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Benjamin R. Herbert
Royal North Shore Hospital
Macrophage migration inhibitory factorWhole bloodRed blood cellInflammationHaemolysis
4Publications
2H-index
16Citations
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Publications 3
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#1Elisabeth Karsten (USYD: University of Sydney)H-Index: 1
#2Edmond J. BreenH-Index: 13
Last. Benjamin R. Herbert (RNSH: Royal North Shore Hospital)H-Index: 2
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It is now accepted that red blood cells (RBCs) from healthy individuals regulate T-cell activity through modulating cytokine interactions, and that stored RBCs or RBCs from inflammatory cohorts are dysfunctional. Our study aimed to investigate how changes in RBCs that have been intentionally modified can affect T-cell activity as a mechanistic test of this modification. Exposure to a cancer cell line in culture was used to alter the cytokine profile of intact RBCs and the effect of these modifie...
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#1Elisabeth Karsten (RNSH: Royal North Shore Hospital)H-Index: 1
#2Benjamin R. Herbert (RNSH: Royal North Shore Hospital)H-Index: 2
Abstract For many years red blood cells have been described as inert bystanders rather than participants in intercellular signalling, immune function, or inflammatory processes. However, studies are now reporting that red blood cells from healthy individuals regulate immune cell activity and maturation, and red blood cells from disease cohorts are dysfunctional. These cells have now been shown to bind more than 50 cytokines and have been described as a sink for these molecules, and the loss of t...
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#1Elisabeth Karsten (RNSH: Royal North Shore Hospital)H-Index: 1
#2Cameron J. HillH-Index: 7
Last. Benjamin R. Herbert (RNSH: Royal North Shore Hospital)H-Index: 2
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Abstract Red blood cells are widely accepted to be inert carriers of oxygen and haemoglobin, but there is growing evidence that they play a much more critical role in immune function. Macrophage migration inhibitory factor (MIF) is a key cytokine in disease with additional oxido-reductase activity, which aids in managing oxidative stress. Although two studies have reported the presence of MIF in red blood cells, no study has quantified the levels of this protein. In this study, freshly isolated ...
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