Scott J. Weissman
Seattle Children's Research Institute
Publications 11
#1Arianna Miles-Jay (UW: University of Washington)H-Index: 3
#2Scott J. Weissman (Seattle Children's Research Institute)H-Index: 5
Last.Danielle M. Zerr (Seattle Children's Research Institute)H-Index: 10
view all 7 authors...
Background: E. coli ST131- H30 is a globally important pathogen implicated in rising rates of multidrug resistance among E. coli causing extraintestinal infections. Previous studies have focused on adults, leaving the epidemiology of H30 among children undefined. Methods: We used clinical data and isolates from a case-control study of extended-spectrum cephalosporin-resistant E. coli conducted at four US childrens hospitals to estimate the burden and identify host correlates of infection with H3...
#1Genevieve L. Buser (Oregon Health Authority)H-Index: 8
#2P. Maureen Cassidy (Oregon Health Authority)H-Index: 7
Last.Zintars G. Beldavs (Oregon Health Authority)H-Index: 17
view all 13 authors...
Abstract The first Oregon case of New Delhi metallo-β-lactamase-1 (NDM-1)-producing Escherichia coli was reported during November 2013. Epidemiologic investigation revealed only local outpatient medical care and no travel outside Oregon for both the patient and his household contact. Environmental sampling discovered a matching isolate from the patient’s household vacuum cleaner, suggesting environmental persistence.
#1Joel E. Mortensen (Cincinnati Children's Hospital Medical Center)H-Index: 22
#2Barbara DeBurger (Cincinnati Children's Hospital Medical Center)H-Index: 2
Last.Scott J. Weissman (Seattle Children's Research Institute)H-Index: 5
view all 6 authors...
Although carbapenem-resistant Enterobacteriaceae (CRE) have been recognised worldwide, there are important gaps in regional prevalence data. This study sought to determine the occurrence and type of CRE in the Cincinnati tri-state region. Clinical microbiology laboratories in the region screened patient stool and rectal swab samples using chromogenic screening agar. Isolates of Enterobacteriaceae resistant to carbapenems were characterised using molecular methods. Area institutions screened 1939...
1 CitationsSource
#1Scott J. Weissman (Seattle Children's Research Institute)H-Index: 5
#2Nellie I. Hansen (RTP: Research Triangle Park)H-Index: 30
Last.Barbara J. Stoll (Emory University)H-Index: 86
view all 5 authors...
Escherichia coli associated with early-onset sepsis (EOS) have historically been antibiotic-susceptible and K1-encapsulated. In the era of emerging antibiotic resistance, however, the clonal makeup of E coli associated with EOS has not been well characterized.Escherichia coli isolates were collected from 28 cases of EOS and early-onset meningitis (EOM) from April 2008 through December 2009, during a parent study conducted at National Institute of Child Health and Human Development Neonatal Resea...
14 CitationsSource
Abstract Multi-locus sequence typing (MLST) is a useful system for phylogenetic and epidemiological studies of multidrug-resistant E scherichia coli . Most studies utilize a seven-locus MLST, but an alternate two-locus typing method ( fumC and fimH ; CH typing) has been proposed that may offer a similar degree of discrimination at lower cost. Herein, we compare CH typing to the standard seven-locus method for typing commensal E. coli isolates from dairy cattle. In addition, we evaluated alternat...
1 CitationsSource
#1Kristen A. Wendorf (CDC: Centers for Disease Control and Prevention)H-Index: 3
#2Meagan Kay (Public Health – Seattle & King County)H-Index: 7
Last.Jeffrey S. Duchin (Public Health – Seattle & King County)H-Index: 25
view all 12 authors...
BACKGROUND We identified an outbreak of AmpC–producing Escherichia coli infections resistant to third-generation cephalosporins and carbapenems (CR) among 7 patients who had undergone endoscopic retrograde cholangiopancreatography at hospital A during November 2012–August 2013. Gene sequencing revealed a shared novel mutation in a bla CMY gene and a distinctive fumC/ fimH typing profile. OBJECTIVE To determine the extent and epidemiologic characteristics of the outbreak, identify potential sourc...
94 CitationsSource
#1Kirthi K. Kutumbaka (Forest Park)H-Index: 3
#2Sukkyun Han (Forest Park)H-Index: 2
Last.Mansour Samadpour (Forest Park)H-Index: 30
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ABSTRACT A multidrug-resistant NDM-1 carbapenamase-producing Escherichia coli sequence type 131 (ST131) organism was obtained from vacuum cleaner dust collected from the home of a case patient. Here, we report the assembly and annotation of its genome.
9 CitationsSource
#1Malaika L. Little (Seattle Children's Research Institute)H-Index: 1
#2Xuan Qin (Seattle Children's Research Institute)H-Index: 1
Last.Scott J. Weissman (Seattle Children's Research Institute)H-Index: 5
view all 4 authors...
Klebsiella pneumoniae causes a range of clinical disease in paediatric patients and is of increasing concern due to growing antibiotic resistance, yet little is known about the relative distribution of commensal and pathogens throughout the population structure of K. pneumoniae. We conducted a prospective, observational study of 92 isolates from Seattle Children’s Hospital, including 49 disease isolates from blood and urine (13 and 36 isolates, respectively) and 43 colonization isolates from sto...
7 CitationsSource
#1Sujay Chattopadhyay (UW: University of Washington)H-Index: 6
#2Fred Taub (UW: University of Washington)H-Index: 6
Last.Evgeni V. Sokurenko (UW: University of Washington)H-Index: 35
view all 5 authors...
Analysis of genetic differences (gene presence/absence and nucleotide polymorphisms) among strains of a bacterial species is crucial to understanding molecular mechanisms of bacterial pathogenesis and selecting targets for novel antibacterial therapeutics. However, lack of genome-wide association studies on large and epidemiologically well-defined strain collections from the same species makes it difficult to identify the genes under positive selection and define adaptive polymorphisms in those ...
7 CitationsSource
#1Dagmara I. Kisiela (UW: University of Washington)H-Index: 11
#2Sujay Chattopadhyay (UW: University of Washington)H-Index: 20
Last.Evgeni V. Sokurenko (UW: University of Washington)H-Index: 35
view all 8 authors...
ABSTRACT Salmonella and Escherichia coli mannose-binding type 1 fimbriae exhibit highly similar receptor specificities, morphologies, and mechanisms of assembly but are nonorthologous in nature, i.e., not closely related evolutionarily. Their operons differ in chromosomal location, gene arrangement, and regulatory components. In the current study, we performed a comparative genetic and structural analysis of the major structural subunit, FimA, from Salmonella and E. coli and found that FimA pili...
5 CitationsSource