of potential inhibitors...
9 CitationsSource
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