Katherine J. Kearney
University of Leeds
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Publications 4
Last. Ramzi AjjanH-Index: 33
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Bleeding complications secondary to surgery, trauma, or coagulation disorders are important causes of morbidity and mortality. Although fibrin sealants are considered to minimize blood loss, this is not widely adopted because of its high cost and/or risk for infection. We present a novel methodology employing nonantibody fibrinogen-binding proteins, termed Affimers, to stabilize fibrin networks with the potential to control excessive bleeding. Two fibrinogen-specific Affimer proteins, F5 and G2,...
#1Fraser L. MacraeH-Index: 7
#2Cédric DuvalH-Index: 11
Last. Robert A. S. Ariëns (University of Leeds)H-Index: 41
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Hemostasis requires conversion of fibrinogen to fibrin fibers that generate a characteristic network, interact with blood cells, and initiate tissue repair. The fibrin network is porous and highly permeable, but the spatial arrangement of the external clot face is unknown. Here we show that fibrin transitioned to the blood-air interface through Langmuir film formation, producing a protective film confining clots in human and mouse models. We demonstrated that only fibrin is required for formatio...
14 CitationsSource
#1Katherine J. Kearney (University of Leeds)H-Index: 2
#2Darren C. Tomlinson (University of Leeds)H-Index: 23
Last. Ramzi Ajjan (University of Leeds)H-Index: 33
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An enhanced thrombotic environment and premature atherosclerosis are key factors for the increased cardiovascular risk in diabetes. The occlusive vascular thrombus, formed secondary to interactions between platelets and coagulation proteins, is composed of a skeleton of fibrin fibres with cellular elements embedded in this network. Diabetes is characterised by quantitative and qualitative changes in coagulation proteins, which collectively increase resistance to fibrinolysis, consequently augmen...
12 CitationsSource
#1Rhodri KingH-Index: 7
#2Ramzi AjjanH-Index: 33
Last. Cwg FishwickH-Index: 1
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