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Nelly Seger
Karolinska Institutet
Telomerase reverse transcriptaseChondrosarcomaMetastasisTumor progressionTelomerase
2Publications
1H-index
3Citations
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Publications 2
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#1Yingbo Lin (KI: Karolinska Institutet)H-Index: 6
#2Nelly Seger (KI: Karolinska Institutet)H-Index: 1
Last. Felix Haglund (KI: Karolinska Institutet)H-Index: 10
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Chondrosarcomas are malignant skeletal tumors with chondroid differentiation. Prognosis is largely dependent on histological grading, which suffer from significant interobserver variability. Telomerase activity and abundant telomerase reverse transcriptase (hTERT) expression has previously been associated with chondrosarcoma grade and metastasis. We therefore analyzed the hTERT promoter in clinicopathologically well-characterized chondrosarcomas (grade 1–3) from 87 patients. Using Sanger sequenc...
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#1Yingbo Lin (KI: Karolinska Institutet)H-Index: 6
#2Nelly Seger (KI: Karolinska Institutet)H-Index: 1
Last. Felix HaglundH-Index: 10
view all 11 authors...
Aims Solitary fibrous tumour (SFT) is an infrequently metastasising mesenchymal tumour defined by the NAB2–STAT6 fusion gene. Activating mutations in the telomerase reverse transcriptase ( hTERT ) gene promoter has been reported to associate with adverse patient outcome in SFTs. Methods We analysed the hTERT gene for promoter mutations and copy number alterations in 43 primary extrameningeal SFTs (9 malignant and 34 benign tumours according to WHO 2013 criteria), six local recurrences and three ...
3 CitationsSource
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