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Gerburg K. Schwaerzer
University of California, San Diego
3Publications
2H-index
18Citations
Publications 3
Newest
#1Gerburg K. Schwaerzer (UCSD: University of California, San Diego)H-Index: 2
#2Hema Kalyanaraman (UCSD: University of California, San Diego)H-Index: 5
Last.Hemal H. Patel (UCSD: University of California, San Diego)H-Index: 41
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People heterozygous for an activating mutation in protein kinase G1 (PRKG1, p.Arg177Gln) develop thoracic aortic aneurysms and dissections (TAAD) as young adults. Here we report that mice heterozygous for the mutation have a three-fold increase in basal protein kinase G (PKG) activity, and develop age-dependent aortic dilation. Prkg1R177Q/+ aortas show increased smooth muscle cell apoptosis, elastin fiber breaks, and oxidative stress compared to aortas from wild type littermates. Transverse aort...
#1Hema Kalyanaraman (UCSD: University of California, San Diego)H-Index: 5
#2Gerburg K. Schwaerzer (UCSD: University of California, San Diego)H-Index: 2
Last.Renate B. Pilz (UCSD: University of California, San Diego)H-Index: 32
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Bone loss and fractures are underrecognized complications of type 1 diabetes and are primarily due to impaired bone formation by osteoblasts. The mechanisms leading to osteoblast dysfunction in diabetes are incompletely understood, but insulin deficiency, poor glycemic control, and hyperglycemia-induced oxidative stress likely contribute. Here we show that insulin promotes osteoblast proliferation and survival via the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG)...
#1Jisha Joshua (UCSD: University of California, San Diego)H-Index: 5
#2Gerburg K. Schwaerzer (UCSD: University of California, San Diego)H-Index: 2
Last.Renate B. Pilz (UCSD: University of California, San Diego)H-Index: 32
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Osteoporosis is a major health problem leading to fractures that cause substantial morbidity and mortality. Current osteoporosis therapies have significant drawbacks, creating a need for novel bone-anabolic agents. We previously showed that the nitric oxide/cyclic GMP (cGMP)/protein kinase G pathway mediates some of the anabolic effects of estrogens and mechanical stimulation in osteoblasts and osteocytes, leading us to hypothesize that cGMP-elevating agents may have bone-protective effects. We ...
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