Garth Rees Cosgrove
Brigham and Women's Hospital
Publications 3
Published on Sep 18, 2019in bioRxiv
Angelique C. Paulk15
Estimated H-index: 15
(Harvard University),
Jingyun Yang23
Estimated H-index: 23
(Harvard University)
+ 26 AuthorsNick Rogers2
Estimated H-index: 2
(UCSD: University of California, San Diego)
Efforts to deepen our understanding of the nervous system depends on high resolution sampling of neuronal activity. We leveraged clinically necessary intracranial monitoring performed during surgical resections to record from the cortical surface (N=30) using high spatial resolution, low impedance PEDOT:PSS microelectrodes. We identified three classes of activity. The first included relatively fast repeated waveforms with kinetics similar to, but not perfectly matching, extracellular single unit...
Published on Jun 11, 2018in bioRxiv
Marta Olah13
Estimated H-index: 13
(CUMC: Columbia University Medical Center),
Vilas Menon1
Estimated H-index: 1
(CUMC: Columbia University Medical Center)
+ 20 AuthorsMatthew P. Frosch74
Estimated H-index: 74
(Harvard University)
Recent studies of bulk microglia have provided insights into the role of this immune cell type in central nervous system development, homeostasis and dysfunction. Nonetheless, our understanding of the diversity of human microglial cell states remains limited. Microglia are highly plastic and have multiple different roles, making the extent of phenotypic heterogeneity a central question, especially in light of the development of therapies targeting this cell type. Here, we investigated the popula...
Published on Mar 1, 2018in Advanced Functional Materials15.62
Mehran Ganji3
Estimated H-index: 3
(UCSD: University of California, San Diego),
Erik Kaestner5
Estimated H-index: 5
(UCSD: University of California, San Diego)
+ 15 AuthorsGarth Rees Cosgrove2
Estimated H-index: 2
(Brigham and Women's Hospital)
Recording neural activity during neurosurgical interventions is an invaluable tool for both improving patient outcomes and advancing our understanding of neural mechanisms and organization. However, increasing clinical electrodes' signal-to-noise and spatial specificity requires overcoming substantial physical barriers due to the compromised metal electrochemical interface properties. The electrochemical properties of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) based inte...