G. R. Cosgrove
Brigham and Women's Hospital
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Publications 5
#1Rina Zelmann (Harvard University)H-Index: 27
#1R. Zelmann (Harvard University)
Last. D. S. Weisholtz (Brigham and Women's Hospital)
view all 14 authors...
Targeted interrogation of brain networks through invasive brain stimulation has become an increasingly important research tool as well as a therapeutic modality. The majority of work with this emerging capability has been focused on open-loop approaches. Closed-loop techniques, however, could improve neuromodulatory therapies and research investigations by optimizing stimulation approaches using neurally informed, personalized targets. Specifically, closed-loop direct electrical stimulation test...
2 CitationsSource
#1Angelique C. Paulk (Harvard University)H-Index: 17
#2Ali Yousefi (WPI: Worcester Polytechnic Institute)H-Index: 6
Last. Sydney S. Cash (Harvard University)H-Index: 51
view all 24 authors...
The ability to regulate emotions in the service of meeting ongoing goals and task demands is a key aspect of adaptive human behavior in our volatile social world. Consequently, difficulties in processing and responding to emotional stimuli underlie many psychiatric diseases ranging from depression to anxiety, the common thread being effects on behavior. Behavior, which is made up of shifting, difficult to measure hidden states such as attention and emotion reactivity, is a product of integrating...
1 CitationsSource
#1Angelique C. Paulk (Harvard University)H-Index: 17
#2Jae-Hyun Yang (Harvard University)H-Index: 2
Last. Sydney S. Cash (Harvard University)H-Index: 51
view all 29 authors...
Efforts to deepen our understanding of the nervous system depends on high resolution sampling of neuronal activity. We leveraged clinically necessary intracranial monitoring performed during surgical resections to record from the cortical surface (N=30) using high spatial resolution, low impedance PEDOT:PSS microelectrodes. We identified three classes of activity. The first included relatively fast repeated waveforms with kinetics similar to, but not perfectly matching, extracellular single unit...
#1Marta Olah (CUMC: Columbia University Medical Center)H-Index: 15
#2Vilas Menon (CUMC: Columbia University Medical Center)H-Index: 1
Last. P. L. De Jager (CUMC: Columbia University Medical Center)H-Index: 23
view all 23 authors...
Recent studies of bulk microglia have provided insights into the role of this immune cell type in central nervous system development, homeostasis and dysfunction. Nonetheless, our understanding of the diversity of human microglial cell states remains limited. Microglia are highly plastic and have multiple different roles, making the extent of phenotypic heterogeneity a central question, especially in light of the development of therapies targeting this cell type. Here, we investigated the popula...
11 CitationsSource
#1Mehran Ganji (UCSD: University of California, San Diego)H-Index: 5
#2Erik Kaestner (UCSD: University of California, San Diego)H-Index: 6
Last. Shadi A. Dayeh (UCSD: University of California, San Diego)H-Index: 32
view all 18 authors...
Recording neural activity during neurosurgical interventions is an invaluable tool for both improving patient outcomes and advancing our understanding of neural mechanisms and organization. However, increasing clinical electrodes' signal-to-noise and spatial specificity requires overcoming substantial physical barriers due to the compromised metal electrochemical interface properties. The electrochemical properties of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) based inte...
25 CitationsSource