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Quentin M. Anstee
Newcastle University
228Publications
39H-index
5,389Citations
Publications 228
Newest
Published on Dec 1, 2018in Clinical Gastroenterology and Hepatology 7.96
Yvonne Huber4
Estimated H-index: 4
(University of Mainz),
Marie Boyle5
Estimated H-index: 5
(Newcastle University)
+ 8 AuthorsQuentin M. Anstee39
Estimated H-index: 39
(Newcastle University)
Background & Aims Chronic liver disease has negative effects on health-related quality of life (HRQL). We analyzed data from the European non-alcoholic fatty liver disease (NAFLD) registry to assess the effects of NAFLD on HRQL. Methods We collected data from 304 patients (mean age, 52.3 ± 12.9 years) with histologically defined NAFLD enrolled prospectively into the European NAFLD Registry in Germany, the United Kingdom, and Spain. The chronic liver disease questionnaire (CLDQ) was completed wit...
Published on Sep 1, 2019in Contemporary Clinical Trials 2.28
Vlad Ratziu67
Estimated H-index: 67
(University of Paris),
Arun J. Sanyal97
Estimated H-index: 97
(VCU: Virginia Commonwealth University)
+ 9 AuthorsReshma Shringarpure3
Estimated H-index: 3
(Intercept Pharmaceuticals)
Abstract Background Nonalcoholic steatohepatitis (NASH) is a chronic, progressive, and severe form of nonalcoholic fatty liver disease. In FLINT, obeticholic acid (OCA) treatment improved multiple histological NASH features. The design and endpoints of REGENERATE, an ongoing phase 3 study, further evaluate OCA treatment in patients with fibrosis due to NASH. Aims The Month 18 interim analysis assesses the effect of OCA on liver histology, defined as improvement of fibrosis by ≥1 stage with no wo...
Published on Jul 4, 2019in Hepatology 14.97
Quentin M. Anstee39
Estimated H-index: 39
(Newcastle University),
Eric Lawitz (University of Texas at Austin)+ 22 AuthorsLing Han3
Estimated H-index: 3
Published on Apr 26, 2019in Nature Reviews Gastroenterology & Hepatology 23.57
Quentin M. Anstee39
Estimated H-index: 39
(Newcastle University),
Helen L. Reeves26
Estimated H-index: 26
(Newcastle upon Tyne Hospitals NHS Foundation Trust)
+ 2 AuthorsMathias Heikenwalder60
Estimated H-index: 60
(DKFZ: German Cancer Research Center)
Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity, nonalcoholic fatty liver disease (NAFLD), is estimated to affect up to one-third of the adult population in many developed and developing countries. This spectrum of liver disease ranges from simple steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Owing to the high prevalence of NAFLD, especially in industrialized countr...
Published on Jul 1, 2019in Journal of Hepatology 18.95
Mary Eugenia Rinella24
Estimated H-index: 24
(NU: Northwestern University),
F. Tacke1
Estimated H-index: 1
(Charité)
+ 1 AuthorsQuentin M. Anstee39
Estimated H-index: 39
(Newcastle University)
Summary Non-alcoholic fatty liver disease (NAFLD) is a global public health concern. Its natural history, the development of non-alcoholic steatohepatitis (NASH) and fibrosis, is highly variable, prone to endogenous ( e.g. , genetics, microbiota) and exogenous ( e.g. , nutrition, alcohol, physical activity) disease modifiers, and can fluctuate over time. The complexity of its pathophysiology is reflected by the multitude of pharmacological targets in development. NASH clinical trials have provid...
Published on Jul 1, 2019
Marie Boyle5
Estimated H-index: 5
(Newcastle University),
Dina Tiniakos29
Estimated H-index: 29
(Newcastle University)
+ 13 AuthorsStuart McPherson18
Estimated H-index: 18
(Newcastle University)
Abstract Background There is an unmet need for non-invasive biomarkers in NAFLD for the diagnosis of advanced disease and identification of patients suitable for clinical trials. The PRO-C3 collagen neo-epitope is a putative direct marker of fibrogenesis. We assessed performance of PRO-C3 in a large, well characterised international NAFLD cohort and report the development and validation of two novel panels for the diagnosis of advanced fibrosis (F ≥ 3) in NAFLD, including a simplified clinical s...
Published on Jun 1, 2019in Journal of Hepatology 18.95
David Houghton8
Estimated H-index: 8
(Newcastle University),
Paweł Zalewski7
Estimated H-index: 7
(UMK: Nicolaus Copernicus University in Toruń)
+ 15 AuthorsDina Tiniakos29
Estimated H-index: 29
(Newcastle University)
Background & Aims Cardiovascular disease is the principle cause of death in patients with elevated liver fat unrelated to alcohol consumption, more so than liver-related morbidity and mortality. The aim of this study was to evaluate the relationship between liver fat and cardiac and autonomic function, as well as to assess how impairment in cardiac and autonomic function is influenced by metabolic risk factors. Methods Cardiovascular and autonomic function were assessed in 96 sedentary individua...
Published on Jun 1, 2019in Alimentary Pharmacology & Therapeutics 7.73
Federico Ravaioli5
Estimated H-index: 5
(UNIBO: University of Bologna),
Quentin M. Anstee39
Estimated H-index: 39
(Newcastle University)
Published on Jun 1, 2019in Clinical Gastroenterology and Hepatology 7.96
Laura Haigh (Newcastle University), Susan Bremner (Newcastle upon Tyne Hospitals NHS Foundation Trust)+ 6 AuthorsStuart McPherson18
Estimated H-index: 18
(Newcastle University)
Background & Aims Dietary interventions for weight loss are effective therapies for nonalcoholic fatty liver disease (NAFLD). The Mediterranean diet might benefit these patients, but it is not followed consistently in Northern European countries. We examined factors that determine Mediterranean diet adoption and maintenance in a northern European population. Methods We used a mixed-methods approach to investigate the effects of a 12-week Mediterranean diet intervention and perceived barriers and...
Published on May 23, 2019in Translational behavioral medicine 2.24
Kate Hallsworth14
Estimated H-index: 14
(Newcastle University),
Stephan U Dombrowski19
Estimated H-index: 19
(UNB: University of New Brunswick)
+ 2 AuthorsLeah Avery7
Estimated H-index: 7
(Teesside University)
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