Joshua S. Mervis
Boston University
Publications 5
#1Joshua S. Mervis (BU: Boston University)H-Index: 1
#2Tania J. Phillips (BU: Boston University)H-Index: 40
Abstract Though preventable in the vast majority of cases, pressure ulcers continue to pose a major burden to the individual and society, affecting up to 3 million adults annually in the United States alone. Despite increased national attention over the past 20 years, the prevalence of pressure ulcers has largely remained unchanged, while associated costs of care continue to increase. Dermatologists can play a significant role in pressure ulcer prevention by becoming aware of at-risk populations...
#1Joshua S. Mervis (BU: Boston University)H-Index: 1
#2Tania J. Phillips (BU: Boston University)H-Index: 40
Abstract Prevention has been a primary goal of pressure ulcer research. Despite such efforts, pressure ulcers remain common in hospitals and the community. Moreover, pressure ulcers often become chronic wounds that are difficult to treat and tend to recur after healing. Especially given these challenges, dermatologists should have the knowledge and skills to implement pressure ulcer prevention strategies and to effectively treat pressure ulcers in their patients. This continuing medical educatio...
#1Joshua S. Mervis (BU: Boston University)H-Index: 1
#2Jean S. McGee (BU: Boston University)H-Index: 3
AbstractThe epigenetic regulation of gene expression is accomplished primarily through DNA methylation, histone modification, and gene silencing via the action of microRNAs. While previously very difficult to study, the field of epigenetics has been greatly facilitated by recent technological innovations. Alterations in the epigenome and epigenetic machinery are now known to be present in a variety of diseases, most notably cancers. Moreover, evidence has emerged that epigenetic dysregulation pl...
#1Joshua S. Mervis (BU: Boston University)H-Index: 1
#2Brian C. Machler (NYU: New York University)H-Index: 2
Last.Daniel G. Federman (Yale University)H-Index: 27
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#1Ayman Grada (BU: Boston University)H-Index: 5
#2Joshua S. Mervis (BU: Boston University)H-Index: 1
Last.Vincent Falanga (BU: Boston University)H-Index: 3
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Animal models have been developed to study the complex cellular and biochemical processes of wound repair and to evaluate the efficacy and safety of potential therapeutic agents. Several factors can influence wound healing. These include aging, infection, medications, nutrition, obesity, diabetes, venous insufficiency, and peripheral arterial disease. Lack of optimal preclinical models that are capable of properly recapitulating human wounds remains a significant translational challenge. Animal ...