Sarah H. Williams
University of Oxford
Publications 4
#1Laurent J. Livermore (University of Oxford)H-Index: 4
#2Sarah H. Williams (University of Oxford)H-Index: 2
Last.Puneet Plaha (University of Oxford)H-Index: 11
view all 7 authors...
#1Sarah H. Williams (University of Oxford)H-Index: 2
#2Li Chen (University of Oxford)H-Index: 6
Last.Philip W.J. Burnet (University of Oxford)H-Index: 31
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Compelling data suggest that perturbations in microbial colonization of the gut in early-life, influences neurodevelopment and adult brain function. If this is the case, then ensuring the growth of beneficial bacteria at an early age will lead to optimal brain development and maturation. We have tested whether feeding neonatal rats daily (from post-natal days 3-21) with a galacto-oligosaccharide prebiotic (Bimuno®, BGOS) or a control solution, alters the levels of hippocampal N-Methyl-D-Aspartat...
28 CitationsSource
#1Marzena Anna Lewandowska (NU: Northwestern University)H-Index: 13
#2Fabricio F. Costa (NU: Northwestern University)H-Index: 24
Last.Ann HarrisH-Index: 24
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The cystic fibrosis transmembrane conductance regulator (CFTR) gene is driven by a promoter that cannot alone account for the temporal and tissue-specific regulation of the gene. This has led to the search for additional regulatory elements that cooperate with the basal promoter to achieve coordinated expression. We previously identified two alternative upstream exons of the gene that were mutually exclusive of the first exon, and one of which showed temporal regulation in the human and sheep lu...
15 CitationsSource
Transfer of P1-derived artificial chromosome (PAC) deoxyribonucleic acid (DNA) into keratinocytes is an extremely important technique that enables functional studies of keratinocyte-specific genes to be performed and genomic gene therapy for inherited and acquired diseases to be attempted. Ex vivo gene therapy approaches are possible using well-established conditions for keratinocyte culture and grafting, whilst the skin is the most accessible organ for administering in vivo therapy. PAC vectors...