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Joshua S. Mervis
Boston University
DermatologyIntensive care medicineContinuing medical educationDiseaseMedicine
5Publications
2H-index
12Citations
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Publications 7
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#1Joshua S. MervisH-Index: 2
#2Tania J. PhillipsH-Index: 41
Chronic wounds impose a major burden on the individual and healthcare system, accounting for significant morbidity, decreased quality of life, and high costs. Despite the development of various advanced therapeutic modalities, chronic wounds remain extremely difficult to treat. Lasers, well-known for their use in a variety of dermatologic procedures, have been used more recently to treat the functional and aesthetic sequelae of burn injuries and scar-related contractures. Of particular interest ...
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#1Joshua S. Mervis (BU: Boston University)H-Index: 2
#2Jean S. McGee (BU: Boston University)H-Index: 3
Epigenetics is the study of heritable changes in gene expression that do not originate from alternations in the DNA sequence. Epigenetic modifications include DNA methylation, histone modification, and gene silencing via the action of microRNAs. Epigenetic dysregulation has been implicated in many disease processes. In the field of dermatology, epigenetic regulation has been extensively explored as a pathologic mechanism in cutaneous T-cell lymphoma (CTCL), which has led to the successful develo...
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#1Joshua S. Mervis (BU: Boston University)H-Index: 2
#2Tania J. Phillips (BU: Boston University)H-Index: 41
Though preventable in most cases, pressure ulcers continue to pose a major burden to the individual and society, affecting ≤3 million adults annually in the United States alone. Despite increased national attention over the past 20 years, the prevalence of pressure ulcers has largely remained unchanged, while the associated costs of care continue to increase. Dermatologists can play a significant role in pressure ulcer prevention by becoming aware of at-risk populations and implementing suitable...
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#1Joshua S. Mervis (BU: Boston University)H-Index: 2
#2Tania J. Phillips (BU: Boston University)H-Index: 41
Prevention has been a primary goal of pressure ulcer research. Despite such efforts, pressure ulcers remain common in hospitals and in the community. Moreover, pressure ulcers often become chronic wounds that are difficult to treat and that tend to recur after healing. Especially given these challenges, dermatologists should have the knowledge and skills to implement pressure ulcer prevention strategies and to effectively treat pressure ulcers in their patients. This continuing medical education...
2 CitationsSource
#1Joshua S. Mervis (BU: Boston University)H-Index: 2
#2Jean S. McGee (BU: Boston University)H-Index: 3
The epigenetic regulation of gene expression is accomplished primarily through DNA methylation, histone modification, and gene silencing via the action of microRNAs. While previously very difficult to study, the field of epigenetics has been greatly facilitated by recent technological innovations. Alterations in the epigenome and epigenetic machinery are now known to be present in a variety of diseases, most notably cancers. Moreover, evidence has emerged that epigenetic dysregulation plays a ca...
1 CitationsSource
#1Joshua S. Mervis (BU: Boston University)H-Index: 2
#2Brian C. Machler (NYU: New York University)H-Index: 3
Last. Daniel G. Federman (Yale University)H-Index: 28
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#1Ayman Grada (BU: Boston University)H-Index: 8
#2Joshua S. Mervis (BU: Boston University)H-Index: 2
Last. Vincent Falanga (BU: Boston University)H-Index: 61
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Animal models have been developed to study the complex cellular and biochemical processes of wound repair and to evaluate the efficacy and safety of potential therapeutic agents. Several factors can influence wound healing. These include aging, infection, medications, nutrition, obesity, diabetes, venous insufficiency, and peripheral arterial disease. Lack of optimal preclinical models that are capable of properly recapitulating human wounds remains a significant translational challenge. Animal ...
9 CitationsSource
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