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L. Cassard
French Institute of Health and Medical Research
7Publications
4H-index
178Citations
Publications 7
Newest
#1Céline BoutrosH-Index: 5
#2Nathalie ChaputH-Index: 43
Last.Eric Deutsch (French Institute of Health and Medical Research)H-Index: 43
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#1Roberto FerraraH-Index: 11
#2M. NaigeonH-Index: 1
Last.Nathalie ChaputH-Index: 43
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#1Melinda Charrier (French Institute of Health and Medical Research)H-Index: 3
#2Laura Mezquita (French Institute of Health and Medical Research)H-Index: 8
Last.Nathalie Chaput (French Institute of Health and Medical Research)H-Index: 43
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Abstract Introduction Innate immunity represents the first step of activation of the immune system and dictates the quality of adaptive immune responses. Studies have reported links between systemic inflammatory or innate immune markers and prognosis in patients with lung cancer. To our knowledge, the prospective and concomitant study of these systemic markers has never been performed. Methods Advanced treatment-naive non–small cell lung cancer (NSCLC) patients eligible for first-line platinum-b...
1 CitationsSource
#1Fabien Pitoiset (University of Paris)H-Index: 8
#2L. Cassard (French Institute of Health and Medical Research)H-Index: 4
Last.Michelle Rosenzwajg (University of Paris)H-Index: 29
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5 CitationsSource
#1Clélia Coutzac (French Institute of Health and Medical Research)H-Index: 7
#2Julien Adam (French Institute of Health and Medical Research)H-Index: 21
Last.Nathalie Chaput (French Institute of Health and Medical Research)H-Index: 43
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27 CitationsSource
#1Nathalie Chaput (French Institute of Health and Medical Research)H-Index: 43
#2Patricia Lepage (Agro ParisTech)H-Index: 37
Last.Franck CarbonnelH-Index: 41
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Ipilimumab, an immune checkpoint inhibitor targeting CTLA-4, prolongs survival in a subset of patients with metastatic melanoma but can induce immune-related adverse events, including enterocolitis. We hypothesized that baseline gut microbiota could predict ipilimumab anti-tumor response and/or intestinal toxicity. Twenty-six patients with metastatic melanoma treated with ipilimumab were prospectively enrolled. Fecal microbiota composition was assessed using 16S rRNA gene sequencing at baseline ...
136 CitationsSource
#1Mélanie DesboisH-Index: 7
#2Pauline Le Vu (French Institute of Health and Medical Research)H-Index: 1
Last.Nathalie ChaputH-Index: 43
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Tumors with the help of the surrounding environment facilitate the immune suppression in patients, and immunotherapy can counteract this inhibition. Among immunotherapeutic strategies, the immunostimulatory cytokine IL-15 could represent a serious candidate for the reactivation of antitumor immunity. However, exogenous IL-15 may have a limited impact on patients with cancer due to its dependency on IL-15Rα frequently downregulated in cancer patients. In this work, we studied the antitumor activi...
9 CitationsSource
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